Detail Information

Basic Information:


  VIRBase ID:  

VHID00396940

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:           JAG1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART9-5p JAG1
miRBase
Accession/Entrez ID		 MIMAT0004816 182
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - AGS//AGS1//AHD//AWS//CD339//DCHE//HJ1//JAGL1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR JAG1
chr20:10646887(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase JAG1
chr20:10618350-10618351(-) m6A 3'UTR       24981863//27773535
chr20:10618424-10618425(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr20:10618448-10618449(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr20:10618469-10618470(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr20:10618493-10618494(-) m6A 3'UTR//exon       25456834//24981863
chr20:10618890-10618891(-) m6A 3'UTR//intron       26404942
chr20:10619566-10619567(-) m6A 3'UTR//intron       26404942
chr20:10619628-10619629(-) m6A 3'UTR//intron       24981863//26404942
chr20:10619701-10619702(-) m6A 3'UTR//intron       24981863//26404942
chr20:10620089-10620090(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr20:10620141-10620142(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr20:10620167-10620168(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr20:10620191-10620192(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr20:10620200-10620201(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr20:10620205-10620206(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr20:10620213-10620214(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr20:10620218-10620219(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr20:10620226-10620227(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr20:10620263-10620264(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr20:10620317-10620318(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr20:10620351-10620352(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr20:10620374-10620375(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr20:10620380-10620381(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr20:10620418-10620419(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr20:10620431-10620432(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr20:10620443-10620444(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr20:10620476-10620477(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr20:10621433-10621434(-) m6A CDS//exon       24284625
chr20:10621782-10621783(-) m6A CDS//exon       27773535
chr20:10622144-10622145(-) m6A CDS//exon       27773535
chr20:10622187-10622188(-) m6A CDS//exon       27773535
chr20:10625620-10625621(-) m6A CDS//exon       26404942//27773535
chr20:10625805-10625806(-) m6A CDS//exon       26404942//27773535
chr20:10628633-10628634(-) m6A 3'UTR//CDS//exon       26404942
chr20:10628651-10628652(-) m6A 3'UTR//CDS//exon       26404942
chr20:10628666-10628667(-) m6A 3'UTR//CDS//exon       26404942
chr20:10639154-10639155(-) m6A CDS//exon       26404942
chr20:10639185-10639186(-) m6A CDS//exon       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate JAG1
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART9-5p
Interactor2: JAG1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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