Detail Information

Basic Information:


  VIRBase ID:  

VHID00396929

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:           ADAR:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART9-5p ADAR
miRBase
Accession/Entrez ID		 MIMAT0004816 103
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - ADAR1//AGS6//DRADA//DSH//DSRAD//G1P1//IFI-4//IFI4//K88DSRBP//P136

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ADAR
chr1:154565377(-) A-I      intronic
chr1:154585889(-) A-I      intronic
chr1:154586214(-) A-I      intronic
chr1:154585893(-) A-I      intronic
chr1:154586304(-) A-I      intronic
chr1:154598264(-) A-I      intronic
chr1:154598663(-) A-I      intronic
chr1:154585032(-) A-I      intronic
chr1:154584936(-) A-I      intronic
chr1:154598659(-) A-I      intronic
chr1:154585420(-) A-I      intronic
chr1:154585426(-) A-I      intronic
chr1:154598785(-) A-I      intronic
chr1:154584975(-) A-I      intronic
chr1:154586215(-) A-I      intronic
chr1:154586298(-) A-I      intronic
chr1:154585436(-) A-I      intronic
chr1:154584974(-) A-I      intronic
chr1:154584973(-) A-I      intronic
chr1:154585004(-) A-I      intronic
chr1:154585850(-) A-I      intronic
chr1:154598786(-) A-I      intronic
chr1:154565449(-) A-I      intronic
chr1:154586280(-) A-I      intronic
chr1:154598398(-) A-I      intronic
chr1:154565463(-) A-I      intronic
chr1:154565446(-) A-I      intronic
chr1:154586297(-) A-I      intronic
chr1:154584942(-) A-I      intronic
chr1:154578706(-) A-I      5'UTR
chr1:154598541(-) A-I      intronic
chr1:154598538(-) A-I      intronic
chr1:154586049(-) A-I      intronic
chr1:154585921(-) A-I      intronic
chr1:154588006(-) A-I      intronic
chr1:154586193(-) A-I      intronic
chr1:154584978(-) A-I      intronic
chr1:154566590(-) A-I      intronic
chr1:154598428(-) A-I      intronic
chr1:154586050(-) A-I      intronic
chr1:154598105(-) A-I      intronic
chr1:154585943(-) A-I      intronic
chr1:154598880(-) A-I      intronic
chr1:154598466(-) A-I      intronic
chr1:154598078(-) A-I      intronic
chr1:154598309(-) A-I      intronic
chr1:154563373(-) A-I      intronic
chr1:154586007(-) A-I      intronic
chr1:154563368(-) A-I      intronic
chr1:154598317(-) A-I      intronic
chr1:154585857(-) A-I      intronic
chr1:154585043(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ADAR
chr1:154563368(-) A-G intron -    22484847
chr1:154578706(-) A-G intron -    22484847
chr1:154584942(-) A-G intron -    22484847
chr1:154585857(-) A-G intron -    22484847
chr1:154586007(-) A-G intron -    22484847
chr1:154586193(-) A-G intron -    22484847
chr1:154586280(-) A-G intron -    22484847
chr1:154586297(-) A-G intron -    22484847
chr1:154588006(-) A-G intron -    22484847
chr1:154598078(-) A-G intron -    22484847
chr1:154598309(-) A-G intron -    22484847
chr1:154598428(-) A-G intron -    22484847
chr1:154598466(-) A-G intron -    22484847
chr1:154598538(-) A-G intron -    22484847
chr1:154598541(-) A-G intron -    22484847
chr1:154598880(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADAR
chr1:154554554-154554555(-) m6A 3'UTR       28052920//22608085
chr1:154554661-154554662(-) m6A 3'UTR       24284625//25456834//24981863//28052920//22575960//22608085
chr1:154554675-154554676(-) m6A 3'UTR       24284625//25456834//24981863//28052920//22575960//22608085
chr1:154554729-154554730(-) m6A 3'UTR       24284625//25456834//22575960
chr1:154554813-154554814(-) m6A 3'UTR       24284625
chr1:154554935-154554936(-) m6A 3'UTR       27773535
chr1:154555094-154555095(-) m6A 3'UTR       27773535
chr1:154555117-154555118(-) m6A 3'UTR       27773535
chr1:154555775-154555776(-) Cm 3'UTR       -
chr1:154556050-154556051(-) m6A 3'UTR       26404942
chr1:154557049-154557050(-) m6A 3'UTR       24284625//26404942
chr1:154557140-154557141(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535
chr1:154557303-154557304(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154557320-154557321(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154557333-154557334(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154557372-154557373(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154557425-154557426(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154557483-154557484(-) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085
chr1:154562661-154562662(-) m6A CDS//intron       27773535//27773536
chr1:154562703-154562704(-) m6A CDS//intron       27773535//27773536
chr1:154569297-154569298(-) m6A CDS       27773535//22575960
chr1:154569379-154569380(-) m6A CDS       27773535//22575960
chr1:154569711-154569712(-) m6A CDS       26404942//22575960
chr1:154570308-154570309(-) m6A CDS       24284625//27773535
chr1:154570354-154570355(-) m6A CDS       24284625//27773535
chr1:154570436-154570437(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//27773536
chr1:154570932-154570933(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//27773536
chr1:154572662-154572663(-) m6A exon//intron       24284625//24981863
chr1:154572732-154572733(-) m6A exon//intron       24284625//24981863
chr1:154572976-154572977(-) m6A exon//intron       27371828
chr1:154573020-154573021(-) m6A exon//intron       27371828
chr1:154573045-154573046(-) m6A exon//intron       27371828
chr1:154573062-154573063(-) m6A exon//intron       27371828
chr1:154573305-154573306(-) m6A exon//intron       27773535
chr1:154573326-154573327(-) m6A exon//intron       24284625//27773535
chr1:154573333-154573334(-) m6A exon//intron       24284625//27773535
chr1:154573497-154573498(-) m6A exon//intron       24284625//24981863//27773535//22575960//22608085
chr1:154573508-154573509(-) m6A exon//intron       24284625//24981863//27773535//22575960//22608085
chr1:154573521-154573522(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085
chr1:154573533-154573534(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085
chr1:154573565-154573566(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr1:154573609-154573610(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154573632-154573633(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154573818-154573819(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154573824-154573825(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154573833-154573834(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154573839-154573840(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154573855-154573856(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:154573875-154573876(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:154573970-154573971(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:154573994-154573995(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr1:154574008-154574009(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154574047-154574048(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154574075-154574076(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154574082-154574083(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:154574233-154574234(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr1:154574278-154574279(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr1:154574286-154574287(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr1:154574299-154574300(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22575960//22608085
chr1:154574305-154574306(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22575960//22608085
chr1:154574329-154574330(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536//22575960//22608085
chr1:154574334-154574335(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536//22575960//22608085
chr1:154574356-154574357(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536//22575960//22608085
chr1:154574419-154574420(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//27773536//22575960//22608085
chr1:154574425-154574426(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//27773536//22575960//22608085
chr1:154574433-154574434(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//27773536//22575960//22608085
chr1:154574446-154574447(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//27773536//22575960//22608085
chr1:154574452-154574453(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//27773536//22575960//22608085
chr1:154574481-154574482(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr1:154574503-154574504(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr1:154574546-154574547(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:154574618-154574619(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:154574625-154574626(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:154574697-154574698(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:154574721-154574722(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:154574851-154574852(-) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085
chr1:154574907-154574908(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr1:154574936-154574937(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr1:154575048-154575049(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr1:154580630-154580631(-) m6A 5'UTR//intron       24209618//24981863//27371828//27773536//22575960
chr1:154580659-154580660(-) m6A 5'UTR//intron       24209618//24981863//27371828//27773536
chr1:154581254-154581255(-) m6A exon//intron       24209618//24981863
chr1:154600334-154600335(-) m6A 5'UTR//exon//intron       24209618//24981863
chr1:154600449-154600450(-) m6A exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ADAR
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART9-5p
Interactor2: ADAR

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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