Detail Information

Basic Information:


  VIRBase ID:  

VHID00391872

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:           MMS22L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-3p MMS22L
miRBase
Accession/Entrez ID		 MIMAT0003720 253714
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - C6orf167//dJ39B17.2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MMS22L
chr6:97640702(-) A-I      intronic
chr6:97640657(-) A-I      intronic
chr6:97640660(-) A-I      intronic
chr6:97640680(-) A-I      intronic
chr6:97640664(-) A-I      intronic
chr6:97640654(-) A-I      intronic
chr6:97640675(-) A-I      intronic
chr6:97640650(-) A-I      intronic
chr6:97642460(-) A-I      intronic
chr6:97640640(-) A-I      intronic
chr6:97642403(-) A-I      intronic
chr6:97640686(-) A-I      intronic
chr6:97706035(-) A-I      intronic
chr6:97640669(-) A-I      intronic
chr6:97640693(-) A-I      intronic
chr6:97640662(-) A-I      intronic
chr6:97640677(-) A-I      intronic
chr6:97713703(-) A-I      intronic
chr6:97699715(-) A-I      intronic
chr6:97700372(-) A-I      intronic
chr6:97674370(-) A-I      intronic
chr6:97673359(-) A-I      intronic
chr6:97673364(-) A-I      intronic
chr6:97673351(-) A-I      intronic
chr6:97713762(-) A-I      intronic
chr6:97699792(-) A-I      intronic
chr6:97727658(-) A-I      intronic
chr6:97728387(-) A-I      intronic
chr6:97704711(-) A-I      intronic
chr6:97713831(-) A-I      intronic
chr6:97713842(-) A-I      intronic
chr6:97713863(-) A-I      intronic
chr6:97699770(-) A-I      intronic
chr6:97704698(-) A-I      intronic
chr6:97687746(-) A-I      intronic
chr6:97687573(-) A-I      intronic
chr6:97687555(-) A-I      intronic
chr6:97727539(-) A-I      intronic
chr6:97674387(-) A-I      intronic
chr6:97727541(-) A-I      intronic
chr6:97727579(-) A-I      intronic
chr6:97699716(-) A-I      intronic
chr6:97728471(-) A-I      intronic
chr6:97728388(-) A-I      intronic
chr6:97728385(-) A-I      intronic
chr6:97728384(-) A-I      intronic
chr6:97728347(-) A-I      intronic
chr6:97728346(-) A-I      intronic
chr6:97727273(-) A-I      intronic
chr6:97728301(-) A-I      intronic
chr6:97652892(-) A-I      intronic
chr6:97725140(-) A-I      intronic
chr6:97700421(-) A-I      intronic
chr6:97687532(-) A-I      intronic
chr6:97713713(-) A-I      intronic
chr6:97673365(-) A-I      intronic
chr6:97704582(-) A-I      intronic
chr6:97642166(-) A-I      intronic
chr6:97705511(-) A-I      intronic
chr6:97704824(-) A-I      intronic
chr6:97710505(-) A-I      intronic
chr6:97727096(-) A-I      intronic
chr6:97674457(-) A-I      intronic
chr6:97704809(-) A-I      intronic
chr6:97704609(-) A-I      intronic
chr6:97699837(-) A-I      intronic
chr6:97652471(-) A-I      intronic
chr6:97704816(-) A-I      intronic
chr6:97700399(-) A-I      intronic
chr6:97652885(-) A-I      intronic
chr6:97687730(-) A-I      intronic
chr6:97705553(-) A-I      intronic
chr6:97727238(-) A-I      intronic
chr6:97665334(-) A-I      intronic
chr6:97687700(-) A-I      intronic
chr6:97687781(-) A-I      intronic
chr6:97728463(-) A-I      intronic
chr6:97700409(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MMS22L
chr6:97590412-97590413(-) m6A 3'UTR       27773535
chr6:97590444-97590445(-) m6A 3'UTR       27773535
chr6:97590464-97590465(-) m6A 3'UTR       27773535
chr6:97590495-97590496(-) m6A 3'UTR       27773535
chr6:97590554-97590555(-) m6A 3'UTR       27773535
chr6:97590667-97590668(-) m6A 3'UTR       27773535
chr6:97590695-97590696(-) m6A 3'UTR       27773535
chr6:97634518-97634519(-) m6A CDS       24284625//27773535//22608085
chr6:97634527-97634528(-) m6A CDS       24284625//27773535//22608085
chr6:97634538-97634539(-) m6A CDS       24284625//27773535//22608085
chr6:97676809-97676810(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960//22608085
chr6:97676816-97676817(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960//22608085
chr6:97676867-97676868(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr6:97676899-97676900(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:97676944-97676945(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:97676957-97676958(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:97677048-97677049(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr6:97677150-97677151(-) m6A CDS       24284625//27773535//22608085
chr6:97677219-97677220(-) m6A CDS       24284625//27773535//22608085
chr6:97677242-97677243(-) m6A CDS       24284625//27773535//22608085
chr6:97678186-97678187(-) m6A 3'UTR//intron       22608085
chr6:97678196-97678197(-) m6A 3'UTR//intron       22608085
chr6:97702598-97702599(-) m6A 3'UTR//CDS//exon       27773535
chr6:97706564-97706565(-) m6A exon//intron       27773535
chr6:97706569-97706570(-) m6A exon//intron       27773535
chr6:97706664-97706665(-) m6A exon//intron       27773535
chr6:97706768-97706769(-) m6A exon//intron       27773535
chr6:97706776-97706777(-) m6A exon//intron       27773535
chr6:97707221-97707222(-) m6A exon//intron       27773535
chr6:97707231-97707232(-) m6A exon//intron       27773535
chr6:97707340-97707341(-) m6A exon//intron       -
chr6:97707884-97707885(-) m6A exon//intron       24284625//27773535//22608085
chr6:97707904-97707905(-) m6A exon//intron       24284625//27773535//22608085
chr6:97707941-97707942(-) m6A exon//intron       24284625//27773535//22608085
chr6:97707946-97707947(-) m6A exon//intron       24284625//27773535//22608085
chr6:97707985-97707986(-) m6A exon//intron       24284625//27773535//22608085
chr6:97708000-97708001(-) m6A exon//intron       24284625//27773535//22608085
chr6:97708015-97708016(-) m6A exon//intron       24284625//27773535//22608085
chr6:97708103-97708104(-) m6A exon//intron       27773535//22608085
chr6:97708119-97708120(-) m6A exon//intron       27773535//22608085
chr6:97708145-97708146(-) m6A exon//intron       27773535//22608085
chr6:97708259-97708260(-) m6A exon//intron       27773535//22608085
chr6:97708303-97708304(-) m6A exon//intron       27773535//22608085
chr6:97708405-97708406(-) m6A exon//intron       27773535//22608085
chr6:97708412-97708413(-) m6A exon//intron       27773535//22608085
chr6:97708420-97708421(-) m6A exon//intron       27773535//22608085
chr6:97708451-97708452(-) m6A exon//intron       27773535//22608085
chr6:97708474-97708475(-) m6A exon//intron       27773535//22608085
chr6:97708513-97708514(-) m6A exon//intron       27773535//22608085
chr6:97708522-97708523(-) m6A exon//intron       27773535//22608085
chr6:97708533-97708534(-) m6A exon//intron       27773535//22608085
chr6:97708578-97708579(-) m6A exon//intron       27773535//22608085
chr6:97708593-97708594(-) m6A exon//intron       27773535//22608085
chr6:97708603-97708604(-) m6A exon//intron       27773535//22608085
chr6:97708608-97708609(-) m6A exon//intron       27773535//22608085
chr6:97708691-97708692(-) m6A exon//intron       25456834//27773535//22608085
chr6:97708761-97708762(-) m6A exon//intron       24284625//27773535//22608085
chr6:97708793-97708794(-) m6A exon//intron       24284625//27773535//22608085
chr6:97708913-97708914(-) m6A exon//intron       27773535//27371828//22608085
chr6:97708928-97708929(-) m6A exon//intron       24284625//27773535//27371828//22608085
chr6:97708990-97708991(-) m6A exon//intron       24284625//24981863//27773535//27371828//22608085
chr6:97709008-97709009(-) m6A exon//intron       24284625//24981863//27773535//27371828//22608085
chr6:97709025-97709026(-) m6A exon//intron       24981863//22608085
chr6:97709080-97709081(-) m6A exon//intron       22608085
chr6:97709087-97709088(-) m6A exon//intron       22608085
chr6:97709359-97709360(-) m6A exon//intron       27773535
chr6:97709384-97709385(-) m6A exon//intron       27773535//22608085
chr6:97709431-97709432(-) m6A exon//intron       27773535//22608085
chr6:97709481-97709482(-) m6A exon//intron       27773535//22608085
chr6:97709511-97709512(-) m6A exon//intron       24284625//27773535//22608085
chr6:97709562-97709563(-) m6A exon//intron       24284625//24209618//27773535//22608085
chr6:97709598-97709599(-) m6A exon//intron       24284625//24209618//27773535//22608085
chr6:97709637-97709638(-) m6A exon//intron       24284625//24209618//27773535//22608085
chr6:97709714-97709715(-) m6A exon//intron       27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MMS22L
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART20-3p
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-3p
Interactor2: MMS22L

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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