Basic Information:

  VIRBase ID:  

VHID00391348

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:  MIMAT0003720          SNX18:  NM_001102575     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-3p	SNX18
miRBase Accession/Entrez ID	MIMAT0003720	112574
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SH3PX2//SH3PXD3B//SNAG1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SNX18	chr5:53817573(+) A-I      intronic chr5:53835831(+) A-I      intronic chr5:53832904(+) A-I      intronic chr5:53834932(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SNX18	chr5:53813758-53813759(+) m6A 5'UTR       24209618//25456834//22608085 chr5:53813779-53813780(+) m6A 5'UTR       24209618//25456834//22608085 chr5:53813825-53813826(+) m6A CDS       24209618//25456834//22608085 chr5:53813882-53813883(+) m6A CDS       24209618//25456834//22608085 chr5:53814314-53814315(+) m6A CDS       25456834//22608085 chr5:53814548-53814549(+) m6A CDS       - chr5:53814596-53814597(+) m6A CDS       - chr5:53814821-53814822(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr5:53814863-53814864(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr5:53815223-53815224(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:53815250-53815251(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:53815322-53815323(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:53815340-53815341(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:53815382-53815383(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:53815737-53815738(+) m6A 3'UTR//intron       - chr5:53816818-53816819(+) m6A intron       24209618//25456834//24981863//22608085 chr5:53839158-53839159(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr5:53839283-53839284(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr5:53839323-53839324(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr5:53839389-53839390(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:53839422-53839423(+) m6A 3'UTR       24981863//22608085 chr5:53839448-53839449(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SNX18	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART20-3p	Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-3p
Interactor2: SNX18

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.