Detail Information

Basic Information:


  VIRBase ID:  

VHID00391037

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:           KDM7A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-3p KDM7A
miRBase
Accession/Entrez ID		 MIMAT0003720 80853
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - JHDM1D

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KDM7A
chr7:139794161(-) A-I      intronic
chr7:139866413(-) A-I      intronic
chr7:139866268(-) A-I      intronic
chr7:139866411(-) A-I      intronic
chr7:139863328(-) A-I      intronic
chr7:139866410(-) A-I      intronic
chr7:139861410(-) A-I      intronic
chr7:139857712(-) A-I      intronic
chr7:139838007(-) A-I      intronic
chr7:139835273(-) A-I      intronic
chr7:139830345(-) A-I      intronic
chr7:139830339(-) A-I      intronic
chr7:139795522(-) A-I      intronic
chr7:139830338(-) A-I      intronic
chr7:139830305(-) A-I      intronic
chr7:139866362(-) A-I      intronic
chr7:139794821(-) A-I      intronic
chr7:139794222(-) A-I      intronic
chr7:139823703(-) A-I      intronic
chr7:139823832(-) A-I      intronic
chr7:139794271(-) A-I      intronic
chr7:139866317(-) A-I      intronic
chr7:139794715(-) A-I      intronic
chr7:139794759(-) A-I      intronic
chr7:139794769(-) A-I      intronic
chr7:139794776(-) A-I      intronic
chr7:139794785(-) A-I      intronic
chr7:139794786(-) A-I      intronic
chr7:139794812(-) A-I      intronic
chr7:139794815(-) A-I      intronic
chr7:139794252(-) A-I      intronic
chr7:139794816(-) A-I      intronic
chr7:139866319(-) A-I      intronic
chr7:139866320(-) A-I      intronic
chr7:139818344(-) A-I      intronic
chr7:139866365(-) A-I      intronic
chr7:139818343(-) A-I      intronic
chr7:139869422(-) A-I      intronic
chr7:139869470(-) A-I      intronic
chr7:139874577(-) A-I      intronic
chr7:139794248(-) A-I      intronic
chr7:139794236(-) A-I      intronic
chr7:139873815(-) A-I      intronic
chr7:139873801(-) A-I      intronic
chr7:139794867(-) A-I      intronic
chr7:139873798(-) A-I      intronic
chr7:139871238(-) A-I      intronic
chr7:139870849(-) A-I      intronic
chr7:139869529(-) A-I      intronic
chr7:139794157(-) A-I      intronic
chr7:139869463(-) A-I      intronic
chr7:139869458(-) A-I      intronic
chr7:139869437(-) A-I      intronic
chr7:139794139(-) A-I      intronic
chr7:139794845(-) A-I      intronic
chr7:139794885(-) A-I      intronic
chr7:139794193(-) A-I      intronic
chr7:139862927(-) A-I      intronic
chr7:139813649(-) A-I      intronic
chr7:139861483(-) A-I      intronic
chr7:139862007(-) A-I      intronic
chr7:139795484(-) A-I      NonSyn:Asp->Gly
chr7:139861970(-) A-I      intronic
chr7:139794297(-) A-I      intronic
chr7:139794912(-) A-I      intronic
chr7:139862052(-) A-I      intronic
chr7:139823634(-) A-I      intronic
chr7:139795506(-) A-I      NonSyn:Arg->Gly
chr7:139827049(-) A-I      intronic
chr7:139823682(-) A-I      intronic
chr7:139794183(-) A-I      intronic
chr7:139794242(-) A-I      intronic
chr7:139794744(-) A-I      intronic
chr7:139866322(-) A-I      intronic
chr7:139794048(-) A-I      intronic
chr7:139795596(-) A-I      intronic
chr7:139866261(-) A-I      intronic
chr7:139795557(-) A-I      intronic
chr7:139794826(-) A-I      intronic
chr7:139874489(-) A-I      intronic
chr7:139868121(-) A-I      intronic
chr7:139794113(-) A-I      intronic
chr7:139795592(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KDM7A
chr7:139790101-139790102(-) m6A 3'UTR       27773535
chr7:139790126-139790127(-) m6A 3'UTR       27773535
chr7:139790146-139790147(-) m6A 3'UTR       27773535
chr7:139790342-139790343(-) m6A 3'UTR       27773535
chr7:139790376-139790377(-) m6A 3'UTR       27773535
chr7:139790656-139790657(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139790663-139790664(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139790676-139790677(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139790708-139790709(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139790761-139790762(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139790770-139790771(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139790784-139790785(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139790857-139790858(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr7:139790924-139790925(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139790953-139790954(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr7:139791646-139791647(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr7:139791681-139791682(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr7:139791746-139791747(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr7:139791794-139791795(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr7:139791916-139791917(-) m6A exon//intron       27773535
chr7:139797416-139797417(-) m6A CDS       24981863
chr7:139798688-139798689(-) m6A CDS       24981863//27773535
chr7:139798706-139798707(-) m6A CDS       24981863//27773535
chr7:139798759-139798760(-) m6A CDS       24981863//27773535
chr7:139799784-139799785(-) m6A CDS       27773535
chr7:139838923-139838924(-) Y CDS       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate KDM7A
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART20-3p
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-3p
Interactor2: KDM7A

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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