Basic Information:

  VIRBase ID:  

VHID00390403

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:  MIMAT0003720          C20orf27:  NR_047675     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-3p	C20orf27
miRBase Accession/Entrez ID	MIMAT0003720	54976
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C20orf27	chr20:3742068(-) A-I      intronic chr20:3742837(-) A-I      intronic chr20:3742795(-) A-I      intronic chr20:3734402(-) A-I      3'UTR chr20:3743150(-) A-I      intronic chr20:3738391(-) A-I      intronic chr20:3737841(-) A-I      intronic chr20:3737885(-) A-I      intronic chr20:3743182(-) A-I      intronic chr20:3738422(-) A-I      intronic chr20:3737961(-) A-I      intronic chr20:3738454(-) A-I      intronic chr20:3742121(-) A-I      intronic chr20:3738404(-) A-I      intronic chr20:3744157(-) A-I      intronic chr20:3742210(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C20orf27	chr20:3734385-3734386(-) m6A 3'UTR       24284625//25456834 chr20:3734664-3734665(-) m6A 3'UTR       - chr20:3740702-3740703(-) m6A CDS//intron       27773536 chr20:3747872-3747873(-) m6A 5'UTR//intron       27773536 chr20:3747952-3747953(-) m6A 5'UTR//intron       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	C20orf27	Chromatin K562 cells     - Exosome Blood     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART20-3p	Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-3p
Interactor2: C20orf27

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.