Basic Information:

  VIRBase ID:  

VHID00389991

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:  MIMAT0003720          ASF1A:  NM_014034     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-3p	ASF1A
miRBase Accession/Entrez ID	MIMAT0003720	25842
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-98//CIA//HSPC146

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ASF1A	chr6:119215402-119215403(+) m6A 5'UTR//exon       24209618//24981863//22608085 chr6:119215522-119215523(+) m6A 5'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:119215596-119215597(+) m6A CDS//exon       27773535//27371828//27773536//22608085 chr6:119215674-119215675(+) m6A CDS//exon       27773535//27371828//27773536 chr6:119226899-119226900(+) m6A CDS       27773535 chr6:119226948-119226949(+) m6A CDS       24284625//27773535 chr6:119226977-119226978(+) m6A CDS       24284625//27773535 chr6:119226982-119226983(+) m6A CDS       24284625//27773535 chr6:119228640-119228641(+) m6A CDS       24284625//24981863//27773535//22608085 chr6:119228735-119228736(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:119228768-119228769(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:119228827-119228828(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:119228863-119228864(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr6:119228889-119228890(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr6:119228915-119228916(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr6:119228927-119228928(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ASF1A	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART20-3p	Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-3p
Interactor2: ASF1A

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.