Detail Information

Basic Information:


  VIRBase ID:  

VHID00389732

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:           MGAT4A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-3p MGAT4A
miRBase
Accession/Entrez ID		 MIMAT0003720 11320
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - GnT-4a//GNT-IV//GNT-IVA

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MGAT4A
chr2:99269223(-) A-I      intronic
chr2:99248526(-) A-I      intronic
chr2:99249344(-) A-I      intronic
chr2:99248527(-) A-I      intronic
chr2:99294089(-) A-I      intronic
chr2:99294098(-) A-I      intronic
chr2:99294104(-) A-I      intronic
chr2:99248491(-) A-I      intronic
chr2:99294109(-) A-I      intronic
chr2:99294129(-) A-I      intronic
chr2:99294083(-) A-I      intronic
chr2:99294084(-) A-I      intronic
chr2:99294134(-) A-I      intronic
chr2:99307695(-) A-I      intronic
chr2:99294030(-) A-I      intronic
chr2:99249351(-) A-I      intronic
chr2:99248532(-) A-I      intronic
chr2:99294027(-) A-I      intronic
chr2:99307682(-) A-I      intronic
chr2:99294048(-) A-I      intronic
chr2:99294054(-) A-I      intronic
chr2:99294072(-) A-I      intronic
chr2:99294093(-) A-I      intronic
chr2:99294111(-) A-I      intronic
chr2:99294183(-) A-I      intronic
chr2:99294459(-) A-I      intronic
chr2:99264727(-) A-I      intronic
chr2:99294467(-) A-I      intronic
chr2:99294499(-) A-I      intronic
chr2:99294508(-) A-I      intronic
chr2:99294553(-) A-I      intronic
chr2:99294571(-) A-I      intronic
chr2:99294609(-) A-I      intronic
chr2:99294624(-) A-I      intronic
chr2:99323467(-) A-I      intronic
chr2:99248357(-) A-I      intronic
chr2:99249278(-) A-I      intronic
chr2:99249383(-) A-I      intronic
chr2:99249390(-) A-I      intronic
chr2:99249393(-) A-I      intronic
chr2:99249398(-) A-I      intronic
chr2:99323596(-) A-I      intronic
chr2:99328212(-) A-I      intronic
chr2:99328318(-) A-I      intronic
chr2:99328343(-) A-I      intronic
chr2:99328351(-) A-I      intronic
chr2:99332507(-) A-I      intronic
chr2:99311036(-) A-I      intronic
chr2:99341507(-) A-I      intronic
chr2:99341524(-) A-I      intronic
chr2:99341532(-) A-I      intronic
chr2:99306051(-) A-I      intronic
chr2:99322966(-) A-I      intronic
chr2:99307681(-) A-I      intronic
chr2:99306094(-) A-I      intronic
chr2:99249401(-) A-I      intronic
chr2:99306089(-) A-I      intronic
chr2:99323499(-) A-I      intronic
chr2:99323496(-) A-I      intronic
chr2:99283104(-) A-I      intronic
chr2:99249416(-) A-I      intronic
chr2:99252638(-) A-I      intronic
chr2:99262955(-) A-I      intronic
chr2:99322185(-) A-I      intronic
chr2:99269251(-) A-I      intronic
chr2:99269250(-) A-I      intronic
chr2:99269248(-) A-I      intronic
chr2:99269247(-) A-I      intronic
chr2:99265490(-) A-I      intronic
chr2:99265476(-) A-I      intronic
chr2:99265003(-) A-I      intronic
chr2:99322960(-) A-I      intronic
chr2:99322217(-) A-I      intronic
chr2:99283120(-) A-I      intronic
chr2:99307820(-) A-I      intronic
chr2:99307792(-) A-I      intronic
chr2:99307725(-) A-I      intronic
chr2:99239400(-) A-I      3'UTR
chr2:99240756(-) A-I      3'UTR
chr2:99240613(-) A-I      3'UTR
chr2:99240533(-) A-I      3'UTR
chr2:99240597(-) A-I      3'UTR
chr2:99294581(-) A-I      intronic
chr2:99249286(-) A-I      intronic
chr2:99249285(-) A-I      intronic
chr2:99296088(-) A-I      intronic
chr2:99331734(-) A-I      intronic
chr2:99310048(-) A-I      intronic
chr2:99243977(-) A-I      intronic
chr2:99249463(-) A-I      intronic
chr2:99261207(-) A-I      intronic
chr2:99322150(-) A-I      intronic
chr2:99248338(-) A-I      intronic
chr2:99294528(-) A-I      intronic
chr2:99294525(-) A-I      intronic
chr2:99329422(-) A-I      intronic
chr2:99312483(-) A-I      intronic
chr2:99329537(-) A-I      intronic
chr2:99311121(-) A-I      intronic
chr2:99310046(-) A-I      intronic
chr2:99329549(-) A-I      intronic
chr2:99310095(-) A-I      intronic
chr2:99310088(-) A-I      intronic
chr2:99310119(-) A-I      intronic
chr2:99249400(-) A-I      intronic
chr2:99329462(-) A-I      intronic
chr2:99312482(-) A-I      intronic
chr2:99240543(-) A-I      3'UTR
chr2:99239395(-) A-I      3'UTR
chr2:99240548(-) A-I      3'UTR
chr2:99240505(-) A-I      3'UTR
chr2:99239396(-) A-I      3'UTR
chr2:99240747(-) A-I      3'UTR
chr2:99239475(-) A-I      3'UTR
chr2:99239373(-) A-I      3'UTR
chr2:99239382(-) A-I      3'UTR
chr2:99252728(-) A-I      intronic
chr2:99294435(-) A-I      intronic
chr2:99311608(-) A-I      intronic
chr2:99322931(-) A-I      intronic
chr2:99326965(-) A-I      intronic
chr2:99294503(-) A-I      intronic
chr2:99249510(-) A-I      intronic
chr2:99249399(-) A-I      intronic
chr2:99249472(-) A-I      intronic
chr2:99269338(-) A-I      intronic
chr2:99323066(-) A-I      intronic
chr2:99249347(-) A-I      intronic
chr2:99296048(-) A-I      intronic
chr2:99323620(-) A-I      intronic
chr2:99308862(-) A-I      intronic
chr2:99262910(-) A-I      intronic
chr2:99308721(-) A-I      intronic
chr2:99311250(-) A-I      intronic
chr2:99330616(-) A-I      intronic
chr2:99248451(-) A-I      intronic
chr2:99322933(-) A-I      intronic
chr2:99327157(-) A-I      intronic
chr2:99307827(-) A-I      intronic
chr2:99324703(-) A-I      intronic
chr2:99294080(-) A-I      intronic
chr2:99294119(-) A-I      intronic
chr2:99256907(-) A-I      intronic
chr2:99331697(-) A-I      intronic
chr2:99264071(-) A-I      intronic
chr2:99331737(-) A-I      intronic
chr2:99262954(-) A-I      intronic
chr2:99249405(-) A-I      intronic
chr2:99299469(-) A-I      intronic
chr2:99263943(-) A-I      intronic
chr2:99329404(-) A-I      intronic
chr2:99248339(-) A-I      intronic
chr2:99264055(-) A-I      intronic
chr2:99249290(-) A-I      intronic
chr2:99323625(-) A-I      intronic
chr2:99294158(-) A-I      intronic
chr2:99294195(-) A-I      intronic
chr2:99323081(-) A-I      intronic
chr2:99322921(-) A-I      intronic
chr2:99294110(-) A-I      intronic
chr2:99310085(-) A-I      intronic
chr2:99269217(-) A-I      intronic
chr2:99329459(-) A-I      intronic
chr2:99249493(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MGAT4A
chr2:99294503(-) A-I intron -    15258596
chr2:99294525(-) A-I intron -    15258596
chr2:99294528(-) A-I intron -    15258596
chr2:99294531(-) A-I intron -    15258596
chr2:99294581(-) A-I intron -    15258596
chr2:99310046(-) A-I intron -    22028664
chr2:99310048(-) A-I intron -    22028664
chr2:99310088(-) A-I intron -    22028664
chr2:99310095(-) A-I intron -    22028664
chr2:99310119(-) A-I intron -    22028664
chr2:99263048(-) A-I intron -    21960545
chr2:99239382(-) A-G exon 3'UTR    22484847
chr2:99249361(-) A-G intron -    22484847
chr2:99249400(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MGAT4A
chr2:99237251-99237252(-) m6A 3'UTR       27773535
chr2:99237309-99237310(-) m6A 3'UTR       27773535
chr2:99237315-99237316(-) m6A 3'UTR       27773535//27371828
chr2:99237329-99237330(-) m6A 3'UTR       27773535//27371828
chr2:99237343-99237344(-) m6A 3'UTR       27773535//27371828
chr2:99237442-99237443(-) m6A 3'UTR       27773535
chr2:99237633-99237634(-) m6A 3'UTR       24981863//27773535//27371828//22608085
chr2:99237649-99237650(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr2:99237669-99237670(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr2:99237683-99237684(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr2:99237721-99237722(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr2:99237787-99237788(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22608085
chr2:99237810-99237811(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22608085
chr2:99237917-99237918(-) m6A 3'UTR//CDS       25456834//26404942//27773535//27371828//22608085
chr2:99237930-99237931(-) m6A 3'UTR//CDS       25456834//26404942//27773535//27371828//22608085
chr2:99238011-99238012(-) m6A 3'UTR//intron       27773535//22608085
chr2:99238056-99238057(-) m6A 3'UTR//intron       27773535//22608085
chr2:99238189-99238190(-) m6A 3'UTR//intron       27773535//22608085
chr2:99238204-99238205(-) m6A 3'UTR//intron       27773535//22608085
chr2:99238295-99238296(-) m6A 3'UTR//intron       27773535
chr2:99240842-99240843(-) m6A 3'UTR//intron       27773535
chr2:99240874-99240875(-) m6A 3'UTR//intron       27773535
chr2:99240894-99240895(-) m6A 3'UTR//intron       27773535
chr2:99240922-99240923(-) m6A 3'UTR//intron       27773535
chr2:99241651-99241652(-) m6A 3'UTR//intron       27773535
chr2:99241714-99241715(-) m6A 3'UTR//intron       27773535
chr2:99291503-99291504(-) m6A CDS//exon       27773535
chr2:99291575-99291576(-) Y CDS//exon       26075521
chr2:99294802-99294803(-) m6A CDS//exon       27773535
chr2:99294872-99294873(-) m6A CDS//exon       27773535
chr2:99294929-99294930(-) m6A CDS//exon       27773535
chr2:99342415-99342416(-) m6A 3'UTR//intron       27773535
chr2:99342437-99342438(-) m6A 3'UTR//intron       27773535
chr2:99342470-99342471(-) m6A 3'UTR//intron       27773535
chr2:99342536-99342537(-) m6A 3'UTR//intron       27773535
chr2:99342543-99342544(-) m6A 3'UTR//intron       27773535
chr2:99342556-99342557(-) m6A 3'UTR//intron       27773535
chr2:99342776-99342777(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr2:99342816-99342817(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr2:99342824-99342825(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr2:99342849-99342850(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr2:99342922-99342923(-) m6A 5'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr2:99342965-99342966(-) m6A 5'UTR//exon       24209618//24981863//27773535//27371828//27773536//22608085
chr2:99342996-99342997(-) m6A 5'UTR//exon       24981863//27773535//27371828//27773536//22608085
chr2:99343082-99343083(-) m6A 5'UTR//intron       27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MGAT4A
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART20-3p
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-3p
Interactor2: MGAT4A

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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