Detail Information

Basic Information:


  VIRBase ID:  

VHID00389381

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:           PREPL:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-3p PREPL
miRBase
Accession/Entrez ID		 MIMAT0003720 9581
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - CMS22

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PREPL
chr2:44579628(-) A-I      intronic
chr2:44545351(-) A-I      3'UTR
chr2:44545341(-) A-I      3'UTR
chr2:44545260(-) A-I      3'UTR
chr2:44545358(-) A-I      3'UTR
chr2:44545297(-) A-I      3'UTR
chr2:44545344(-) A-I      3'UTR
chr2:44545315(-) A-I      3'UTR
chr2:44545335(-) A-I      3'UTR
chr2:44582626(-) A-I      intronic
chr2:44581886(-) A-I      intronic
chr2:44579626(-) A-I      intronic
chr2:44581083(-) A-I      intronic
chr2:44581884(-) A-I      intronic
chr2:44545386(-) A-I      3'UTR
chr2:44545336(-) A-I      3'UTR
chr2:44545313(-) A-I      3'UTR
chr2:44573109(-) A-I      intronic
chr2:44581935(-) A-I      intronic
chr2:44581842(-) A-I      intronic
chr2:44573064(-) A-I      intronic
chr2:44553741(-) A-I      intronic
chr2:44553614(-) A-I      intronic
chr2:44581989(-) A-I      intronic
chr2:44582503(-) A-I      intronic
chr2:44582523(-) A-I      intronic
chr2:44582524(-) A-I      intronic
chr2:44579595(-) A-I      intronic
chr2:44580544(-) A-I      intronic
chr2:44580651(-) A-I      intronic
chr2:44580664(-) A-I      intronic
chr2:44581089(-) A-I      intronic
chr2:44582529(-) A-I      intronic
chr2:44582544(-) A-I      intronic
chr2:44582560(-) A-I      intronic
chr2:44582575(-) A-I      intronic
chr2:44583436(-) A-I      intronic
chr2:44583608(-) A-I      intronic
chr2:44579557(-) A-I      intronic
chr2:44545383(-) A-I      3'UTR
chr2:44545481(-) A-I      3'UTR
chr2:44545332(-) A-I      3'UTR
chr2:44545368(-) A-I      3'UTR
chr2:44545374(-) A-I      3'UTR
chr2:44545292(-) A-I      3'UTR
chr2:44545306(-) A-I      3'UTR
chr2:44545318(-) A-I      3'UTR
chr2:44582642(-) A-I      intronic
chr2:44586371(-) A-I      intronic
chr2:44575271(-) A-I      intronic
chr2:44581281(-) A-I      intronic
chr2:44574252(-) A-I      intronic
chr2:44581120(-) A-I      intronic
chr2:44578282(-) A-I      intronic
chr2:44579616(-) A-I      intronic
chr2:44581088(-) A-I      intronic
chr2:44579430(-) A-I      intronic
chr2:44553746(-) A-I      intronic
chr2:44553729(-) A-I      intronic
chr2:44581878(-) A-I      intronic
chr2:44574253(-) A-I      intronic
chr2:44572499(-) A-I      intronic
chr2:44581904(-) A-I      intronic
chr2:44582674(-) A-I      intronic
chr2:44579521(-) A-I      intronic
chr2:44553690(-) A-I      intronic
chr2:44579620(-) A-I      intronic
chr2:44583563(-) A-I      intronic
chr2:44579439(-) A-I      intronic
chr2:44572759(-) A-I      intronic
chr2:44545458(-) A-I      3'UTR
chr2:44545450(-) A-I      3'UTR
chr2:44545326(-) A-I      3'UTR
chr2:44545449(-) A-I      3'UTR
chr2:44584082(-) A-I      intronic
chr2:44558421(-) A-I      intronic
chr2:44586344(-) A-I      intronic
chr2:44582564(-) A-I      intronic
chr2:44581184(-) A-I      intronic
chr2:44584120(-) A-I      intronic
chr2:44582520(-) A-I      intronic
chr2:44574314(-) A-I      intronic
chr2:44582612(-) A-I      intronic
chr2:44551820(-) A-I      intronic
chr2:44584218(-) A-I      intronic
chr2:44579465(-) A-I      intronic
chr2:44553680(-) A-I      intronic
chr2:44584141(-) A-I      intronic
chr2:44582443(-) A-I      intronic
chr2:44551760(-) A-I      intronic
chr2:44581819(-) A-I      intronic
chr2:44586335(-) A-I      intronic
chr2:44581810(-) A-I      intronic
chr2:44581825(-) A-I      intronic
chr2:44584146(-) A-I      intronic
chr2:44582514(-) A-I      intronic
chr2:44581781(-) A-I      intronic
chr2:44581043(-) A-I      intronic
chr2:44555245(-) A-I      intronic
chr2:44582566(-) A-I      intronic
chr2:44581852(-) A-I      intronic
chr2:44581934(-) A-I      intronic
chr2:44553747(-) A-I      intronic
chr2:44579619(-) A-I      intronic
chr2:44586345(-) A-I      intronic
chr2:44581082(-) A-I      intronic
chr2:44584081(-) A-I      intronic
chr2:44581811(-) A-I      intronic
chr2:44579596(-) A-I      intronic
chr2:44583518(-) A-I      intronic
chr2:44584217(-) A-I      intronic
chr2:44579604(-) A-I      intronic
chr2:44574464(-) A-I      intronic
chr2:44579543(-) A-I      intronic
chr2:44582469(-) A-I      intronic
chr2:44582442(-) A-I      intronic
chr2:44584196(-) A-I      intronic
chr2:44551829(-) A-I      intronic
chr2:44579692(-) A-I      intronic
chr2:44574225(-) A-I      intronic
chr2:44582631(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PREPL
chr2:44582566(-) A-I intron -    21960545
chr2:44584226(-) A-I intron -    21960545
chr2:44579597(-) A-G intron -    22484847
chr2:44579604(-) A-G intron -    22484847
chr2:44579620(-) A-G intron -    22484847
chr2:44579692(-) A-G intron -    22484847
chr2:44581082(-) A-G intron -    22484847
chr2:44581088(-) A-G intron -    22484847
chr2:44581281(-) A-G intron -    22484847
chr2:44581781(-) A-G intron -    22484847
chr2:44581811(-) A-G intron -    22484847
chr2:44581819(-) A-G intron -    22484847
chr2:44581825(-) A-G intron -    22484847
chr2:44581912(-) A-G intron -    22484847
chr2:44581934(-) A-G intron -    22484847
chr2:44581991(-) A-G intron -    22484847
chr2:44582443(-) A-G intron -    22484847
chr2:44582469(-) A-G intron -    22484847
chr2:44582514(-) A-G intron -    22484847
chr2:44582564(-) A-G intron -    22484847
chr2:44582576(-) A-G intron -    22484847
chr2:44582612(-) A-G intron -    22484847
chr2:44582619(-) A-G intron -    22484847
chr2:44582631(-) A-G intron -    22484847
chr2:44582642(-) A-G intron -    22484847
chr2:44582674(-) A-G intron -    22484847
chr2:44582682(-) A-G intron -    22484847
chr2:44583464(-) A-G intron -    22484847
chr2:44583518(-) A-G intron -    22484847
chr2:44583563(-) A-G intron -    22484847
chr2:44583576(-) A-G intron -    22484847
chr2:44583680(-) A-G intron -    22484847
chr2:44583682(-) A-G intron -    22484847
chr2:44584141(-) A-G intron -    22484847
chr2:44584146(-) A-G intron -    22484847
chr2:44584187(-) A-G intron -    22484847
chr2:44584217(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PREPL
chr2:44545234-44545235(-) m6A 3'UTR//intron       24981863
chr2:44545256-44545257(-) m6A 3'UTR//intron       24981863
chr2:44545325-44545326(-) m6A 3'UTR//intron       24981863
chr2:44545938-44545939(-) m6A 3'UTR//intron       27773535
chr2:44546491-44546492(-) m6A 3'UTR       27773535
chr2:44549030-44549031(-) m6A CDS//intron       27773535
chr2:44549880-44549881(-) m6A CDS       27773535
chr2:44549912-44549913(-) m6A CDS       27773535
chr2:44550406-44550407(-) m6A CDS       27773535
chr2:44550443-44550444(-) m6A CDS       27773535
chr2:44550451-44550452(-) m6A CDS       27773535
chr2:44550515-44550516(-) m6A CDS       27773535
chr2:44559632-44559633(-) m6A CDS//intron       24981863
chr2:44559646-44559647(-) m6A CDS//intron       24981863
chr2:44559659-44559660(-) m6A CDS//intron       24981863
chr2:44559672-44559673(-) m6A CDS//intron       24981863
chr2:44559742-44559743(-) m6A CDS//intron       24981863
chr2:44571719-44571720(-) m6A CDS//intron       24981863
chr2:44573444-44573445(-) m6A CDS//exon       24981863//27773535
chr2:44573456-44573457(-) m6A CDS//exon       24981863//27773535
chr2:44573482-44573483(-) m6A 5'UTR//CDS//exon       24981863//27773535
chr2:44573496-44573497(-) m6A 5'UTR//CDS//exon       24981863//27773535
chr2:44573511-44573512(-) m6A 5'UTR//CDS//exon       24981863//27773535
chr2:44574354-44574355(-) m6A exon//intron       24981863//27773535
chr2:44583475-44583476(-) m6A exon//intron       24981863
chr2:44586663-44586664(-) m6A CDS//intron       24981863//27773535
chr2:44586689-44586690(-) m6A CDS//intron       24981863//27773535
chr2:44586779-44586780(-) m6A CDS//intron       24981863//27773535//22608085
chr2:44586841-44586842(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr2:44586864-44586865(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr2:44586871-44586872(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr2:44586936-44586937(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085
chr2:44586961-44586962(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085
chr2:44587065-44587066(-) m6A 5'UTR//intron       24981863//22608085
chr2:44587425-44587426(-) m6A 5'UTR//intron       27773535
chr2:44587508-44587509(-) m6A 5'UTR//intron       27773535
chr2:44588536-44588537(-) m6A 5'UTR//exon//intron       24981863
chr2:44588617-44588618(-) m6A 5'UTR//exon//intron       24981863
chr2:44588628-44588629(-) m6A 5'UTR//exon//intron       24981863
chr2:44588682-44588683(-) m6A 5'UTR//exon       24981863
chr2:44588762-44588763(-) m6A 5'UTR//exon       24981863
chr2:44588772-44588773(-) m6A 5'UTR//exon       24981863
chr2:44588780-44588781(-) m6A 5'UTR//exon       24981863
chr2:44588788-44588789(-) m6A 5'UTR//exon       24981863
chr2:44588823-44588824(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PREPL
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART20-3p
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-3p
Interactor2: PREPL

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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