Detail Information

Basic Information:


  VIRBase ID:  

VHID00388593

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:           MLLT6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-3p MLLT6
miRBase
Accession/Entrez ID		 MIMAT0003720 4302
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - AF17

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MLLT6
chr17:36880358(+) A-I      intronic
chr17:36880026(+) A-I      intronic
chr17:36880014(+) A-I      intronic
chr17:36879708(+) A-I      intronic
chr17:36879634(+) A-I      intronic
chr17:36879647(+) A-I      intronic
chr17:36880434(+) A-I      intronic
chr17:36880421(+) A-I      intronic
chr17:36880057(+) A-I      intronic
chr17:36880359(+) A-I      intronic
chr17:36880113(+) A-I      intronic
chr17:36880076(+) A-I      intronic
chr17:36880052(+) A-I      intronic
chr17:36880429(+) A-I      intronic
chr17:36880390(+) A-I      intronic
chr17:36879651(+) A-I      intronic
chr17:36880354(+) A-I      intronic
chr17:36880496(+) A-I      intronic
chr17:36880360(+) A-I      intronic
chr17:36880398(+) A-I      intronic
chr17:36879730(+) A-I      intronic
chr17:36879657(+) A-I      intronic
chr17:36880357(+) A-I      intronic
chr17:36880231(+) A-I      intronic
chr17:36880062(+) A-I      intronic
chr17:36879727(+) A-I      intronic
chr17:36880135(+) A-I      intronic
chr17:36879665(+) A-I      intronic
chr17:36880461(+) A-I      intronic
chr17:36879501(+) A-I      intronic
chr17:36880430(+) A-I      intronic
chr17:36880363(+) A-I      intronic
chr17:36880095(+) A-I      intronic
chr17:36880018(+) A-I      intronic
chr17:36879624(+) A-I      intronic
chr17:36880458(+) A-I      intronic
chr17:36880497(+) A-I      intronic
chr17:36879616(+) A-I      intronic
chr17:36880096(+) A-I      intronic
chr17:36879729(+) A-I      intronic
chr17:36879528(+) A-I      intronic
chr17:36879666(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MLLT6
chr17:36879665(+) A-G intron -    22484847
chr17:36880354(+) A-G intron -    22484847
chr17:36884054(+) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MLLT6
chr17:36861943-36861944(+) m6A CDS//exon       24209618
chr17:36862916-36862917(+) m1A exon//intron       26863410//26863196
chr17:36862926-36862927(+) m6A exon//intron       24209618
chr17:36863233-36863234(+) m6A CDS//exon       22575960
chr17:36863780-36863781(+) m6A CDS//exon       -
chr17:36865425-36865426(+) m6A CDS//exon       24209618
chr17:36865781-36865782(+) m6A CDS//exon       24209618
chr17:36868102-36868103(+) m6A CDS//exon       24209618//22575960
chr17:36868264-36868265(+) m1A CDS//exon       26863196
chr17:36868953-36868954(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828
chr17:36870986-36870987(+) m6A 3'UTR//intron       -
chr17:36871915-36871916(+) m6A CDS//exon       -
chr17:36871986-36871987(+) m6A CDS//exon       24284625
chr17:36872151-36872152(+) m6A exon//intron       24284625
chr17:36872478-36872479(+) m6A exon//intron       24284625
chr17:36872484-36872485(+) m6A exon//intron       24284625
chr17:36872501-36872502(+) m6A exon//intron       24284625
chr17:36872508-36872509(+) m6A exon//intron       24284625
chr17:36872529-36872530(+) m6A exon//intron       24284625
chr17:36872682-36872683(+) m6A CDS       24284625//24981863
chr17:36872859-36872860(+) m6A CDS       -
chr17:36872954-36872955(+) m6A CDS       25456834
chr17:36872963-36872964(+) m6A CDS       25456834
chr17:36873039-36873040(+) m6A CDS       25456834
chr17:36874151-36874152(+) m6A CDS//exon       24981863
chr17:36874252-36874253(+) m6A exon//intron       -
chr17:36875775-36875776(+) m6A CDS//exon       24284625
chr17:36875784-36875785(+) m6A CDS//exon       24284625
chr17:36875807-36875808(+) m6A CDS//exon       24284625
chr17:36876039-36876040(+) m6A CDS//exon       24284625
chr17:36876073-36876074(+) m6A CDS//exon       24284625
chr17:36876666-36876667(+) m6A CDS//exon       24284625
chr17:36876974-36876975(+) m6A CDS//exon       24284625
chr17:36877038-36877039(+) m6A CDS//intron       24284625
chr17:36878948-36878949(+) m6A CDS//exon       24284625
chr17:36880534-36880535(+) m6A exon//intron       24284625
chr17:36880874-36880875(+) m6A CDS//exon       -
chr17:36880881-36880882(+) m6A CDS//exon       -
chr17:36881147-36881148(+) m6A CDS//exon       24284625
chr17:36881169-36881170(+) m6A CDS//exon       24284625
chr17:36881809-36881810(+) m6A CDS//exon       -
chr17:36881890-36881891(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085
chr17:36881940-36881941(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr17:36882009-36882010(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr17:36882015-36882016(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr17:36882089-36882090(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr17:36882189-36882190(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr17:36882289-36882290(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960
chr17:36882338-36882339(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863
chr17:36882347-36882348(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863
chr17:36882556-36882557(+) m6A 3'UTR//exon//intron       24284625//24209618//22575960
chr17:36882681-36882682(+) m6A 3'UTR//exon//intron       24284625//24209618
chr17:36882743-36882744(+) m6A 3'UTR//exon//intron       24284625//24209618
chr17:36882818-36882819(+) m6A 3'UTR//exon//intron       24284625
chr17:36884853-36884854(+) m6A 3'UTR       24209618
chr17:36884939-36884940(+) m6A 3'UTR       24981863
chr17:36884952-36884953(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MLLT6
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART20-3p
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-3p
Interactor2: MLLT6

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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