Basic Information:

  VIRBase ID:  

VHID00387997

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-3p:  MIMAT0003720          ALDH1B1:  NM_000692     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-3p	ALDH1B1
miRBase Accession/Entrez ID	MIMAT0003720	219
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALDH5//ALDHX

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ALDH1B1	chr9:38392707-38392708(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr9:38392737-38392738(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr9:38392757-38392758(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr9:38392763-38392764(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr9:38392781-38392782(+) m6A 5'UTR       24284625//25456834//24981863//26404942//22608085 chr9:38394475-38394476(+) m6A 5'UTR//intron       - chr9:38394510-38394511(+) m6A 5'UTR//intron       - chr9:38395790-38395791(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chr9:38395836-38395837(+) m6A CDS       24284625//24981863//26404942 chr9:38395842-38395843(+) m6A CDS       24284625//24981863//26404942 chr9:38395901-38395902(+) m6A CDS       24284625//24981863//26404942//22575960 chr9:38396061-38396062(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396073-38396074(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396114-38396115(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396121-38396122(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396157-38396158(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396222-38396223(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396301-38396302(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396329-38396330(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396384-38396385(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396451-38396452(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396717-38396718(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr9:38396759-38396760(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr9:38396793-38396794(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396808-38396809(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396832-38396833(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396893-38396894(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397105-38397106(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397143-38397144(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397156-38397157(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397291-38397292(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397385-38397386(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr9:38397422-38397423(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr9:38397477-38397478(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr9:38397570-38397571(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397581-38397582(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397623-38397624(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397672-38397673(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397703-38397704(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397754-38397755(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397899-38397900(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr9:38398017-38398018(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:38398026-38398027(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:38398043-38398044(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:38398072-38398073(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:38398128-38398129(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr9:38398220-38398221(+) m6A 3'UTR       24209618//24981863//22608085 chr9:38398260-38398261(+) m6A 3'UTR       24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ALDH1B1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART20-3p	Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-3p
Interactor2: ALDH1B1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.