Basic Information:

  VIRBase ID:  

VHID00387258

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:  MIMAT0003719          UBXN2B:  NR_156456     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-5p	UBXN2B
miRBase Accession/Entrez ID	MIMAT0003719	137886
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	p37

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBXN2B	chr8:59345203(+) A-I      intronic chr8:59337741(+) A-I      intronic chr8:59337699(+) A-I      intronic chr8:59338892(+) A-I      intronic chr8:59339908(+) A-I      intronic chr8:59339936(+) A-I      intronic chr8:59339948(+) A-I      intronic chr8:59343779(+) A-I      intronic chr8:59343787(+) A-I      intronic chr8:59356088(+) A-I      intronic chr8:59345172(+) A-I      intronic chr8:59337690(+) A-I      intronic chr8:59345202(+) A-I      intronic chr8:59332238(+) A-I      intronic chr8:59345215(+) A-I      intronic chr8:59346237(+) A-I      intronic chr8:59346240(+) A-I      intronic chr8:59337670(+) A-I      intronic chr8:59338883(+) A-I      intronic chr8:59356096(+) A-I      intronic chr8:59356102(+) A-I      intronic chr8:59356113(+) A-I      intronic chr8:59337664(+) A-I      intronic chr8:59338827(+) A-I      intronic chr8:59332228(+) A-I      intronic chr8:59338870(+) A-I      intronic chr8:59360807(+) A-I      3'UTR chr8:59360789(+) A-I      3'UTR chr8:59360797(+) A-I      3'UTR chr8:59360826(+) A-I      3'UTR chr8:59339827(+) A-I      intronic chr8:59346313(+) A-I      intronic chr8:59339859(+) A-I      intronic chr8:59339901(+) A-I      intronic chr8:59356090(+) A-I      intronic chr8:59346152(+) A-I      intronic chr8:59339029(+) A-I      intronic chr8:59343788(+) A-I      intronic chr8:59339764(+) A-I      intronic chr8:59353833(+) A-I      intronic chr8:59353762(+) A-I      intronic chr8:59359497(+) A-I      intronic chr8:59339880(+) A-I      intronic chr8:59330677(+) A-I      intronic chr8:59330787(+) A-I      intronic chr8:59343830(+) A-I      intronic chr8:59343811(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBXN2B	chr8:59339764(+) A-G intron -    22484847 chr8:59343788(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBXN2B	chr8:59325878-59325879(+) m6A exon//intron       24209618//25456834//24981863 chr8:59325890-59325891(+) m6A exon//intron       24209618//24981863 chr8:59325898-59325899(+) m6A exon//intron       24209618//24981863 chr8:59329467-59329468(+) m6A CDS//exon       24981863 chr8:59360168-59360169(+) m6A 3'UTR       24284625//24981863//22608085 chr8:59360188-59360189(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UBXN2B	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-5p
Interactor2: UBXN2B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.