Detail Information

Basic Information:


  VIRBase ID:  

VHID00386745

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:           ZNF436:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-5p ZNF436
miRBase
Accession/Entrez ID		 MIMAT0003719 80818
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - Zfp46//ZNF

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF436
chr1:23689920(-) A-I      intronic
chr1:23690440(-) A-I      intronic
chr1:23689906(-) A-I      intronic
chr1:23690868(-) A-I      intronic
chr1:23690851(-) A-I      intronic
chr1:23690842(-) A-I      intronic
chr1:23690453(-) A-I      intronic
chr1:23690276(-) A-I      intronic
chr1:23689981(-) A-I      intronic
chr1:23691026(-) A-I      intronic
chr1:23690348(-) A-I      intronic
chr1:23690473(-) A-I      intronic
chr1:23690413(-) A-I      intronic
chr1:23690423(-) A-I      intronic
chr1:23690315(-) A-I      intronic
chr1:23689946(-) A-I      intronic
chr1:23690452(-) A-I      intronic
chr1:23692316(-) A-I      intronic
chr1:23690288(-) A-I      intronic
chr1:23690316(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF436
chr1:23687652-23687653(-) m6A 3'UTR       27773535
chr1:23687781-23687782(-) m6A 3'UTR       24981863//27773535//22608085
chr1:23687788-23687789(-) m6A 3'UTR       24981863//27773535//22608085
chr1:23687802-23687803(-) m6A 3'UTR       24981863//27773535//22608085
chr1:23688049-23688050(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688095-23688096(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688117-23688118(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688195-23688196(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688203-23688204(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688339-23688340(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:23688386-23688387(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:23688465-23688466(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr1:23688485-23688486(-) m6A CDS       24981863//27773535//22608085
chr1:23688542-23688543(-) m6A CDS       27773535//27371828//22608085
chr1:23688643-23688644(-) m6A CDS       27773535//27371828
chr1:23688653-23688654(-) m6A CDS       27773535//27371828
chr1:23688811-23688812(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23688921-23688922(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23688989-23688990(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23689046-23689047(-) m6A CDS       24981863//27773535//27371828//22608085
chr1:23689063-23689064(-) m6A CDS       24981863//27773535//27371828//22608085
chr1:23689130-23689131(-) m6A CDS       24981863//27773535//27371828//22608085
chr1:23689147-23689148(-) m6A CDS       24981863//27773535//27371828//22608085
chr1:23689234-23689235(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23689315-23689316(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23689386-23689387(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:23689399-23689400(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:23689419-23689420(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23689562-23689563(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr1:23689631-23689632(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23689645-23689646(-) m6A CDS       24284625//24981863//27773535//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZNF436
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-5p
Interactor2: ZNF436

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//PARalyzer//PITA//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

Starting a new search, please wait ...