Detail Information

Basic Information:


  VIRBase ID:  

VHID00385889

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9906

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:           TBX21:      

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Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-5p TBX21
miRBase
Accession/Entrez ID		 MIMAT0003719 30009
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - T-bet//T-PET//TBET//TBLYM

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TBX21
chr17:45817598(+) A-I      intronic
chr17:45817572(+) A-I      intronic
chr17:45817562(+) A-I      intronic
chr17:45817574(+) A-I      intronic
chr17:45817599(+) A-I      intronic
chr17:45817614(+) A-I      intronic
chr17:45816079(+) A-I      intronic
chr17:45818002(+) A-I      intronic
chr17:45818008(+) A-I      intronic
chr17:45818011(+) A-I      intronic
chr17:45818017(+) A-I      intronic
chr17:45815689(+) A-I      intronic
chr17:45817845(+) A-I      intronic
chr17:45817976(+) A-I      intronic
chr17:45817875(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TBX21
chr17:45811154-45811155(+) m6A CDS//exon       -
chr17:45811190-45811191(+) m6A CDS//exon       -
chr17:45811209-45811210(+) m6A CDS//exon       -
chr17:45811227-45811228(+) m6A CDS//exon       -
chr17:45811282-45811283(+) m6A CDS//exon       -
chr17:45822480-45822481(+) m6A CDS       -
chr17:45822494-45822495(+) m6A CDS       -
chr17:45822524-45822525(+) m6A CDS       -
chr17:45822532-45822533(+) m6A CDS       -
chr17:45822555-45822556(+) m6A CDS       -
chr17:45822596-45822597(+) m6A CDS       -
chr17:45822610-45822611(+) m6A CDS       -
chr17:45822704-45822705(+) m6A CDS       -
chr17:45822753-45822754(+) m6A 3'UTR       26404942
chr17:45822759-45822760(+) m6A 3'UTR       26404942
chr17:45822780-45822781(+) m6A 3'UTR       26404942
chr17:45822810-45822811(+) m6A 3'UTR       26404942
chr17:45822921-45822922(+) m6A 3'UTR       -
chr17:45823019-45823020(+) m6A 3'UTR       -
chr17:45823083-45823084(+) m6A 3'UTR       -
chr17:45823098-45823099(+) m6A 3'UTR       -
chr17:45823173-45823174(+) m6A 3'UTR       -
chr17:45823222-45823223(+) m6A 3'UTR       -
chr17:45823238-45823239(+) m6A 3'UTR       -
chr17:45823266-45823267(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TBX21
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-5p
Interactor2: TBX21

Evidence Support:


Strong-Evidence IHC//qRT-PCR//RT-PCR//Western blot
Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 23608226 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line BJAB cells//d3-YT cells//Jurkat cells//L428 cells//NK92 cells//YT cells Interactor2 expression Downregulation
Description In this study, we measured the levels of 39 EBV-encoded miRNAs in NNLs. We found that the EBV-encoded miR-BART20-5p inhibits T-bet with secondary suppression of p53 in invasive NNLs. miR-BART20-5p is a marker for disease progression, and antagomirs to miR-BART20-5p might be useful therapeutically.

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