Detail Information

Basic Information:


  VIRBase ID:  

VHID00385282

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:           BTN2A2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-5p BTN2A2
miRBase
Accession/Entrez ID		 MIMAT0003719 10385
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - BT2.2//BTF2//BTN2.2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BTN2A2
chr6:26386046(+) A-I      intronic
chr6:26389183(+) A-I      intronic
chr6:26389146(+) A-I      intronic
chr6:26387780(+) A-I      intronic
chr6:26384559(+) A-I      intronic
chr6:26387687(+) A-I      intronic
chr6:26384490(+) A-I      intronic
chr6:26387744(+) A-I      intronic
chr6:26387703(+) A-I      intronic
chr6:26385978(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BTN2A2
chr6:26387687(+) A-I intron -    22327324
chr6:26385978(+) A-G intron -    22484847
chr6:26387687(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BTN2A2
chr6:26383338-26383339(+) m6A 5'UTR//exon       24981863
chr6:26383347-26383348(+) m6A 5'UTR//exon       24981863
chr6:26383358-26383359(+) m6A 5'UTR//exon       24981863
chr6:26383390-26383391(+) m6A 5'UTR//exon       24981863
chr6:26383413-26383414(+) m6A 5'UTR//intron       24981863
chr6:26385412-26385413(+) m6A 3'UTR//CDS//exon//intron       24981863
chr6:26385464-26385465(+) m6A 3'UTR//CDS//exon//intron       24981863
chr6:26390510-26390511(+) m6A exon//intron       25456834//24981863
chr6:26390604-26390605(+) m6A exon//intron       25456834
chr6:26390715-26390716(+) m6A exon//intron       -
chr6:26392474-26392475(+) m6A 3'UTR//CDS//intron       24981863
chr6:26392504-26392505(+) m6A 3'UTR//CDS//intron       24981863
chr6:26392524-26392525(+) m6A 3'UTR//intron       24981863
chr6:26392536-26392537(+) m6A 3'UTR//intron       22608085
chr6:26392543-26392544(+) m6A 3'UTR//intron       22608085
chr6:26392569-26392570(+) m6A 3'UTR//intron       25456834//22608085
chr6:26392582-26392583(+) m6A 3'UTR//intron       25456834//22608085
chr6:26392589-26392590(+) m6A 3'UTR//intron       25456834//22608085
chr6:26392623-26392624(+) m6A 3'UTR//CDS//intron       25456834//24981863//22608085
chr6:26392656-26392657(+) m6A 3'UTR//CDS//intron       25456834//24981863//22608085
chr6:26392765-26392766(+) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//22608085
chr6:26392805-26392806(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:26392822-26392823(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:26392877-26392878(+) m6A 3'UTR//CDS//intron       24209618//25456834//24981863//27773535//22608085
chr6:26392896-26392897(+) m6A 3'UTR//CDS//intron       24209618//25456834//24981863//22608085
chr6:26392974-26392975(+) m6A 3'UTR//CDS//intron       24209618//25456834//24981863//22608085
chr6:26393013-26393014(+) m6A 3'UTR//CDS//intron       24209618//24981863//22608085
chr6:26393161-26393162(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26393177-26393178(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26393209-26393210(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26393274-26393275(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26393307-26393308(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085
chr6:26393431-26393432(+) m6A 3'UTR//intron       24981863//27773535//22608085
chr6:26393489-26393490(+) m6A 3'UTR//intron       25456834//24981863//27773535//22608085
chr6:26393555-26393556(+) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22608085
chr6:26393613-26393614(+) m6A 3'UTR//intron       25456834//24981863//27773535//22608085
chr6:26393633-26393634(+) m6A 3'UTR//intron       25456834//24981863//27773535//22608085
chr6:26393667-26393668(+) m6A 3'UTR//intron       25456834//24981863//27773535//22608085
chr6:26393685-26393686(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085
chr6:26393798-26393799(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085
chr6:26393822-26393823(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085
chr6:26393828-26393829(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085
chr6:26393869-26393870(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085
chr6:26393939-26393940(+) m6A 3'UTR//intron       25456834//24981863//26404942//27773535//22608085
chr6:26393973-26393974(+) m6A 3'UTR//intron       25456834//24981863//26404942//27773535//22608085
chr6:26393989-26393990(+) m6A 3'UTR//intron       25456834//24981863//26404942//27773535//22608085
chr6:26394015-26394016(+) m6A 3'UTR//intron       25456834//24981863//26404942//22608085
chr6:26394035-26394036(+) m6A 3'UTR//intron       24981863//26404942//22608085
chr6:26394715-26394716(+) m6A 3'UTR       25456834//24981863//22608085
chr6:26394739-26394740(+) m6A 3'UTR       25456834//24981863//22608085
chr6:26394747-26394748(+) m6A 3'UTR       25456834//24981863//22608085
chr6:26394770-26394771(+) m6A 3'UTR       25456834//24981863//22608085
chr6:26394778-26394779(+) m6A 3'UTR       25456834//24981863//22608085
chr6:26394821-26394822(+) m6A 3'UTR       25456834//24981863//22608085
chr6:26394865-26394866(+) m6A 3'UTR       25456834//24981863//22608085
chr6:26394871-26394872(+) m6A 3'UTR       25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BTN2A2
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-5p
Interactor2: BTN2A2

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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