Basic Information:

  VIRBase ID:  

VHID00385253

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:  MIMAT0003719          TRIM13:  NM_005798     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-5p	TRIM13
miRBase Accession/Entrez ID	MIMAT0003719	10206
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAR//DLEU5//LEU5//RFP2//RNF77

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRIM13	chr13:50571566(+) A-I      5'UTR chr13:50584302(+) A-I      intronic chr13:50584297(+) A-I      intronic chr13:50578444(+) A-I      intronic chr13:50579650(+) A-I      intronic chr13:50579652(+) A-I      intronic chr13:50579726(+) A-I      intronic chr13:50584249(+) A-I      intronic chr13:50584285(+) A-I      intronic chr13:50584314(+) A-I      intronic chr13:50584324(+) A-I      intronic chr13:50584373(+) A-I      intronic chr13:50584442(+) A-I      intronic chr13:50584458(+) A-I      intronic chr13:50579699(+) A-I      intronic chr13:50578462(+) A-I      intronic chr13:50579552(+) A-I      intronic chr13:50579671(+) A-I      intronic chr13:50578325(+) A-I      intronic chr13:50578446(+) A-I      intronic chr13:50578450(+) A-I      intronic chr13:50579546(+) A-I      intronic chr13:50579548(+) A-I      intronic chr13:50579554(+) A-I      intronic chr13:50579600(+) A-I      intronic chr13:50579624(+) A-I      intronic chr13:50579634(+) A-I      intronic chr13:50588396(+) A-I      3'UTR chr13:50588332(+) A-I      3'UTR chr13:50588348(+) A-I      3'UTR chr13:50588434(+) A-I      3'UTR chr13:50579648(+) A-I      intronic chr13:50581055(+) A-I      intronic chr13:50579713(+) A-I      intronic chr13:50579663(+) A-I      intronic chr13:50582180(+) A-I      intronic chr13:50576928(+) A-I      intronic chr13:50579645(+) A-I      intronic chr13:50576414(+) A-I      intronic chr13:50580062(+) A-I      intronic chr13:50579954(+) A-I      intronic chr13:50581867(+) A-I      intronic chr13:50588364(+) A-I      3'UTR chr13:50587935(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIM13	chr13:50571323-50571324(+) m6A 5'UTR//intron       27371828//27773536 chr13:50571425-50571426(+) m6A 5'UTR//intron       27371828//27773536//22608085 chr13:50571503-50571504(+) m6A 5'UTR//intron       27371828//27773536//22608085 chr13:50586219-50586220(+) m6A CDS//intron       22608085 chr13:50586256-50586257(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr13:50586363-50586364(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586450-50586451(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586526-50586527(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr13:50586571-50586572(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr13:50586691-50586692(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586699-50586700(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586738-50586739(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586807-50586808(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586868-50586869(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586914-50586915(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586938-50586939(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586945-50586946(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586963-50586964(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50586980-50586981(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:50587133-50587134(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr13:50587156-50587157(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr13:50587173-50587174(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr13:50587194-50587195(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr13:50587259-50587260(+) m6A CDS//intron       24209618//24981863//22608085 chr13:50587290-50587291(+) m6A CDS//intron       24209618//24981863//22608085 chr13:50590372-50590373(+) m6A 3'UTR//intron       24981863//22608085 chr13:50590415-50590416(+) m6A 3'UTR//intron       24981863//22608085 chr13:50590434-50590435(+) m6A 3'UTR//intron       24981863//22608085 chr13:50590448-50590449(+) m6A 3'UTR//intron       24981863//22608085 chr13:50590454-50590455(+) m6A 3'UTR//intron       24981863//22608085 chr13:50590461-50590462(+) m6A 3'UTR//intron       22608085 chr13:50594458-50594459(+) m6A exon       22608085 chr13:50594474-50594475(+) m6A exon       22608085 chr13:50594479-50594480(+) m6A exon       22608085 chr13:50594536-50594537(+) m6A exon       22608085 chr13:50594544-50594545(+) m6A exon       22608085 chr13:50594551-50594552(+) m6A exon       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TRIM13	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-5p
Interactor2: TRIM13

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.