Basic Information:

  VIRBase ID:  

VHID00384829

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:  MIMAT0003719          PTP4A1:  NR_169595     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-5p	PTP4A1
miRBase Accession/Entrez ID	MIMAT0003719	7803
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HH72//PRL-1//PRL1//PTP(CAAX1)//PTPCAAX1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PTP4A1	chr6:64237883-64237884(+) m6A exon       24981863 chr6:64282007-64282008(+) m6A 5'UTR//intron       24284625//27773535//22608085 chr6:64282045-64282046(+) m6A 5'UTR//intron       24284625//24981863//27773535//22608085 chr6:64282576-64282577(+) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr6:64282614-64282615(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr6:64283219-64283220(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr6:64286428-64286429(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:64286436-64286437(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:64286445-64286446(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:64286493-64286494(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:64286557-64286558(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:64286702-64286703(+) m6A 5'UTR       24284625//24209618//24981863//22575960//22608085 chr6:64286798-64286799(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr6:64286831-64286832(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr6:64286876-64286877(+) m6A CDS       24981863//27773535//22575960 chr6:64287373-64287374(+) Tm intron       - chr6:64288343-64288344(+) m6A CDS       24981863//27773535//22575960 chr6:64288888-64288889(+) m6A CDS       22575960 chr6:64289233-64289234(+) m6A CDS//intron       22575960 chr6:64290059-64290060(+) m6A CDS       26404942//22575960 chr6:64290110-64290111(+) m6A 3'UTR       26404942//22575960 chr6:64290488-64290489(+) m6A 3'UTR       27773535 chr6:64290495-64290496(+) m6A 3'UTR       27773535 chr6:64290502-64290503(+) m6A 3'UTR       27773535 chr6:64290535-64290536(+) m6A 3'UTR       26404942//27773535 chr6:64291113-64291114(+) m6A 3'UTR       27773535 chr6:64291307-64291308(+) m6A 3'UTR       27773535//22575960 chr6:64291326-64291327(+) m6A 3'UTR       27773535 chr6:64291401-64291402(+) m6A 3'UTR       27773535 chr6:64291496-64291497(+) m6A 3'UTR       22575960 chr6:64291524-64291525(+) m6A 3'UTR       22575960 chr6:64291582-64291583(+) m6A 3'UTR       26404942 chr6:64291883-64291884(+) m6A 3'UTR       22575960 chr6:64292133-64292134(+) m6A 3'UTR       27773535 chr6:64292167-64292168(+) m6A 3'UTR       27773535 chr6:64292190-64292191(+) m6A 3'UTR       27773535 chr6:64292241-64292242(+) m6A 3'UTR       27773535 chr6:64292959-64292960(+) m6A 3'UTR       27773535 chr6:64293122-64293123(+) m6A 3'UTR       26404942//27773535 chr6:64293153-64293154(+) m6A 3'UTR       27773535 chr6:64293267-64293268(+) m6A 3'UTR       27773535 chr6:64293365-64293366(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PTP4A1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-5p
Interactor2: PTP4A1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.