Basic Information:

  VIRBase ID:  

VHID00384775

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:  MIMAT0003719          TXNRD1:  NM_003330     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-5p	TXNRD1
miRBase Accession/Entrez ID	MIMAT0003719	7296
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GRIM-12//TR//TR1//TRXR1//TXNR

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TXNRD1	chr12:104690287(+) A-I      intronic chr12:104690872(+) A-I      intronic chr12:104692340(+) A-I      intronic chr12:104740025(+) A-I      intronic chr12:104731388(+) A-I      intronic chr12:104731385(+) A-I      intronic chr12:104731380(+) A-I      intronic chr12:104740782(+) A-I      intronic chr12:104739865(+) A-I      3'UTR chr12:104739877(+) A-I      3'UTR chr12:104731371(+) A-I      intronic chr12:104692381(+) A-I      intronic chr12:104711760(+) A-I      intronic chr12:104711757(+) A-I      intronic chr12:104621466(+) A-I      intronic chr12:104612854(+) A-I      intronic chr12:104711732(+) A-I      intronic chr12:104711693(+) A-I      intronic chr12:104739890(+) A-I      3'UTR chr12:104694586(+) A-I      intronic chr12:104692343(+) A-I      intronic chr12:104692342(+) A-I      intronic chr12:104692331(+) A-I      intronic chr12:104685451(+) A-I      intronic chr12:104685462(+) A-I      intronic chr12:104685442(+) A-I      intronic chr12:104685428(+) A-I      intronic chr12:104686236(+) A-I      intronic chr12:104687295(+) A-I      intronic chr12:104693402(+) A-I      intronic chr12:104740784(+) A-I      intronic chr12:104740785(+) A-I      intronic chr12:104676727(+) A-I      ncRNA chr12:104740013(+) A-I      intronic chr12:104740012(+) A-I      intronic chr12:104740011(+) A-I      intronic chr12:104654134(+) A-I      intronic chr12:104732756(+) A-I      intronic chr12:104684208(+) A-I      intronic chr12:104732755(+) A-I      intronic chr12:104732737(+) A-I      intronic chr12:104724464(+) A-I      intronic chr12:104732702(+) A-I      intronic chr12:104731379(+) A-I      intronic chr12:104732693(+) A-I      intronic chr12:104732670(+) A-I      intronic chr12:104732556(+) A-I      intronic chr12:104732341(+) A-I      intronic chr12:104732287(+) A-I      intronic chr12:104628310(+) A-I      intronic chr12:104731706(+) A-I      intronic chr12:104731682(+) A-I      intronic chr12:104726447(+) A-I      intronic chr12:104731665(+) A-I      intronic chr12:104726433(+) A-I      intronic chr12:104726424(+) A-I      intronic chr12:104724571(+) A-I      intronic chr12:104691403(+) A-I      intronic chr12:104690896(+) A-I      intronic chr12:104667156(+) A-I      intronic chr12:104724563(+) A-I      intronic chr12:104724445(+) A-I      intronic chr12:104723413(+) A-I      intronic chr12:104723226(+) A-I      intronic chr12:104723167(+) A-I      intronic chr12:104722443(+) A-I      intronic chr12:104711654(+) A-I      intronic chr12:104688496(+) A-I      intronic chr12:104710285(+) A-I      intronic chr12:104710272(+) A-I      intronic chr12:104710269(+) A-I      intronic chr12:104704162(+) A-I      intronic chr12:104704069(+) A-I      intronic chr12:104704067(+) A-I      intronic chr12:104704057(+) A-I      intronic chr12:104694626(+) A-I      intronic chr12:104693434(+) A-I      intronic chr12:104693424(+) A-I      intronic chr12:104693269(+) A-I      intronic chr12:104691426(+) A-I      intronic chr12:104691377(+) A-I      intronic chr12:104691333(+) A-I      intronic chr12:104691323(+) A-I      intronic chr12:104691280(+) A-I      intronic chr12:104691053(+) A-I      intronic chr12:104690976(+) A-I      intronic chr12:104690963(+) A-I      intronic chr12:104690832(+) A-I      intronic chr12:104690827(+) A-I      intronic chr12:104690826(+) A-I      intronic chr12:104614934(+) A-I      intronic chr12:104687346(+) A-I      intronic chr12:104686420(+) A-I      intronic chr12:104686241(+) A-I      intronic chr12:104686228(+) A-I      intronic chr12:104685427(+) A-I      intronic chr12:104723250(+) A-I      intronic chr12:104685162(+) A-I      intronic chr12:104685153(+) A-I      intronic chr12:104732211(+) A-I      intronic chr12:104685072(+) A-I      intronic chr12:104684357(+) A-I      intronic chr12:104684241(+) A-I      intronic chr12:104723318(+) A-I      intronic chr12:104684220(+) A-I      intronic chr12:104683681(+) A-I      intronic chr12:104683628(+) A-I      intronic chr12:104688523(+) A-I      intronic chr12:104683610(+) A-I      intronic chr12:104677110(+) A-I      intronic chr12:104702916(+) A-I      intronic chr12:104671807(+) A-I      intronic chr12:104665235(+) A-I      intronic chr12:104665217(+) A-I      intronic chr12:104711759(+) A-I      intronic chr12:104665154(+) A-I      intronic chr12:104663675(+) A-I      intronic chr12:104653951(+) A-I      intronic chr12:104731826(+) A-I      intronic chr12:104650539(+) A-I      intronic chr12:104650538(+) A-I      intronic chr12:104648633(+) A-I      intronic chr12:104648621(+) A-I      intronic chr12:104648337(+) A-I      intronic chr12:104647668(+) A-I      intronic chr12:104643620(+) A-I      intronic chr12:104732420(+) A-I      intronic chr12:104640095(+) A-I      intronic chr12:104640085(+) A-I      intronic chr12:104635093(+) A-I      intronic chr12:104635086(+) A-I      intronic chr12:104690841(+) A-I      intronic chr12:104666689(+) A-I      intronic chr12:104619899(+) A-I      intronic chr12:104628173(+) A-I      intronic chr12:104621819(+) A-I      intronic chr12:104621307(+) A-I      intronic chr12:104692275(+) A-I      intronic chr12:104621280(+) A-I      intronic chr12:104612497(+) A-I      intronic chr12:104612481(+) A-I      intronic chr12:104740000(+) A-I      intronic chr12:104724395(+) A-I      intronic chr12:104732559(+) A-I      intronic chr12:104684309(+) A-I      intronic chr12:104692454(+) A-I      intronic chr12:104692248(+) A-I      intronic chr12:104645721(+) A-I      intronic chr12:104723339(+) A-I      intronic chr12:104650508(+) A-I      intronic chr12:104693486(+) A-I      intronic chr12:104690972(+) A-I      intronic chr12:104691326(+) A-I      intronic chr12:104631642(+) A-I      intronic chr12:104690286(+) A-I      intronic chr12:104722416(+) A-I      intronic chr12:104732701(+) A-I      intronic chr12:104740823(+) A-I      intronic chr12:104740822(+) A-I      intronic chr12:104740798(+) A-I      intronic chr12:104740794(+) A-I      intronic chr12:104740779(+) A-I      intronic chr12:104740623(+) A-I      intronic chr12:104740029(+) A-I      intronic chr12:104739891(+) A-I      3'UTR chr12:104739885(+) A-I      3'UTR chr12:104739908(+) A-I      3'UTR chr12:104684796(+) A-I      NonSyn:Arg->Gly chr12:104676689(+) A-I      ncRNA chr12:104739814(+) A-I      NonSyn:Stp->Trp chr12:104642283(+) A-I      intronic chr12:104740762(+) A-I      intronic chr12:104731419(+) A-I      intronic chr12:104699811(+) A-I      intronic chr12:104694564(+) A-I      intronic chr12:104711437(+) A-I      intronic chr12:104690290(+) A-I      intronic chr12:104684264(+) A-I      intronic chr12:104639128(+) A-I      intronic chr12:104719441(+) A-I      intronic chr12:104667172(+) A-I      intronic chr12:104661092(+) A-I      intronic chr12:104693425(+) A-I      intronic chr12:104690936(+) A-I      intronic chr12:104684215(+) A-I      intronic chr12:104693451(+) A-I      intronic chr12:104711662(+) A-I      intronic chr12:104614942(+) A-I      intronic chr12:104654031(+) A-I      intronic chr12:104711758(+) A-I      intronic chr12:104685522(+) A-I      intronic chr12:104731704(+) A-I      intronic chr12:104693335(+) A-I      intronic chr12:104692355(+) A-I      intronic chr12:104740617(+) A-I      intronic chr12:104690917(+) A-I      intronic chr12:104711663(+) A-I      intronic chr12:104708795(+) A-I      intronic chr12:104685179(+) A-I      intronic chr12:104661160(+) A-I      intronic chr12:104648813(+) A-I      intronic chr12:104687341(+) A-I      intronic chr12:104623038(+) A-I      intronic chr12:104685452(+) A-I      intronic chr12:104740653(+) A-I      intronic chr12:104737760(+) A-I      intronic chr12:104691003(+) A-I      intronic chr12:104685507(+) A-I      intronic chr12:104731808(+) A-I      intronic chr12:104740752(+) A-I      intronic chr12:104711756(+) A-I      intronic chr12:104740658(+) A-I      intronic chr12:104693441(+) A-I      intronic chr12:104642627(+) A-I      intronic chr12:104691244(+) A-I      intronic chr12:104639125(+) A-I      intronic chr12:104666688(+) A-I      intronic chr12:104691243(+) A-I      intronic chr12:104732427(+) A-I      intronic chr12:104722426(+) A-I      intronic chr12:104690849(+) A-I      intronic chr12:104691395(+) A-I      intronic chr12:104721684(+) A-I      intronic chr12:104691273(+) A-I      intronic chr12:104686435(+) A-I      intronic chr12:104612770(+) A-I      intronic chr12:104628275(+) A-I      intronic chr12:104711436(+) A-I      intronic chr12:104693457(+) A-I      intronic chr12:104688511(+) A-I      intronic chr12:104690898(+) A-I      intronic chr12:104722458(+) A-I      intronic chr12:104687386(+) A-I      intronic chr12:104612496(+) A-I      intronic chr12:104623026(+) A-I      intronic chr12:104621843(+) A-I      intronic chr12:104683611(+) A-I      intronic chr12:104623012(+) A-I      intronic chr12:104648628(+) A-I      intronic chr12:104740644(+) A-I      intronic chr12:104731363(+) A-I      intronic chr12:104635288(+) A-I      intronic chr12:104692382(+) A-I      intronic chr12:104615279(+) A-I      intronic chr12:104685503(+) A-I      intronic chr12:104639108(+) A-I      intronic chr12:104631710(+) A-I      intronic chr12:104645695(+) A-I      intronic chr12:104711539(+) A-I      intronic chr12:104685342(+) A-I      intronic chr12:104691405(+) A-I      intronic chr12:104615262(+) A-I      intronic chr12:104691299(+) A-I      intronic chr12:104722482(+) A-I      intronic chr12:104662182(+) A-I      intronic chr12:104668288(+) A-I      intronic chr12:104740677(+) A-I      intronic chr12:104691247(+) A-I      intronic chr12:104615025(+) A-I      intronic chr12:104621062(+) A-I      intronic chr12:104692375(+) A-I      intronic chr12:104692249(+) A-I      intronic chr12:104690875(+) A-I      intronic chr12:104723173(+) A-I      intronic chr12:104732683(+) A-I      intronic chr12:104740618(+) A-I      intronic chr12:104711376(+) A-I      intronic chr12:104740026(+) A-I      intronic chr12:104654195(+) A-I      intronic chr12:104664809(+) A-I      intronic chr12:104650446(+) A-I      intronic chr12:104693291(+) A-I      intronic chr12:104724640(+) A-I      intronic chr12:104723220(+) A-I      intronic chr12:104690731(+) A-I      intronic chr12:104732286(+) A-I      intronic chr12:104667161(+) A-I      intronic chr12:104723342(+) A-I      intronic chr12:104662783(+) A-I      intronic chr12:104739920(+) A-I      3'UTR chr12:104739860(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TXNRD1	chr12:104688496(+) A-I intron -    21960545 chr12:104691395(+) A-G intron -    22484847 chr12:104692382(+) A-G intron -    22484847 chr12:104693425(+) A-G intron -    22484847 chr12:104718267(+) C-T intron -    22484847 chr12:104718280(+) C-T intron -    22484847 chr12:104718315(+) A-T intron -    22484847 chr12:104684208(+) A-G intron -    22484847 chr12:104684215(+) A-G intron -    22484847 chr12:104687341(+) A-G intron -    22484847 chr12:104688496(+) A-G intron -    22484847 chr12:104688511(+) A-G intron -    22484847 chr12:104688523(+) A-G intron -    22484847 chr12:104690286(+) A-G intron -    22484847 chr12:104690290(+) A-G intron -    22484847 chr12:104690841(+) A-G intron -    22484847 chr12:104690849(+) A-G intron -    22484847 chr12:104690875(+) A-G intron -    22484847 chr12:104690972(+) A-G intron -    22484847 chr12:104691003(+) A-G intron -    22484847 chr12:104691243(+) A-G intron -    22484847 chr12:104691244(+) A-G intron -    22484847 chr12:104691247(+) A-G intron -    22484847 chr12:104691273(+) A-G intron -    22484847 chr12:104691299(+) A-G intron -    22484847 chr12:104691403(+) A-G intron -    22484847 chr12:104691405(+) A-G intron -    22484847 chr12:104692249(+) A-G intron -    22484847 chr12:104692275(+) A-G intron -    22484847 chr12:104692375(+) A-G intron -    22484847 chr12:104693335(+) A-G intron -    22484847 chr12:104704021(+) G-A intron -    22484847 chr12:104711756(+) A-G intron -    22484847 chr12:104711758(+) A-G intron -    22484847 chr12:104711759(+) A-G intron -    22484847 chr12:104718148(+) G-T intron -    22484847 chr12:104719480(+) A-T intron -    22484847 chr12:104724395(+) A-G intron -    22484847 chr12:104724464(+) A-G intron -    22484847 chr12:104731434(+) G-A intron -    22484847 chr12:104731704(+) A-G intron -    22484847 chr12:104732211(+) A-G intron -    22484847 chr12:104732286(+) A-G intron -    22484847 chr12:104732683(+) A-G intron -    22484847 chr12:104732701(+) A-G intron -    22484847 chr12:104739860(+) A-G intron -    22484847 chr12:104740617(+) A-G intron -    22484847 chr12:104740752(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TXNRD1	chr12:104659285-104659286(+) Y intron       26075521 chr12:104680780-104680781(+) m6A 5'UTR//intron       24284625//24981863//26404942 chr12:104680908-104680909(+) m6A 5'UTR//intron       24284625//24981863//26404942//27773535//22575960 chr12:104680913-104680914(+) m6A 5'UTR//intron       24284625//24981863//26404942//27773535//22575960 chr12:104681059-104681060(+) m6A 5'UTR//intron       24981863 chr12:104682755-104682756(+) m6A 5'UTR//CDS//exon//intron       24981863//27773535//22575960 chr12:104682781-104682782(+) m6A 5'UTR//CDS//exon//intron       24981863//27773535//22575960 chr12:104697958-104697959(+) m6A intron       24981863//22575960 chr12:104698034-104698035(+) m6A intron       24981863//22575960//22608085 chr12:104698046-104698047(+) m6A intron       24981863//22575960//22608085 chr12:104698210-104698211(+) m6A intron       25456834//24981863//22575960//22608085 chr12:104698272-104698273(+) m6A intron       25456834//24981863//22575960//22608085 chr12:104698337-104698338(+) m6A intron       25456834//24981863//22575960//22608085 chr12:104698399-104698400(+) m6A intron       24981863//22608085 chr12:104698460-104698461(+) m6A intron       24981863//22608085 chr12:104705084-104705085(+) m6A 5'UTR//CDS//intron       26404942 chr12:104707059-104707060(+) m6A CDS//intron       26404942//22575960 chr12:104707085-104707086(+) m6A CDS//intron       26404942 chr12:104709565-104709566(+) m6A CDS//intron       26404942//27773535 chr12:104709597-104709598(+) m6A CDS//intron       26404942//27773535//22575960 chr12:104709624-104709625(+) m6A CDS//intron       26404942//27773535//22575960 chr12:104709638-104709639(+) m6A CDS//intron       26404942//27773535//22575960 chr12:104709670-104709671(+) m6A CDS//intron       26404942//27773535//22575960 chr12:104712705-104712706(+) m6A CDS//intron       27773535//22575960 chr12:104715020-104715021(+) m6A CDS//intron       26404942//27773535 chr12:104715042-104715043(+) m6A CDS//intron       26404942//27773535 chr12:104715054-104715055(+) m6A CDS//intron       26404942//27773535 chr12:104715075-104715076(+) m6A CDS//intron       24981863//26404942//27773535 chr12:104719119-104719120(+) m6A 5'UTR//CDS       24981863//26404942//27773535 chr12:104719135-104719136(+) m6A 5'UTR//CDS       24981863//26404942//27773535 chr12:104720175-104720176(+) m6A CDS       24981863//26404942//27773535//22575960 chr12:104721322-104721323(+) m6A CDS       24981863//26404942//27773535//22575960 chr12:104727964-104727965(+) m6A exon//intron       26404942 chr12:104728105-104728106(+) m6A CDS//exon       26404942 chr12:104732932-104732933(+) Y CDS//exon       26075521 chr12:104732996-104732997(+) m6A CDS//exon       26404942 chr12:104733016-104733017(+) m6A CDS//exon       26404942 chr12:104739926-104739927(+) m6A 3'UTR//intron       24284625//22575960 chr12:104742225-104742226(+) m6A 3'UTR//exon       24284625//26404942//22575960 chr12:104742232-104742233(+) m6A 3'UTR//exon       24284625//26404942//22575960 chr12:104742401-104742402(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr12:104742486-104742487(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr12:104742735-104742736(+) m6A 3'UTR       26404942//22575960 chr12:104742756-104742757(+) m6A 3'UTR       26404942//22575960 chr12:104742807-104742808(+) m6A 3'UTR       26404942 chr12:104742973-104742974(+) m6A 3'UTR       26404942 chr12:104742997-104742998(+) m6A 3'UTR       26404942 chr12:104743069-104743070(+) m6A 3'UTR       26404942 chr12:104743155-104743156(+) m6A 3'UTR       26404942 chr12:104743264-104743265(+) m6A 3'UTR       26404942 chr12:104743829-104743830(+) m6A 3'UTR       26404942//27773535 chr12:104743930-104743931(+) m6A 3'UTR       27773535 chr12:104743971-104743972(+) m6A 3'UTR       27773535 chr12:104744019-104744020(+) m6A 3'UTR       27773535 chr12:104744024-104744025(+) m6A 3'UTR       27773535 chr12:104744034-104744035(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TXNRD1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-5p
Interactor2: TXNRD1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.