Basic Information:

  VIRBase ID:  

VHID00383852

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:  MIMAT0003719          COX6B1:  NM_001863     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-5p	COX6B1
miRBase Accession/Entrez ID	MIMAT0003719	1340
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	COX6B//COXG//COXVIb1//MC4DN7

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	COX6B1	chr19:36144791(+) A-I      intronic chr19:36144849(+) A-I      intronic chr19:36145255(+) A-I      intronic chr19:36142995(+) A-I      intronic chr19:36141051(+) A-I      intronic chr19:36141140(+) A-I      intronic chr19:36141179(+) A-I      intronic chr19:36141466(+) A-I      intronic chr19:36141586(+) A-I      intronic chr19:36142988(+) A-I      intronic chr19:36144062(+) A-I      intronic chr19:36144600(+) A-I      intronic chr19:36141381(+) A-I      intronic chr19:36145351(+) A-I      intronic chr19:36144009(+) A-I      intronic chr19:36145355(+) A-I      intronic chr19:36144127(+) A-I      intronic chr19:36145170(+) A-I      intronic chr19:36145169(+) A-I      intronic chr19:36144137(+) A-I      intronic chr19:36142652(+) A-I      intronic chr19:36141463(+) A-I      intronic chr19:36141359(+) A-I      intronic chr19:36144074(+) A-I      intronic chr19:36144803(+) A-I      intronic chr19:36141045(+) A-I      intronic chr19:36142495(+) A-I      intronic chr19:36141489(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	COX6B1	chr19:36139186-36139187(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr19:36139573-36139574(+) m6A 5'UTR//intron       24284625//24981863//27773535 chr19:36139605-36139606(+) m6A 5'UTR//intron       24284625//27773535 chr19:36142155-36142156(+) m6A CDS       24981863//26404942 chr19:36142163-36142164(+) m6A CDS       24981863//26404942 chr19:36142176-36142177(+) m6A CDS       24981863//26404942 chr19:36142184-36142185(+) m6A CDS       24981863//26404942 chr19:36142218-36142219(+) m6A CDS       24981863//26404942//27773535 chr19:36142223-36142224(+) m6A CDS       24981863//26404942//27773535 chr19:36142230-36142231(+) m6A CDS       24981863//26404942//27773535 chr19:36142242-36142243(+) m6A CDS       24981863//26404942//27773535//22575960 chr19:36149502-36149503(+) m6A CDS       27773535//22575960 chr19:36149549-36149550(+) m6A 3'UTR       27773535//22575960 chr19:36149607-36149608(+) m6A 3'UTR       24284625//27773535 chr19:36149667-36149668(+) m6A 3'UTR       24284625//27773535 chr19:36149685-36149686(+) m6A 3'UTR       24284625//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	COX6B1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-5p
Interactor2: COX6B1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.