Basic Information:

  VIRBase ID:  

VHID00383815

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART20-5p:  MIMAT0003719          CENPB:  NM_001810     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART20-5p	CENPB
miRBase Accession/Entrez ID	MIMAT0003719	1059
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CENPB	chr20:3764933-3764934(-) m6A 3'UTR       24284625//24981863//26404942//27773536//22575960//22608085 chr20:3765028-3765029(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//22575960//22608085 chr20:3765083-3765084(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr20:3765271-3765272(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr20:3765321-3765322(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr20:3765342-3765343(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr20:3765376-3765377(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr20:3765405-3765406(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr20:3765591-3765592(-) Cm CDS       - chr20:3765592-3765593(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr20:3765604-3765605(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr20:3765706-3765707(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr20:3765754-3765755(-) m1A CDS       26863196//26863410 chr20:3765889-3765890(-) m1A CDS       26863196//26863410 chr20:3765994-3765995(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr20:3766216-3766217(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr20:3766285-3766286(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr20:3766541-3766542(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085 chr20:3766759-3766760(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085 chr20:3766928-3766929(-) m6A CDS       24284625//27371828//27773536//22575960//22608085 chr20:3766987-3766988(-) m6A CDS       24284625//26404942//27773535//27371828//27773536//22575960 chr20:3767056-3767057(-) m6A CDS       24284625//24209618//26404942//27773535//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CENPB	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART20-5p
Interactor2: CENPB

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.