Basic Information:

  VIRBase ID:  

VHID00380694

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-3p:  MIMAT0003718          GSKIP:  NM_001271905     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART19-3p	GSKIP
miRBase Accession/Entrez ID	MIMAT0003718	51527
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf129//HSPC210

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GSKIP	chr14:96829823-96829824(+) m1A 5'UTR       26863410 chr14:96829884-96829885(+) m1A 5'UTR//exon       26863196//26863410 chr14:96830369-96830370(+) m6A 5'UTR//intron       25456834 chr14:96830443-96830444(+) m6A 5'UTR//intron       24209618 chr14:96830456-96830457(+) m6A 5'UTR//intron       24209618 chr14:96830759-96830760(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830765-96830766(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830778-96830779(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830899-96830900(+) m6A 5'UTR//intron       24284625//22608085 chr14:96830940-96830941(+) m6A 5'UTR//intron       - chr14:96830996-96830997(+) m6A 5'UTR//intron       24981863 chr14:96831097-96831098(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr14:96831119-96831120(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr14:96831204-96831205(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr14:96831311-96831312(+) m6A 5'UTR//intron       22608085 chr14:96831324-96831325(+) m6A 5'UTR//intron       22608085 chr14:96845319-96845320(+) m6A 5'UTR//intron       24981863 chr14:96845346-96845347(+) m6A 5'UTR//intron       24981863 chr14:96848590-96848591(+) m6A CDS       25456834//24981863//22608085 chr14:96848665-96848666(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr14:96848678-96848679(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr14:96848791-96848792(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr14:96848804-96848805(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr14:96848820-96848821(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851050-96851051(+) Y intron       25219674 chr14:96851901-96851902(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851916-96851917(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851987-96851988(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chr14:96852011-96852012(+) m6A CDS       24284625//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART19-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438
	GSKIP	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART19-3p
Interactor2: GSKIP

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.