Basic Information:

  VIRBase ID:  

VHID00379808

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-3p:  MIMAT0003718          PAPOLA:  NM_001363665     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART19-3p	PAPOLA
miRBase Accession/Entrez ID	MIMAT0003718	10914
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAP//PAP-alpha

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PAPOLA	chr14:97028491(+) A-I      intronic chr14:97028503(+) A-I      intronic chr14:96995872(+) A-I      intronic chr14:96980717(+) A-I      intronic chr14:96992809(+) A-I      intronic chr14:96995902(+) A-I      intronic chr14:96988817(+) A-I      intronic chr14:96996793(+) A-I      intronic chr14:96991941(+) A-I      intronic chr14:96991967(+) A-I      intronic chr14:97028490(+) A-I      intronic chr14:96985229(+) A-I      intronic chr14:96972438(+) A-I      intronic chr14:96991010(+) A-I      intronic chr14:97019979(+) A-I      intronic chr14:96970875(+) A-I      intronic chr14:97000097(+) A-I      intronic chr14:97019600(+) A-I      intronic chr14:96996008(+) A-I      intronic chr14:97015792(+) A-I      intronic chr14:96975402(+) A-I      intronic chr14:96996911(+) A-I      intronic chr14:96996000(+) A-I      intronic chr14:97019697(+) A-I      intronic chr14:96970917(+) A-I      intronic chr14:97019727(+) A-I      intronic chr14:96995912(+) A-I      intronic chr14:96970784(+) A-I      intronic chr14:97019588(+) A-I      intronic chr14:96996759(+) A-I      intronic chr14:96996824(+) A-I      intronic chr14:96995980(+) A-I      intronic chr14:96990907(+) A-I      intronic chr14:96997419(+) A-I      intronic chr14:96972341(+) A-I      intronic chr14:97020058(+) A-I      intronic chr14:96985351(+) A-I      intronic chr14:96988036(+) A-I      intronic chr14:96988368(+) A-I      intronic chr14:96988860(+) A-I      intronic chr14:96988902(+) A-I      intronic chr14:96988942(+) A-I      intronic chr14:96990084(+) A-I      intronic chr14:96990090(+) A-I      intronic chr14:96990160(+) A-I      intronic chr14:96990201(+) A-I      intronic chr14:97019805(+) A-I      intronic chr14:96990212(+) A-I      intronic chr14:96990225(+) A-I      intronic chr14:96990880(+) A-I      intronic chr14:96990884(+) A-I      intronic chr14:96991984(+) A-I      intronic chr14:96994987(+) A-I      intronic chr14:96996836(+) A-I      intronic chr14:96995782(+) A-I      intronic chr14:96995804(+) A-I      intronic chr14:96990028(+) A-I      intronic chr14:96995805(+) A-I      intronic chr14:96995871(+) A-I      intronic chr14:96988084(+) A-I      intronic chr14:96985160(+) A-I      intronic chr14:96995896(+) A-I      intronic chr14:96995904(+) A-I      intronic chr14:96997395(+) A-I      intronic chr14:96995944(+) A-I      intronic chr14:96995965(+) A-I      intronic chr14:97019906(+) A-I      intronic chr14:96997245(+) A-I      intronic chr14:96987961(+) A-I      intronic chr14:96997456(+) A-I      intronic chr14:96988916(+) A-I      intronic chr14:96990224(+) A-I      intronic chr14:96996962(+) A-I      intronic chr14:96996823(+) A-I      intronic chr14:96995988(+) A-I      intronic chr14:96996046(+) A-I      intronic chr14:96997469(+) A-I      intronic chr14:96997480(+) A-I      intronic chr14:97019568(+) A-I      intronic chr14:96977716(+) A-I      intronic chr14:96997488(+) A-I      intronic chr14:97019696(+) A-I      intronic chr14:96997491(+) A-I      intronic chr14:96997515(+) A-I      intronic chr14:96995938(+) A-I      intronic chr14:96997524(+) A-I      intronic chr14:96997549(+) A-I      intronic chr14:96997711(+) A-I      intronic chr14:96997253(+) A-I      intronic chr14:96988050(+) A-I      intronic chr14:97019793(+) A-I      intronic chr14:96990970(+) A-I      intronic chr14:97019668(+) A-I      intronic chr14:96985139(+) A-I      intronic chr14:97019651(+) A-I      intronic chr14:96995916(+) A-I      intronic chr14:96997182(+) A-I      intronic chr14:96970918(+) A-I      intronic chr14:96997658(+) A-I      intronic chr14:96996009(+) A-I      intronic chr14:97016308(+) A-I      intronic chr14:96972380(+) A-I      intronic chr14:97019512(+) A-I      intronic chr14:96979561(+) A-I      intronic chr14:96991961(+) A-I      intronic chr14:96987957(+) A-I      intronic chr14:96972421(+) A-I      intronic chr14:97019601(+) A-I      intronic chr14:96972267(+) A-I      intronic chr14:96985339(+) A-I      intronic chr14:96997545(+) A-I      intronic chr14:96990027(+) A-I      intronic chr14:97019737(+) A-I      intronic chr14:96997694(+) A-I      intronic chr14:97019434(+) A-I      intronic chr14:96991968(+) A-I      intronic chr14:96996592(+) A-I      intronic chr14:96990070(+) A-I      intronic chr14:96995796(+) A-I      intronic chr14:96997326(+) A-I      intronic chr14:96997252(+) A-I      intronic chr14:97019813(+) A-I      intronic chr14:96996864(+) A-I      intronic chr14:96970958(+) A-I      intronic chr14:97023649(+) A-I      intronic chr14:96990071(+) A-I      intronic chr14:96996909(+) A-I      intronic chr14:96996854(+) A-I      intronic chr14:96995899(+) A-I      intronic chr14:97019654(+) A-I      intronic chr14:96985517(+) A-I      intronic chr14:96992787(+) A-I      intronic chr14:97019483(+) A-I      intronic chr14:96988197(+) A-I      intronic chr14:96988044(+) A-I      intronic chr14:97016364(+) A-I      intronic chr14:97019640(+) A-I      intronic chr14:96988956(+) A-I      intronic chr14:97019630(+) A-I      intronic chr14:97030563(+) A-I      intronic chr14:97019517(+) A-I      intronic chr14:96995952(+) A-I      intronic chr14:97019900(+) A-I      intronic chr14:96995857(+) A-I      intronic chr14:96995856(+) A-I      intronic chr14:97020083(+) A-I      intronic chr14:96997478(+) A-I      intronic chr14:96997390(+) A-I      intronic chr14:96985376(+) A-I      intronic chr14:97016288(+) A-I      intronic chr14:96985138(+) A-I      intronic chr14:97019594(+) A-I      intronic chr14:96997650(+) A-I      intronic chr14:97019950(+) A-I      intronic chr14:96997522(+) A-I      intronic chr14:97019903(+) A-I      intronic chr14:97019469(+) A-I      intronic chr14:96989016(+) A-I      intronic chr14:96996851(+) A-I      intronic chr14:96985162(+) A-I      intronic chr14:96995897(+) A-I      intronic chr14:97000021(+) A-I      intronic chr14:96995882(+) A-I      intronic chr14:96997468(+) A-I      intronic chr14:96970762(+) A-I      intronic chr14:96970963(+) A-I      intronic chr14:96997521(+) A-I      intronic chr14:97030643(+) A-I      intronic chr14:97016235(+) A-I      intronic chr14:96997308(+) A-I      intronic chr14:96988180(+) A-I      intronic chr14:97019509(+) A-I      intronic chr14:96978635(+) A-I      intronic chr14:97028497(+) A-I      intronic chr14:97019522(+) A-I      intronic chr14:96991946(+) A-I      intronic chr14:97019741(+) A-I      intronic chr14:96997600(+) A-I      intronic chr14:96997609(+) A-I      intronic chr14:96984275(+) A-I      intronic chr14:96972415(+) A-I      intronic chr14:96997191(+) A-I      intronic chr14:97016441(+) A-I      intronic chr14:96997251(+) A-I      intronic chr14:97019649(+) A-I      intronic chr14:96997599(+) A-I      intronic chr14:97019595(+) A-I      intronic chr14:97019750(+) A-I      intronic chr14:96982895(+) A-I      intronic chr14:96972358(+) A-I      intronic chr14:96968767(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PAPOLA	chr14:96968767(+) A-I exon 5'UTR    19478186 chr14:96970918(+) A-I intron -    15258596 chr14:96970958(+) A-I intron -    15258596 chr14:96970963(+) A-I intron -    15258596 chr14:97019524(+) A-I intron -    15258596 chr14:97019601(+) A-I intron -    15258596   //22327324 chr14:97019654(+) A-I intron -    15258596 chr14:97019668(+) A-I intron -    15258596 chr14:97019741(+) A-I intron -    21960545   //22327324 chr14:96992787(+) A-I intron -    21960545 chr14:96996773(+) A-I intron -    21960545 chr14:97030643(+) A-I intron -    21960545 chr14:97019601(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PAPOLA	chr14:96967874-96967875(+) m6A exon       24981863//22608085 chr14:96968815-96968816(+) m6A 5'UTR//CDS//exon//intron       24209618//25456834//24981863//26404942//22575960//22608085 chr14:96969205-96969206(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr14:96970949-96970950(+) m6A exon//intron       - chr14:96971027-96971028(+) m6A exon//intron       26404942 chr14:96986419-96986420(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:96986482-96986483(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:96986505-96986506(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:97022188-97022189(+) m6A 3'UTR//CDS//exon       27773535 chr14:97022537-97022538(+) m6A 3'UTR//CDS       27773535 chr14:97022613-97022614(+) m6A 3'UTR//CDS       27773535 chr14:97022699-97022700(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97022735-97022736(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97022741-97022742(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97026828-97026829(+) m6A exon//intron       24981863//27773535 chr14:97026844-97026845(+) m6A exon//intron       24981863//27773535 chr14:97026981-97026982(+) m6A exon//intron       24284625 chr14:97026991-97026992(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97027026-97027027(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97027036-97027037(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97028798-97028799(+) m6A exon//intron       24284625 chr14:97029157-97029158(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//22608085 chr14:97029173-97029174(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr14:97029194-97029195(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr14:97029203-97029204(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr14:97031294-97031295(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:97031307-97031308(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:97031368-97031369(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr14:97031389-97031390(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031409-97031410(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031472-97031473(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031477-97031478(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031637-97031638(+) m6A 3'UTR       24284625//24981863//22608085 chr14:97032261-97032262(+) m6A 3'UTR       27773535 chr14:97032297-97032298(+) m6A 3'UTR       27773535 chr14:97033298-97033299(+) m6A 3'UTR       27773535 chr14:97033397-97033398(+) m6A 3'UTR       27773535 chr14:97033423-97033424(+) m6A 3'UTR       27773535 chr14:97033439-97033440(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART19-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438
	PAPOLA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART19-3p
Interactor2: PAPOLA

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.