Basic Information:

  VIRBase ID:  

VHID00378729

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-3p:  MIMAT0003718          RO60:  NM_001331020     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART19-3p	RO60
miRBase Accession/Entrez ID	MIMAT0003718	6738
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	RORNP//SSA2//TROVE2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RO60	chr1:193037602(+) A-I      intronic chr1:193030962(+) A-I      intronic chr1:193041314(+) A-I      intronic chr1:193041299(+) A-I      intronic chr1:193049200(+) A-I      intronic chr1:193044159(+) A-I      intronic chr1:193041308(+) A-I      intronic chr1:193049047(+) A-I      intronic chr1:193031077(+) A-I      intronic chr1:193047731(+) A-I      intronic chr1:193049206(+) A-I      intronic chr1:193049001(+) A-I      intronic chr1:193031053(+) A-I      intronic chr1:193051916(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART19-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438
	RO60	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART19-3p
Interactor2: RO60

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.