Basic Information:

  VIRBase ID:  

VHID00377696

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-3p:  MIMAT0003718          FNTB:  NM_002028     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART19-3p	FNTB
miRBase Accession/Entrez ID	MIMAT0003718	2342
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	FPTB

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FNTB	chr14:65497652(+) A-I      intronic chr14:65506757(+) A-I      intronic chr14:65506723(+) A-I      intronic chr14:65506721(+) A-I      intronic chr14:65492326(+) A-I      intronic chr14:65492331(+) A-I      intronic chr14:65492332(+) A-I      intronic chr14:65491025(+) A-I      intronic chr14:65461266(+) A-I      intronic chr14:65489324(+) A-I      intronic chr14:65489319(+) A-I      intronic chr14:65489305(+) A-I      intronic chr14:65485363(+) A-I      intronic chr14:65488444(+) A-I      intronic chr14:65489359(+) A-I      intronic chr14:65489881(+) A-I      intronic chr14:65490673(+) A-I      intronic chr14:65490709(+) A-I      intronic chr14:65497242(+) A-I      intronic chr14:65492372(+) A-I      intronic chr14:65506700(+) A-I      intronic chr14:65506711(+) A-I      intronic chr14:65489871(+) A-I      intronic chr14:65489876(+) A-I      intronic chr14:65489877(+) A-I      intronic chr14:65489906(+) A-I      intronic chr14:65489949(+) A-I      intronic chr14:65489977(+) A-I      intronic chr14:65490604(+) A-I      intronic chr14:65490642(+) A-I      intronic chr14:65490659(+) A-I      intronic chr14:65490668(+) A-I      intronic chr14:65490699(+) A-I      intronic chr14:65490716(+) A-I      intronic chr14:65490729(+) A-I      intronic chr14:65490740(+) A-I      intronic chr14:65490745(+) A-I      intronic chr14:65491571(+) A-I      intronic chr14:65491575(+) A-I      intronic chr14:65491576(+) A-I      intronic chr14:65491602(+) A-I      intronic chr14:65491611(+) A-I      intronic chr14:65431764(+) A-I      intronic chr14:65492259(+) A-I      intronic chr14:65492286(+) A-I      intronic chr14:65492356(+) A-I      intronic chr14:65492377(+) A-I      intronic chr14:65492380(+) A-I      intronic chr14:65492382(+) A-I      intronic chr14:65492413(+) A-I      intronic chr14:65492447(+) A-I      intronic chr14:65497216(+) A-I      intronic chr14:65497262(+) A-I      intronic chr14:65497275(+) A-I      intronic chr14:65497278(+) A-I      intronic chr14:65497313(+) A-I      intronic chr14:65497353(+) A-I      intronic chr14:65497367(+) A-I      intronic chr14:65497378(+) A-I      intronic chr14:65497441(+) A-I      intronic chr14:65497442(+) A-I      intronic chr14:65497600(+) A-I      intronic chr14:65497626(+) A-I      intronic chr14:65491534(+) A-I      intronic chr14:65497627(+) A-I      intronic chr14:65497651(+) A-I      intronic chr14:65497667(+) A-I      intronic chr14:65497692(+) A-I      intronic chr14:65497726(+) A-I      intronic chr14:65497762(+) A-I      intronic chr14:65497764(+) A-I      intronic chr14:65497788(+) A-I      intronic chr14:65498097(+) A-I      intronic chr14:65498136(+) A-I      intronic chr14:65498238(+) A-I      intronic chr14:65498296(+) A-I      intronic chr14:65498389(+) A-I      intronic chr14:65489856(+) A-I      intronic chr14:65483875(+) A-I      intronic chr14:65498448(+) A-I      intronic chr14:65498487(+) A-I      intronic chr14:65498488(+) A-I      intronic chr14:65498491(+) A-I      intronic chr14:65498560(+) A-I      intronic chr14:65498573(+) A-I      intronic chr14:65498621(+) A-I      intronic chr14:65502317(+) A-I      intronic chr14:65504757(+) A-I      intronic chr14:65487657(+) A-I      intronic chr14:65502348(+) A-I      intronic chr14:65502351(+) A-I      intronic chr14:65478091(+) A-I      intronic chr14:65503522(+) A-I      intronic chr14:65503558(+) A-I      intronic chr14:65504873(+) A-I      intronic chr14:65483702(+) A-I      intronic chr14:65504880(+) A-I      intronic chr14:65504926(+) A-I      intronic chr14:65504931(+) A-I      intronic chr14:65505008(+) A-I      intronic chr14:65505034(+) A-I      intronic chr14:65505049(+) A-I      intronic chr14:65505053(+) A-I      intronic chr14:65462940(+) A-I      intronic chr14:65458175(+) A-I      intronic chr14:65484938(+) A-I      intronic chr14:65471474(+) A-I      intronic chr14:65459356(+) A-I      intronic chr14:65459575(+) A-I      intronic chr14:65459834(+) A-I      intronic chr14:65477913(+) A-I      intronic chr14:65477969(+) A-I      intronic chr14:65512308(+) A-I      intronic chr14:65512317(+) A-I      intronic chr14:65512334(+) A-I      intronic chr14:65477982(+) A-I      intronic chr14:65477883(+) A-I      intronic chr14:65477996(+) A-I      intronic chr14:65477997(+) A-I      intronic chr14:65478040(+) A-I      intronic chr14:65481380(+) A-I      intronic chr14:65481428(+) A-I      intronic chr14:65481885(+) A-I      intronic chr14:65481385(+) A-I      intronic chr14:65481901(+) A-I      intronic chr14:65497193(+) A-I      intronic chr14:65482004(+) A-I      intronic chr14:65483664(+) A-I      intronic chr14:65483684(+) A-I      intronic chr14:65456059(+) A-I      intronic chr14:65459908(+) A-I      intronic chr14:65481452(+) A-I      intronic chr14:65431119(+) A-I      intronic chr14:65456035(+) A-I      intronic chr14:65504598(+) A-I      intronic chr14:65483830(+) A-I      intronic chr14:65483880(+) A-I      intronic chr14:65483884(+) A-I      intronic chr14:65483903(+) A-I      intronic chr14:65483914(+) A-I      intronic chr14:65492489(+) A-I      intronic chr14:65484522(+) A-I      intronic chr14:65484558(+) A-I      intronic chr14:65484601(+) A-I      intronic chr14:65484878(+) A-I      intronic chr14:65484909(+) A-I      intronic chr14:65485266(+) A-I      intronic chr14:65485313(+) A-I      intronic chr14:65485318(+) A-I      intronic chr14:65504597(+) A-I      intronic chr14:65485368(+) A-I      intronic chr14:65485381(+) A-I      intronic chr14:65485424(+) A-I      intronic chr14:65485429(+) A-I      intronic chr14:65459654(+) A-I      intronic chr14:65485430(+) A-I      intronic chr14:65485434(+) A-I      intronic chr14:65490612(+) A-I      intronic chr14:65485440(+) A-I      intronic chr14:65477944(+) A-I      intronic chr14:65485477(+) A-I      intronic chr14:65485573(+) A-I      intronic chr14:65485574(+) A-I      intronic chr14:65485614(+) A-I      intronic chr14:65485681(+) A-I      intronic chr14:65518720(+) A-I      intronic chr14:65481982(+) A-I      intronic chr14:65485685(+) A-I      intronic chr14:65485686(+) A-I      intronic chr14:65485717(+) A-I      intronic chr14:65485882(+) A-I      intronic chr14:65485901(+) A-I      intronic chr14:65485950(+) A-I      intronic chr14:65486021(+) A-I      intronic chr14:65486049(+) A-I      intronic chr14:65481995(+) A-I      intronic chr14:65486085(+) A-I      intronic chr14:65504874(+) A-I      intronic chr14:65486094(+) A-I      intronic chr14:65486101(+) A-I      intronic chr14:65486190(+) A-I      intronic chr14:65497310(+) A-I      intronic chr14:65487051(+) A-I      intronic chr14:65487065(+) A-I      intronic chr14:65422872(+) A-I      intronic chr14:65481946(+) A-I      intronic chr14:65487083(+) A-I      intronic chr14:65487092(+) A-I      intronic chr14:65487093(+) A-I      intronic chr14:65487205(+) A-I      intronic chr14:65458211(+) A-I      intronic chr14:65487208(+) A-I      intronic chr14:65487309(+) A-I      intronic chr14:65487317(+) A-I      intronic chr14:65487426(+) A-I      intronic chr14:65487428(+) A-I      intronic chr14:65487511(+) A-I      intronic chr14:65481277(+) A-I      intronic chr14:65487567(+) A-I      intronic chr14:65456162(+) A-I      intronic chr14:65487576(+) A-I      intronic chr14:65488464(+) A-I      intronic chr14:65488503(+) A-I      intronic chr14:65459666(+) A-I      intronic chr14:65515426(+) A-I      intronic chr14:65488529(+) A-I      intronic chr14:65488530(+) A-I      intronic chr14:65497339(+) A-I      intronic chr14:65488584(+) A-I      intronic chr14:65488599(+) A-I      intronic chr14:65515321(+) A-I      intronic chr14:65488625(+) A-I      intronic chr14:65488626(+) A-I      intronic chr14:65489272(+) A-I      intronic chr14:65489274(+) A-I      intronic chr14:65515339(+) A-I      intronic chr14:65489295(+) A-I      intronic chr14:65489320(+) A-I      intronic chr14:65515413(+) A-I      intronic chr14:65489845(+) A-I      intronic chr14:65484509(+) A-I      intronic chr14:65483843(+) A-I      intronic chr14:65431478(+) A-I      intronic chr14:65503055(+) A-I      intronic chr14:65484526(+) A-I      intronic chr14:65459975(+) A-I      intronic chr14:65498564(+) A-I      intronic chr14:65428771(+) A-I      intronic chr14:65481425(+) A-I      intronic chr14:65484417(+) A-I      intronic chr14:65526656(+) A-I      intronic chr14:65484513(+) A-I      intronic chr14:65456051(+) A-I      intronic chr14:65505315(+) A-I      intronic chr14:65431797(+) A-I      intronic chr14:65504005(+) A-I      intronic chr14:65481350(+) A-I      intronic chr14:65506828(+) A-I      intronic chr14:65505316(+) A-I      intronic chr14:65456183(+) A-I      intronic chr14:65431717(+) A-I      intronic chr14:65505289(+) A-I      intronic chr14:65503576(+) A-I      intronic chr14:65459407(+) A-I      intronic chr14:65481411(+) A-I      intronic chr14:65489799(+) A-I      intronic chr14:65488547(+) A-I      intronic chr14:65456041(+) A-I      intronic chr14:65483824(+) A-I      intronic chr14:65503088(+) A-I      intronic chr14:65490637(+) A-I      intronic chr14:65459738(+) A-I      intronic chr14:65484798(+) A-I      intronic chr14:65489827(+) A-I      intronic chr14:65498519(+) A-I      intronic chr14:65487589(+) A-I      intronic chr14:65492386(+) A-I      intronic chr14:65423869(+) A-I      intronic chr14:65526652(+) A-I      intronic chr14:65458322(+) A-I      intronic chr14:65459744(+) A-I      intronic chr14:65481962(+) A-I      intronic chr14:65481348(+) A-I      intronic chr14:65468053(+) A-I      intronic chr14:65428882(+) A-I      intronic chr14:65489287(+) A-I      intronic chr14:65468001(+) A-I      intronic chr14:65497740(+) A-I      intronic chr14:65468121(+) A-I      intronic chr14:65456011(+) A-I      intronic chr14:65490563(+) A-I      intronic chr14:65485319(+) A-I      intronic chr14:65429119(+) A-I      intronic chr14:65468063(+) A-I      intronic chr14:65488586(+) A-I      intronic chr14:65490545(+) A-I      intronic chr14:65456012(+) A-I      intronic chr14:65468128(+) A-I      intronic chr14:65484478(+) A-I      intronic chr14:65491520(+) A-I      intronic chr14:65484512(+) A-I      intronic chr14:65481514(+) A-I      intronic chr14:65471481(+) A-I      intronic chr14:65481276(+) A-I      intronic chr14:65423797(+) A-I      intronic chr14:65481947(+) A-I      intronic chr14:65481389(+) A-I      intronic chr14:65504697(+) A-I      intronic chr14:65471403(+) A-I      intronic chr14:65481960(+) A-I      intronic chr14:65491572(+) A-I      intronic chr14:65489275(+) A-I      intronic chr14:65469290(+) A-I      intronic chr14:65422979(+) A-I      intronic chr14:65483710(+) A-I      intronic chr14:65497255(+) A-I      intronic chr14:65459870(+) A-I      intronic chr14:65498596(+) A-I      intronic chr14:65458228(+) A-I      intronic chr14:65490572(+) A-I      intronic chr14:65484517(+) A-I      intronic chr14:65489894(+) A-I      intronic chr14:65477945(+) A-I      intronic chr14:65471564(+) A-I      intronic chr14:65462670(+) A-I      intronic chr14:65481268(+) A-I      intronic chr14:65483740(+) A-I      intronic chr14:65484594(+) A-I      intronic chr14:65490012(+) A-I      intronic chr14:65483741(+) A-I      intronic chr14:65502327(+) A-I      intronic chr14:65487632(+) A-I      intronic chr14:65497665(+) A-I      intronic chr14:65498518(+) A-I      intronic chr14:65462688(+) A-I      intronic chr14:65489812(+) A-I      intronic chr14:65483758(+) A-I      intronic chr14:65488632(+) A-I      intronic chr14:65497723(+) A-I      intronic chr14:65456031(+) A-I      intronic chr14:65503084(+) A-I      intronic chr14:65504745(+) A-I      intronic chr14:65488481(+) A-I      intronic chr14:65504591(+) A-I      intronic chr14:65431767(+) A-I      intronic chr14:65487519(+) A-I      intronic chr14:65490564(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FNTB	chr14:65455282(+) A-I intron -    15342557   //15258596 chr14:65455287(+) A-I intron -    15342557   //15258596 chr14:65455292(+) A-I intron -    15342557   //15258596 chr14:65455302(+) A-I intron -    15342557   //15258596 chr14:65455332(+) A-I intron -    15342557   //15258596 chr14:65455351(+) A-I intron -    15342557   //15258596 chr14:65455903(+) A-I intron -    15342557 chr14:65455904(+) A-I intron -    15342557 chr14:65455912(+) A-I intron -    15342557 chr14:65455950(+) A-I intron -    15342557 chr14:65455971(+) A-I intron -    15342557

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FNTB	chr14:65453794-65453795(+) m6A CDS//exon       - chr14:65453811-65453812(+) m6A CDS//exon       - chr14:65454104-65454105(+) m6A exon//intron       - chr14:65454128-65454129(+) m6A exon//intron       - chr14:65527927-65527928(+) m6A CDS//exon       24209618 chr14:65527932-65527933(+) m6A CDS//exon       24209618 chr14:65528003-65528004(+) m6A CDS//exon       24209618//24981863//22608085 chr14:65528033-65528034(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr14:65528077-65528078(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr14:65528170-65528171(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528175-65528176(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528198-65528199(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528239-65528240(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528276-65528277(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528416-65528417(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr14:65528500-65528501(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr14:65528634-65528635(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65528687-65528688(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65528718-65528719(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65528727-65528728(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65528776-65528777(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr14:65528828-65528829(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr14:65528902-65528903(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr14:65528926-65528927(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART19-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438
	FNTB	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART19-3p
Interactor2: FNTB

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.