Basic Information:

  VIRBase ID:  

VHID00376782

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          PDE12:  NM_001322177     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	PDE12
miRBase Accession/Entrez ID	MIMAT0003717	201626
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	2'-PDE//2-PDE

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDE12	chr3:57544801(+) A-I      intronic chr3:57546192(+) A-I      3'UTR chr3:57546182(+) A-I      3'UTR chr3:57546153(+) A-I      3'UTR chr3:57546152(+) A-I      3'UTR chr3:57544357(+) A-I      intronic chr3:57544271(+) A-I      intronic chr3:57544889(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDE12	chr3:57544357(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDE12	chr3:57542193-57542194(+) m6A CDS       24284625 chr3:57542243-57542244(+) m6A CDS       24284625 chr3:57542290-57542291(+) m6A CDS       24284625 chr3:57542603-57542604(+) m6A CDS       24284625//22575960 chr3:57542651-57542652(+) m6A CDS       24284625//22575960//22608085 chr3:57542781-57542782(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr3:57542787-57542788(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:57543019-57543020(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543033-57543034(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543103-57543104(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543119-57543120(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543344-57543345(+) m6A CDS       24284625//24981863//26404942//22608085 chr3:57543356-57543357(+) m6A CDS       24284625//24981863//26404942//22608085 chr3:57545061-57545062(+) m6A CDS       24284625//24981863//22608085 chr3:57545147-57545148(+) m6A 3'UTR//intron       24284625//22608085 chr3:57545207-57545208(+) m6A 3'UTR//intron       24284625//22608085 chr3:57545244-57545245(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr3:57545337-57545338(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr3:57545387-57545388(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr3:57545459-57545460(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085 chr3:57545538-57545539(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr3:57545619-57545620(+) m6A 3'UTR//CDS       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PDE12	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: PDE12

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.