Basic Information:

  VIRBase ID:  

VHID00376663

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          MIPOL1:  NM_001388070     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	MIPOL1
miRBase Accession/Entrez ID	MIMAT0003717	145282
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCDC193

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MIPOL1	chr14:37757754(+) A-I      intronic chr14:38000869(+) A-I      intronic chr14:38000856(+) A-I      intronic chr14:37990758(+) A-I      intronic chr14:38001832(+) A-I      intronic chr14:38001836(+) A-I      intronic chr14:38001867(+) A-I      intronic chr14:38001894(+) A-I      intronic chr14:37757925(+) A-I      intronic chr14:37847297(+) A-I      intronic chr14:38005129(+) A-I      intronic chr14:37846668(+) A-I      intronic chr14:38000898(+) A-I      intronic chr14:37842335(+) A-I      intronic chr14:38000911(+) A-I      intronic chr14:37756549(+) A-I      intronic chr14:37752329(+) A-I      intronic chr14:37754897(+) A-I      intronic chr14:38000889(+) A-I      intronic chr14:38000882(+) A-I      intronic chr14:38000866(+) A-I      intronic chr14:37754999(+) A-I      intronic chr14:37754871(+) A-I      intronic chr14:37751899(+) A-I      intronic chr14:37720501(+) A-I      intronic chr14:37841910(+) A-I      intronic chr14:37809660(+) A-I      intronic chr14:37757747(+) A-I      intronic chr14:37811407(+) A-I      intronic chr14:37815279(+) A-I      intronic chr14:37757108(+) A-I      intronic chr14:37757942(+) A-I      intronic chr14:37756642(+) A-I      intronic chr14:37815280(+) A-I      intronic chr14:37902395(+) A-I      intronic chr14:37757875(+) A-I      intronic chr14:37877196(+) A-I      intronic chr14:37815306(+) A-I      intronic chr14:37860742(+) A-I      intronic chr14:37877079(+) A-I      intronic chr14:37815285(+) A-I      intronic chr14:37877086(+) A-I      intronic chr14:37991097(+) A-I      intronic chr14:37897609(+) A-I      intronic chr14:37759450(+) A-I      intronic chr14:37785940(+) A-I      intronic chr14:37785926(+) A-I      intronic chr14:37897610(+) A-I      intronic chr14:37993842(+) A-I      intronic chr14:37859167(+) A-I      intronic chr14:37993866(+) A-I      intronic chr14:37705156(+) A-I      intronic chr14:37993873(+) A-I      intronic chr14:37785927(+) A-I      intronic chr14:37859281(+) A-I      intronic chr14:37757740(+) A-I      intronic chr14:37751513(+) A-I      intronic chr14:37757043(+) A-I      intronic chr14:37755008(+) A-I      intronic chr14:37751820(+) A-I      intronic chr14:37756488(+) A-I      intronic chr14:37877147(+) A-I      intronic chr14:38012574(+) A-I      intronic chr14:37690169(+) A-I      intronic chr14:37757780(+) A-I      intronic chr14:37806035(+) A-I      intronic chr14:37755004(+) A-I      intronic chr14:37757486(+) A-I      intronic chr14:37757762(+) A-I      intronic chr14:37755001(+) A-I      intronic chr14:37811658(+) A-I      intronic chr14:37688782(+) A-I      5'UTR chr14:37750759(+) A-I      intronic chr14:37757886(+) A-I      intronic chr14:37860740(+) A-I      intronic chr14:37751898(+) A-I      intronic chr14:37698035(+) A-I      intronic chr14:37754901(+) A-I      intronic chr14:37811705(+) A-I      intronic chr14:37695898(+) A-I      intronic chr14:38000910(+) A-I      intronic chr14:38001884(+) A-I      intronic chr14:37759495(+) A-I      intronic chr14:37751722(+) A-I      intronic chr14:38000505(+) A-I      intronic chr14:37757993(+) A-I      intronic chr14:37692435(+) A-I      intronic chr14:37755071(+) A-I      intronic chr14:37759452(+) A-I      intronic chr14:37786005(+) A-I      intronic chr14:37785373(+) A-I      intronic chr14:38001823(+) A-I      intronic chr14:37877108(+) A-I      intronic chr14:37786060(+) A-I      intronic chr14:37751676(+) A-I      intronic chr14:37811702(+) A-I      intronic chr14:37877313(+) A-I      intronic chr14:38000510(+) A-I      intronic chr14:37679106(+) A-I      intronic chr14:37759561(+) A-I      intronic chr14:37751503(+) A-I      intronic chr14:37811682(+) A-I      intronic chr14:37757807(+) A-I      intronic chr14:37785361(+) A-I      intronic chr14:37811667(+) A-I      intronic chr14:38000472(+) A-I      intronic chr14:37757863(+) A-I      intronic chr14:37679130(+) A-I      intronic chr14:37811703(+) A-I      intronic chr14:37809733(+) A-I      intronic chr14:37710665(+) A-I      intronic chr14:37757827(+) A-I      intronic chr14:37687992(+) A-I      intronic chr14:37756548(+) A-I      intronic chr14:37754877(+) A-I      intronic chr14:37757989(+) A-I      intronic chr14:37698023(+) A-I      intronic chr14:38000453(+) A-I      intronic chr14:37902399(+) A-I      intronic chr14:37757440(+) A-I      intronic chr14:38000458(+) A-I      intronic chr14:38012744(+) A-I      intronic chr14:37902367(+) A-I      intronic chr14:37701082(+) A-I      intronic chr14:37757844(+) A-I      intronic chr14:37912465(+) A-I      intronic chr14:37842338(+) A-I      intronic chr14:37998918(+) A-I      intronic chr14:37998834(+) A-I      intronic chr14:37754818(+) A-I      intronic chr14:37785349(+) A-I      intronic chr14:37708047(+) A-I      intronic chr14:37751741(+) A-I      intronic chr14:37809661(+) A-I      intronic chr14:37757823(+) A-I      intronic chr14:37758046(+) A-I      intronic chr14:37785371(+) A-I      intronic chr14:37842482(+) A-I      intronic chr14:37751711(+) A-I      intronic chr14:37754926(+) A-I      intronic chr14:37756679(+) A-I      intronic chr14:37801181(+) A-I      intronic chr14:37688019(+) A-I      intronic chr14:38001874(+) A-I      intronic chr14:37688834(+) A-I      5'UTR chr14:37688775(+) A-I      5'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MIPOL1	chr14:37736164-37736165(+) m6A 5'UTR//CDS//exon       24981863 chr14:37736171-37736172(+) m6A 5'UTR//CDS//exon       24981863 chr14:37777572-37777573(+) m6A CDS//exon//intron       24981863 chr14:37777581-37777582(+) m6A CDS//exon//intron       24981863 chr14:37777590-37777591(+) m6A CDS//exon//intron       24981863 chr14:37969195-37969196(+) m6A 3'UTR//CDS       24981863 chr14:37969204-37969205(+) m6A 3'UTR//CDS       24981863 chr14:37969238-37969239(+) m6A 3'UTR//CDS       24981863//22608085 chr14:37970757-37970758(+) m6A 3'UTR//intron       22608085 chr14:37970944-37970945(+) m6A 3'UTR//intron       25456834//22575960 chr14:37970953-37970954(+) m6A 3'UTR//intron       25456834//22575960 chr14:38015255-38015256(+) m6A 3'UTR//intron       22608085 chr14:38016149-38016150(+) m6A CDS       22608085 chr14:38016155-38016156(+) m6A CDS       22608085 chr14:38016164-38016165(+) m6A CDS       22608085 chr14:38016247-38016248(+) m6A 3'UTR       24981863//22608085 chr14:38016270-38016271(+) m6A 3'UTR       24981863//22608085 chr14:38016288-38016289(+) m6A 3'UTR       24981863//22608085 chr14:38016387-38016388(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MIPOL1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: MIPOL1

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.