Basic Information:

  VIRBase ID:  

VHID00376379

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9070

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          PCGF6:  NM_001011663     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	PCGF6
miRBase Accession/Entrez ID	MIMAT0003717	84108
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	MBLR//RNF134

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PCGF6	chr10:105066128(-) A-I      intronic chr10:105070628(-) A-I      intronic chr10:105066134(-) A-I      intronic chr10:105066106(-) A-I      intronic chr10:105066127(-) A-I      intronic chr10:105096429(-) A-I      intronic chr10:105099461(-) A-I      intronic chr10:105103397(-) A-I      intronic chr10:105103407(-) A-I      intronic chr10:105101952(-) A-I      intronic chr10:105065255(-) A-I      intronic chr10:105065295(-) A-I      intronic chr10:105065575(-) A-I      intronic chr10:105065952(-) A-I      intronic chr10:105066639(-) A-I      intronic chr10:105066644(-) A-I      intronic chr10:105102890(-) A-I      intronic chr10:105066761(-) A-I      intronic chr10:105071961(-) A-I      intronic chr10:105106430(-) A-I      intronic chr10:105106428(-) A-I      intronic chr10:105102935(-) A-I      intronic chr10:105103361(-) A-I      intronic chr10:105081791(-) A-I      intronic chr10:105071155(-) A-I      intronic chr10:105082422(-) A-I      intronic chr10:105103427(-) A-I      intronic chr10:105106417(-) A-I      intronic chr10:105084515(-) A-I      intronic chr10:105073239(-) A-I      intronic chr10:105104222(-) A-I      intronic chr10:105074527(-) A-I      intronic chr10:105065951(-) A-I      intronic chr10:105104230(-) A-I      intronic chr10:105083946(-) A-I      intronic chr10:105083942(-) A-I      intronic chr10:105087666(-) A-I      intronic chr10:105068294(-) A-I      intronic chr10:105067094(-) A-I      intronic chr10:105065207(-) A-I      intronic chr10:105082535(-) A-I      intronic chr10:105102058(-) A-I      intronic chr10:105070932(-) A-I      intronic chr10:105069875(-) A-I      intronic chr10:105070934(-) A-I      intronic chr10:105070984(-) A-I      intronic chr10:105068606(-) A-I      intronic chr10:105094902(-) A-I      intronic chr10:105092749(-) A-I      intronic chr10:105071171(-) A-I      intronic chr10:105070640(-) A-I      intronic chr10:105082236(-) A-I      intronic chr10:105071172(-) A-I      intronic chr10:105067758(-) A-I      intronic chr10:105105402(-) A-I      intronic chr10:105071178(-) A-I      intronic chr10:105069927(-) A-I      intronic chr10:105070598(-) A-I      intronic chr10:105071188(-) A-I      intronic chr10:105082162(-) A-I      intronic chr10:105071628(-) A-I      intronic chr10:105083488(-) A-I      intronic chr10:105071907(-) A-I      intronic chr10:105072002(-) A-I      intronic chr10:105072050(-) A-I      intronic chr10:105103538(-) A-I      intronic chr10:105088637(-) A-I      intronic chr10:105072631(-) A-I      intronic chr10:105085525(-) A-I      intronic chr10:105072655(-) A-I      intronic chr10:105074612(-) A-I      intronic chr10:105095667(-) A-I      intronic chr10:105096549(-) A-I      intronic chr10:105076956(-) A-I      intronic chr10:105095662(-) A-I      intronic chr10:105095661(-) A-I      intronic chr10:105095638(-) A-I      intronic chr10:105095580(-) A-I      intronic chr10:105095506(-) A-I      intronic chr10:105095078(-) A-I      intronic chr10:105095560(-) A-I      intronic chr10:105079087(-) A-I      intronic chr10:105095061(-) A-I      intronic chr10:105070738(-) A-I      intronic chr10:105079172(-) A-I      intronic chr10:105094919(-) A-I      intronic chr10:105094893(-) A-I      intronic chr10:105105463(-) A-I      intronic chr10:105097885(-) A-I      intronic chr10:105085186(-) A-I      intronic chr10:105077390(-) A-I      intronic chr10:105096550(-) A-I      intronic chr10:105096588(-) A-I      intronic chr10:105097468(-) A-I      intronic chr10:105073104(-) A-I      intronic chr10:105094845(-) A-I      intronic chr10:105102210(-) A-I      intronic chr10:105091717(-) A-I      intronic chr10:105073117(-) A-I      intronic chr10:105073118(-) A-I      intronic chr10:105098913(-) A-I      intronic chr10:105077321(-) A-I      intronic chr10:105078007(-) A-I      intronic chr10:105098927(-) A-I      intronic chr10:105081793(-) A-I      intronic chr10:105098928(-) A-I      intronic chr10:105104205(-) A-I      intronic chr10:105104599(-) A-I      intronic chr10:105098516(-) A-I      intronic chr10:105100601(-) A-I      intronic chr10:105099023(-) A-I      intronic chr10:105079180(-) A-I      intronic chr10:105091661(-) A-I      intronic chr10:105073119(-) A-I      intronic chr10:105079181(-) A-I      intronic chr10:105078034(-) A-I      intronic chr10:105095083(-) A-I      intronic chr10:105078078(-) A-I      intronic chr10:105079842(-) A-I      intronic chr10:105091658(-) A-I      intronic chr10:105078174(-) A-I      intronic chr10:105091193(-) A-I      intronic chr10:105099702(-) A-I      intronic chr10:105070928(-) A-I      intronic chr10:105079733(-) A-I      intronic chr10:105099739(-) A-I      intronic chr10:105070967(-) A-I      intronic chr10:105091185(-) A-I      intronic chr10:105091105(-) A-I      intronic chr10:105095891(-) A-I      intronic chr10:105083248(-) A-I      intronic chr10:105090610(-) A-I      intronic chr10:105090604(-) A-I      intronic chr10:105067112(-) A-I      intronic chr10:105099890(-) A-I      intronic chr10:105097922(-) A-I      intronic chr10:105073246(-) A-I      intronic chr10:105072090(-) A-I      intronic chr10:105088699(-) A-I      intronic chr10:105079753(-) A-I      intronic chr10:105083371(-) A-I      intronic chr10:105079836(-) A-I      intronic chr10:105083418(-) A-I      intronic chr10:105090600(-) A-I      intronic chr10:105070624(-) A-I      intronic chr10:105067448(-) A-I      intronic chr10:105090036(-) A-I      intronic chr10:105100651(-) A-I      intronic chr10:105080187(-) A-I      intronic chr10:105089957(-) A-I      intronic chr10:105077644(-) A-I      intronic chr10:105081357(-) A-I      intronic chr10:105101405(-) A-I      intronic chr10:105089846(-) A-I      intronic chr10:105089603(-) A-I      intronic chr10:105089423(-) A-I      intronic chr10:105089324(-) A-I      intronic chr10:105082213(-) A-I      intronic chr10:105089273(-) A-I      intronic chr10:105089264(-) A-I      intronic chr10:105095869(-) A-I      intronic chr10:105091117(-) A-I      intronic chr10:105080214(-) A-I      intronic chr10:105089078(-) A-I      intronic chr10:105086998(-) A-I      intronic chr10:105099425(-) A-I      intronic chr10:105088889(-) A-I      intronic chr10:105101443(-) A-I      intronic chr10:105101897(-) A-I      intronic chr10:105088774(-) A-I      intronic chr10:105067328(-) A-I      intronic chr10:105101906(-) A-I      intronic chr10:105104140(-) A-I      intronic chr10:105067346(-) A-I      intronic chr10:105102797(-) A-I      intronic chr10:105087669(-) A-I      intronic chr10:105086955(-) A-I      intronic chr10:105091714(-) A-I      intronic chr10:105085148(-) A-I      intronic chr10:105081345(-) A-I      intronic chr10:105081347(-) A-I      intronic chr10:105102814(-) A-I      intronic chr10:105107608(-) A-I      intronic chr10:105083146(-) A-I      intronic chr10:105081773(-) A-I      intronic chr10:105083246(-) A-I      intronic chr10:105081947(-) A-I      intronic chr10:105105475(-) A-I      intronic chr10:105106483(-) A-I      intronic chr10:105073139(-) A-I      intronic chr10:105078257(-) A-I      intronic chr10:105067111(-) A-I      intronic chr10:105102818(-) A-I      intronic chr10:105078169(-) A-I      intronic chr10:105102826(-) A-I      intronic chr10:105066712(-) A-I      intronic chr10:105085658(-) A-I      intronic chr10:105086942(-) A-I      intronic chr10:105085650(-) A-I      intronic chr10:105082375(-) A-I      intronic chr10:105065010(-) A-I      intronic chr10:105078258(-) A-I      intronic chr10:105095947(-) A-I      intronic chr10:105085143(-) A-I      intronic chr10:105103418(-) A-I      intronic chr10:105102850(-) A-I      intronic chr10:105104388(-) A-I      intronic chr10:105085135(-) A-I      intronic chr10:105066019(-) A-I      intronic chr10:105083631(-) A-I      intronic chr10:105088503(-) A-I      intronic chr10:105084707(-) A-I      intronic chr10:105083764(-) A-I      intronic chr10:105098978(-) A-I      intronic chr10:105100521(-) A-I      intronic chr10:105064008(-) A-I      intronic chr10:105067252(-) A-I      intronic chr10:105089989(-) A-I      intronic chr10:105064053(-) A-I      intronic chr10:105105363(-) A-I      intronic chr10:105094901(-) A-I      intronic chr10:105083561(-) A-I      intronic chr10:105064292(-) A-I      intronic chr10:105083106(-) A-I      intronic chr10:105084662(-) A-I      intronic chr10:105078267(-) A-I      intronic chr10:105065096(-) A-I      intronic chr10:105065221(-) A-I      intronic chr10:105078343(-) A-I      intronic chr10:105095780(-) A-I      intronic chr10:105078999(-) A-I      intronic chr10:105065231(-) A-I      intronic chr10:105099851(-) A-I      intronic chr10:105066695(-) A-I      intronic chr10:105064050(-) A-I      intronic chr10:105095062(-) A-I      intronic chr10:105104600(-) A-I      intronic chr10:105085149(-) A-I      intronic chr10:105064330(-) A-I      intronic chr10:105099920(-) A-I      intronic chr10:105071601(-) A-I      intronic chr10:105069564(-) A-I      intronic chr10:105065210(-) A-I      intronic chr10:105099422(-) A-I      intronic chr10:105083412(-) A-I      intronic chr10:105100821(-) A-I      intronic chr10:105101490(-) A-I      intronic chr10:105086861(-) A-I      intronic chr10:105101894(-) A-I      intronic chr10:105096516(-) A-I      intronic chr10:105069846(-) A-I      intronic chr10:105082459(-) A-I      intronic chr10:105082018(-) A-I      intronic chr10:105064957(-) A-I      intronic chr10:105102059(-) A-I      intronic chr10:105094896(-) A-I      intronic chr10:105100742(-) A-I      intronic chr10:105067409(-) A-I      intronic chr10:105096520(-) A-I      intronic chr10:105083863(-) A-I      intronic chr10:105109340(-) A-I      intronic chr10:105065560(-) A-I      intronic chr10:105100451(-) A-I      intronic chr10:105100606(-) A-I      intronic chr10:105083474(-) A-I      intronic chr10:105088703(-) A-I      intronic chr10:105083191(-) A-I      intronic chr10:105086966(-) A-I      intronic chr10:105092755(-) A-I      intronic chr10:105087006(-) A-I      intronic chr10:105092314(-) A-I      intronic chr10:105084726(-) A-I      intronic chr10:105096414(-) A-I      intronic chr10:105085175(-) A-I      intronic chr10:105065206(-) A-I      intronic chr10:105080434(-) A-I      intronic chr10:105083478(-) A-I      intronic chr10:105098986(-) A-I      intronic chr10:105075059(-) A-I      intronic chr10:105091261(-) A-I      intronic chr10:105100479(-) A-I      intronic chr10:105071906(-) A-I      intronic chr10:105083864(-) A-I      intronic chr10:105077291(-) A-I      intronic chr10:105099452(-) A-I      intronic chr10:105087650(-) A-I      intronic chr10:105081006(-) A-I      intronic chr10:105087596(-) A-I      intronic chr10:105069453(-) A-I      intronic chr10:105090063(-) A-I      intronic chr10:105099061(-) A-I      intronic chr10:105090428(-) A-I      intronic chr10:105097915(-) A-I      intronic chr10:105081039(-) A-I      intronic chr10:105101428(-) A-I      intronic chr10:105091618(-) A-I      intronic chr10:105095258(-) A-I      intronic chr10:105095566(-) A-I      intronic chr10:105099686(-) A-I      intronic chr10:105099516(-) A-I      intronic chr10:105089363(-) A-I      intronic chr10:105070600(-) A-I      intronic chr10:105104185(-) A-I      intronic chr10:105065587(-) A-I      intronic chr10:105092675(-) A-I      intronic chr10:105091678(-) A-I      intronic chr10:105087570(-) A-I      intronic chr10:105064267(-) A-I      intronic chr10:105095368(-) A-I      intronic chr10:105071275(-) A-I      intronic chr10:105099822(-) A-I      intronic chr10:105094869(-) A-I      intronic chr10:105085727(-) A-I      intronic chr10:105083192(-) A-I      intronic chr10:105104362(-) A-I      intronic chr10:105083834(-) A-I      intronic chr10:105092079(-) A-I      intronic chr10:105091822(-) A-I      intronic chr10:105070584(-) A-I      intronic chr10:105083769(-) A-I      intronic chr10:105068372(-) A-I      intronic chr10:105064590(-) A-I      intronic chr10:105068587(-) A-I      intronic chr10:105095390(-) A-I      intronic chr10:105090497(-) A-I      intronic chr10:105100482(-) A-I      intronic chr10:105086914(-) A-I      intronic chr10:105106440(-) A-I      intronic chr10:105091821(-) A-I      intronic chr10:105077540(-) A-I      intronic chr10:105092722(-) A-I      intronic chr10:105106466(-) A-I      intronic chr10:105101116(-) A-I      intronic chr10:105101335(-) A-I      intronic chr10:105073134(-) A-I      intronic chr10:105077344(-) A-I      intronic chr10:105085751(-) A-I      intronic chr10:105066855(-) A-I      intronic chr10:105096435(-) A-I      intronic chr10:105085781(-) A-I      intronic chr10:105104157(-) A-I      intronic chr10:105067509(-) A-I      intronic chr10:105086960(-) A-I      intronic chr10:105066610(-) A-I      intronic chr10:105064934(-) A-I      intronic chr10:105071306(-) A-I      intronic chr10:105075463(-) A-I      intronic chr10:105100804(-) A-I      intronic chr10:105079012(-) A-I      intronic chr10:105064379(-) A-I      intronic chr10:105078140(-) A-I      intronic chr10:105077395(-) A-I      intronic chr10:105092139(-) A-I      intronic chr10:105106435(-) A-I      intronic chr10:105073270(-) A-I      intronic chr10:105092874(-) A-I      intronic chr10:105080992(-) A-I      intronic chr10:105070633(-) A-I      intronic chr10:105070882(-) A-I      intronic chr10:105080441(-) A-I      intronic chr10:105077352(-) A-I      intronic chr10:105084294(-) A-I      intronic chr10:105083506(-) A-I      intronic chr10:105095773(-) A-I      intronic chr10:105087041(-) A-I      intronic chr10:105100556(-) A-I      intronic chr10:105066130(-) A-I      intronic chr10:105103478(-) A-I      intronic chr10:105092771(-) A-I      intronic chr10:105084434(-) A-I      intronic chr10:105096397(-) A-I      intronic chr10:105070704(-) A-I      intronic chr10:105077324(-) A-I      intronic chr10:105084454(-) A-I      intronic chr10:105094911(-) A-I      intronic chr10:105101852(-) A-I      intronic chr10:105085898(-) A-I      intronic chr10:105083325(-) A-I      intronic chr10:105080361(-) A-I      intronic chr10:105088561(-) A-I      intronic chr10:105070844(-) A-I      intronic chr10:105089700(-) A-I      intronic chr10:105091239(-) A-I      intronic chr10:105081032(-) A-I      intronic chr10:105088598(-) A-I      intronic chr10:105084810(-) A-I      intronic chr10:105104564(-) A-I      intronic chr10:105100632(-) A-I      intronic chr10:105069751(-) A-I      intronic chr10:105086930(-) A-I      intronic chr10:105099812(-) A-I      intronic chr10:105102960(-) A-I      intronic chr10:105075491(-) A-I      intronic chr10:105083889(-) A-I      intronic chr10:105098926(-) A-I      intronic chr10:105068597(-) A-I      intronic chr10:105067424(-) A-I      intronic chr10:105092709(-) A-I      intronic chr10:105085664(-) A-I      intronic chr10:105095293(-) A-I      intronic chr10:105075081(-) A-I      intronic chr10:105091179(-) A-I      intronic chr10:105088619(-) A-I      intronic chr10:105101820(-) A-I      intronic chr10:105064344(-) A-I      intronic chr10:105064209(-) A-I      intronic chr10:105091125(-) A-I      intronic chr10:105101394(-) A-I      intronic chr10:105100564(-) A-I      intronic chr10:105064589(-) A-I      intronic chr10:105086959(-) A-I      intronic chr10:105095503(-) A-I      intronic chr10:105099095(-) A-I      intronic chr10:105099731(-) A-I      intronic chr10:105091072(-) A-I      intronic chr10:105078088(-) A-I      intronic chr10:105066721(-) A-I      intronic chr10:105069597(-) A-I      intronic chr10:105090519(-) A-I      intronic chr10:105075040(-) A-I      intronic chr10:105090091(-) A-I      intronic chr10:105104522(-) A-I      intronic chr10:105070666(-) A-I      intronic chr10:105089433(-) A-I      intronic chr10:105085573(-) A-I      intronic chr10:105102093(-) A-I      intronic chr10:105102270(-) A-I      intronic chr10:105095672(-) A-I      intronic chr10:105086024(-) A-I      intronic chr10:105101178(-) A-I      intronic chr10:105070843(-) A-I      intronic chr10:105092091(-) A-I      intronic chr10:105101049(-) A-I      intronic chr10:105095346(-) A-I      intronic chr10:105083271(-) A-I      intronic chr10:105103543(-) A-I      intronic chr10:105102194(-) A-I      intronic chr10:105104531(-) A-I      intronic chr10:105098946(-) A-I      intronic chr10:105085139(-) A-I      intronic chr10:105077336(-) A-I      intronic chr10:105080344(-) A-I      intronic chr10:105067775(-) A-I      intronic chr10:105100874(-) A-I      intronic chr10:105077786(-) A-I      intronic chr10:105071141(-) A-I      intronic chr10:105087711(-) A-I      intronic chr10:105079045(-) A-I      intronic chr10:105099025(-) A-I      intronic chr10:105073165(-) A-I      intronic chr10:105066704(-) A-I      intronic chr10:105096630(-) A-I      intronic chr10:105099064(-) A-I      intronic chr10:105081281(-) A-I      intronic chr10:105092615(-) A-I      intronic chr10:105095090(-) A-I      intronic chr10:105098517(-) A-I      intronic chr10:105099460(-) A-I      intronic chr10:105101863(-) A-I      intronic chr10:105077541(-) A-I      intronic chr10:105094920(-) A-I      intronic chr10:105083825(-) A-I      intronic chr10:105099664(-) A-I      intronic chr10:105091242(-) A-I      intronic chr10:105065301(-) A-I      intronic chr10:105069981(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PCGF6	chr10:105070584(-) A-G intron -    22484847 chr10:105081032(-) A-G intron -    22484847 chr10:105095062(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PCGF6	chr10:105063472-105063473(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:105063555-105063556(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:105063612-105063613(-) m6A 3'UTR//exon       27773535 chr10:105110482-105110483(-) m6A CDS//exon       25456834//24981863//27773536 chr10:105110524-105110525(-) m6A CDS//exon       25456834//24981863//27371828//27773536 chr10:105110542-105110543(-) m1A CDS//exon       26863196 chr10:105110566-105110567(-) m1A CDS//exon       26863196 chr10:105110691-105110692(-) m6A CDS//exon       27371828//27773536 chr10:105110774-105110775(-) m6A CDS//exon       27773536 chr10:105110871-105110872(-) m6A 5'UTR       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PCGF6	Chromatin K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: PCGF6

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Prediction-Evidence	miRanda//Targetscan
Support Database	VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.