Basic Information:

  VIRBase ID:  

VHID00376194

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9523

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          GNPTAB:  NM_024312     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	GNPTAB
miRBase Accession/Entrez ID	MIMAT0003717	79158
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GNPTA//ICD

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GNPTAB	chr12:102169305(-) A-I      intronic chr12:102187856(-) A-I      intronic chr12:102206277(-) A-I      intronic chr12:102206289(-) A-I      intronic chr12:102209045(-) A-I      intronic chr12:102209084(-) A-I      intronic chr12:102218439(-) A-I      intronic chr12:102218440(-) A-I      intronic chr12:102175226(-) A-I      intronic chr12:102175363(-) A-I      intronic chr12:102139620(-) A-I      3'UTR chr12:102139614(-) A-I      3'UTR chr12:102139595(-) A-I      3'UTR chr12:102139567(-) A-I      3'UTR chr12:102221497(-) A-I      intronic chr12:102211570(-) A-I      intronic chr12:102221662(-) A-I      intronic chr12:102221676(-) A-I      intronic chr12:102221693(-) A-I      intronic chr12:102224198(-) A-I      intronic chr12:102207911(-) A-I      intronic chr12:102202559(-) A-I      intronic chr12:102221669(-) A-I      intronic chr12:102217266(-) A-I      intronic chr12:102216024(-) A-I      intronic chr12:102199454(-) A-I      intronic chr12:102206884(-) A-I      intronic chr12:102188192(-) A-I      intronic chr12:102205996(-) A-I      intronic chr12:102217222(-) A-I      intronic chr12:102205901(-) A-I      intronic chr12:102217276(-) A-I      intronic chr12:102208961(-) A-I      intronic chr12:102217305(-) A-I      intronic chr12:102187673(-) A-I      intronic chr12:102212957(-) A-I      intronic chr12:102206341(-) A-I      intronic chr12:102212304(-) A-I      intronic chr12:102197799(-) A-I      intronic chr12:102179129(-) A-I      intronic chr12:102209090(-) A-I      intronic chr12:102208994(-) A-I      intronic chr12:102206755(-) A-I      intronic chr12:102152897(-) A-I      intronic chr12:102206515(-) A-I      intronic chr12:102206493(-) A-I      intronic chr12:102206427(-) A-I      intronic chr12:102206417(-) A-I      intronic chr12:102221577(-) A-I      intronic chr12:102216042(-) A-I      intronic chr12:102179097(-) A-I      intronic chr12:102206370(-) A-I      intronic chr12:102209307(-) A-I      intronic chr12:102221152(-) A-I      intronic chr12:102187820(-) A-I      intronic chr12:102187619(-) A-I      intronic chr12:102151996(-) A-I      intronic chr12:102189448(-) A-I      intronic chr12:102217325(-) A-I      intronic chr12:102206621(-) A-I      intronic chr12:102212213(-) A-I      intronic chr12:102209098(-) A-I      intronic chr12:102208967(-) A-I      intronic chr12:102152228(-) A-I      intronic chr12:102160213(-) A-I      intronic chr12:102217336(-) A-I      intronic chr12:102212338(-) A-I      intronic chr12:102160224(-) A-I      intronic chr12:102160292(-) A-I      intronic chr12:102175227(-) A-I      intronic chr12:102175242(-) A-I      intronic chr12:102169234(-) A-I      intronic chr12:102177746(-) A-I      intronic chr12:102152220(-) A-I      intronic chr12:102199196(-) A-I      intronic chr12:102221498(-) A-I      intronic chr12:102175323(-) A-I      intronic chr12:102177769(-) A-I      intronic chr12:102187733(-) A-I      intronic chr12:102187762(-) A-I      intronic chr12:102179197(-) A-I      intronic chr12:102199406(-) A-I      intronic chr12:102207929(-) A-I      intronic chr12:102161517(-) A-I      intronic chr12:102216043(-) A-I      intronic chr12:102205864(-) A-I      intronic chr12:102221265(-) A-I      intronic chr12:102177528(-) A-I      intronic chr12:102218422(-) A-I      intronic chr12:102187754(-) A-I      intronic chr12:102187848(-) A-I      intronic chr12:102206316(-) A-I      intronic chr12:102189387(-) A-I      intronic chr12:102218424(-) A-I      intronic chr12:102189409(-) A-I      intronic chr12:102220818(-) A-I      intronic chr12:102211161(-) A-I      intronic chr12:102218418(-) A-I      intronic chr12:102189422(-) A-I      intronic chr12:102189431(-) A-I      intronic chr12:102183346(-) A-I      intronic chr12:102197830(-) A-I      intronic chr12:102206720(-) A-I      intronic chr12:102223180(-) A-I      intronic chr12:102187737(-) A-I      intronic chr12:102205907(-) A-I      intronic chr12:102165094(-) A-I      intronic chr12:102199416(-) A-I      intronic chr12:102218383(-) A-I      intronic chr12:102199441(-) A-I      intronic chr12:102208984(-) A-I      intronic chr12:102152226(-) A-I      intronic chr12:102161652(-) A-I      intronic chr12:102175458(-) A-I      intronic chr12:102188182(-) A-I      intronic chr12:102218427(-) A-I      intronic chr12:102152907(-) A-I      intronic chr12:102202694(-) A-I      intronic chr12:102217210(-) A-I      intronic chr12:102217260(-) A-I      intronic chr12:102205527(-) A-I      intronic chr12:102189523(-) A-I      intronic chr12:102152084(-) A-I      intronic chr12:102177699(-) A-I      intronic chr12:102189487(-) A-I      intronic chr12:102152244(-) A-I      intronic chr12:102205554(-) A-I      intronic chr12:102208977(-) A-I      intronic chr12:102205561(-) A-I      intronic chr12:102199201(-) A-I      intronic chr12:102205585(-) A-I      intronic chr12:102214778(-) A-I      intronic chr12:102218312(-) A-I      intronic chr12:102199242(-) A-I      intronic chr12:102208025(-) A-I      intronic chr12:102205800(-) A-I      intronic chr12:102221009(-) A-I      intronic chr12:102205941(-) A-I      intronic chr12:102206710(-) A-I      intronic chr12:102217225(-) A-I      intronic chr12:102175455(-) A-I      intronic chr12:102205964(-) A-I      intronic chr12:102218448(-) A-I      intronic chr12:102212963(-) A-I      intronic chr12:102206680(-) A-I      intronic chr12:102175209(-) A-I      intronic chr12:102189521(-) A-I      intronic chr12:102187759(-) A-I      intronic chr12:102209050(-) A-I      intronic chr12:102188175(-) A-I      intronic chr12:102197979(-) A-I      intronic chr12:102187858(-) A-I      intronic chr12:102160304(-) A-I      intronic chr12:102169317(-) A-I      intronic chr12:102188235(-) A-I      intronic chr12:102189419(-) A-I      intronic chr12:102188170(-) A-I      intronic chr12:102216188(-) A-I      intronic chr12:102206454(-) A-I      intronic chr12:102152025(-) A-I      intronic chr12:102187853(-) A-I      intronic chr12:102211184(-) A-I      intronic chr12:102220893(-) A-I      intronic chr12:102223045(-) A-I      intronic chr12:102217123(-) A-I      intronic chr12:102175181(-) A-I      intronic chr12:102187706(-) A-I      intronic chr12:102166777(-) A-I      intronic chr12:102187815(-) A-I      intronic chr12:102183379(-) A-I      intronic chr12:102177530(-) A-I      intronic chr12:102177641(-) A-I      intronic chr12:102211206(-) A-I      intronic chr12:102217326(-) A-I      intronic chr12:102212335(-) A-I      intronic chr12:102179176(-) A-I      intronic chr12:102199401(-) A-I      intronic chr12:102217200(-) A-I      intronic chr12:102177713(-) A-I      intronic chr12:102206656(-) A-I      intronic chr12:102197909(-) A-I      intronic chr12:102183309(-) A-I      intronic chr12:102206706(-) A-I      intronic chr12:102211157(-) A-I      intronic chr12:102187726(-) A-I      intronic chr12:102209338(-) A-I      intronic chr12:102205537(-) A-I      intronic chr12:102212344(-) A-I      intronic chr12:102221067(-) A-I      intronic chr12:102221185(-) A-I      intronic chr12:102221659(-) A-I      intronic chr12:102224237(-) A-I      intronic chr12:102161651(-) A-I      intronic chr12:102187872(-) A-I      intronic chr12:102218497(-) A-I      intronic chr12:102218360(-) A-I      intronic chr12:102175331(-) A-I      intronic chr12:102221632(-) A-I      intronic chr12:102206372(-) A-I      intronic chr12:102218496(-) A-I      intronic chr12:102175187(-) A-I      intronic chr12:102161539(-) A-I      intronic chr12:102211520(-) A-I      intronic chr12:102218462(-) A-I      intronic chr12:102175351(-) A-I      intronic chr12:102221707(-) A-I      intronic chr12:102221737(-) A-I      intronic chr12:102221499(-) A-I      intronic chr12:102203876(-) A-I      intronic chr12:102206280(-) A-I      intronic chr12:102217122(-) A-I      intronic chr12:102211578(-) A-I      intronic chr12:102151955(-) A-I      intronic chr12:102161511(-) A-I      intronic chr12:102217143(-) A-I      intronic chr12:102165268(-) A-I      intronic chr12:102175381(-) A-I      intronic chr12:102188665(-) A-I      intronic chr12:102206455(-) A-I      intronic chr12:102195102(-) A-I      intronic chr12:102221580(-) A-I      intronic chr12:102169254(-) A-I      intronic chr12:102187750(-) A-I      intronic chr12:102187760(-) A-I      intronic chr12:102146859(-) A-I      intronic chr12:102160294(-) A-I      intronic chr12:102209000(-) A-I      intronic chr12:102212258(-) A-I      intronic chr12:102207521(-) A-I      intronic chr12:102175431(-) A-I      intronic chr12:102188679(-) A-I      intronic chr12:102175448(-) A-I      intronic chr12:102221295(-) A-I      intronic chr12:102175200(-) A-I      intronic chr12:102218313(-) A-I      intronic chr12:102175278(-) A-I      intronic chr12:102146902(-) A-I      intronic chr12:102212223(-) A-I      intronic chr12:102177569(-) A-I      intronic chr12:102205923(-) A-I      intronic chr12:102152898(-) A-I      intronic chr12:102224240(-) A-I      intronic chr12:102212949(-) A-I      intronic chr12:102169302(-) A-I      intronic chr12:102206624(-) A-I      intronic chr12:102221229(-) A-I      intronic chr12:102217131(-) A-I      intronic chr12:102217240(-) A-I      intronic chr12:102151890(-) A-I      intronic chr12:102169307(-) A-I      intronic chr12:102206681(-) A-I      intronic chr12:102188242(-) A-I      intronic chr12:102221563(-) A-I      intronic chr12:102217288(-) A-I      intronic chr12:102205555(-) A-I      intronic chr12:102160253(-) A-I      intronic chr12:102221245(-) A-I      intronic chr12:102212294(-) A-I      intronic chr12:102175199(-) A-I      intronic chr12:102177747(-) A-I      intronic chr12:102189287(-) A-I      intronic chr12:102211216(-) A-I      intronic chr12:102206422(-) A-I      intronic chr12:102206616(-) A-I      intronic chr12:102177621(-) A-I      intronic chr12:102197837(-) A-I      intronic chr12:102205939(-) A-I      intronic chr12:102175341(-) A-I      intronic chr12:102208912(-) A-I      intronic chr12:102177630(-) A-I      intronic chr12:102188261(-) A-I      intronic chr12:102189484(-) A-I      intronic chr12:102188209(-) A-I      intronic chr12:102220837(-) A-I      intronic chr12:102161599(-) A-I      intronic chr12:102211492(-) A-I      intronic chr12:102220897(-) A-I      intronic chr12:102161584(-) A-I      intronic chr12:102177637(-) A-I      intronic chr12:102211197(-) A-I      intronic chr12:102206810(-) A-I      intronic chr12:102205937(-) A-I      intronic chr12:102152171(-) A-I      intronic chr12:102175402(-) A-I      intronic chr12:102206523(-) A-I      intronic chr12:102187893(-) A-I      intronic chr12:102217341(-) A-I      intronic chr12:102169346(-) A-I      intronic chr12:102193988(-) A-I      intronic chr12:102189368(-) A-I      intronic chr12:102208943(-) A-I      intronic chr12:102179246(-) A-I      intronic chr12:102177657(-) A-I      intronic chr12:102187902(-) A-I      intronic chr12:102187888(-) A-I      intronic chr12:102223141(-) A-I      intronic chr12:102218438(-) A-I      intronic chr12:102209328(-) A-I      intronic chr12:102175315(-) A-I      intronic chr12:102169306(-) A-I      intronic chr12:102209258(-) A-I      intronic chr12:102177771(-) A-I      intronic chr12:102208363(-) A-I      intronic chr12:102205988(-) A-I      intronic chr12:102209089(-) A-I      intronic chr12:102211516(-) A-I      intronic chr12:102208415(-) A-I      intronic chr12:102169230(-) A-I      intronic chr12:102208928(-) A-I      intronic chr12:102152952(-) A-I      intronic chr12:102202700(-) A-I      intronic chr12:102187894(-) A-I      intronic chr12:102218505(-) A-I      intronic chr12:102195069(-) A-I      intronic chr12:102209303(-) A-I      intronic chr12:102151954(-) A-I      intronic chr12:102187681(-) A-I      intronic chr12:102139627(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GNPTAB	chr12:102187820(-) A-I intron -    22327324 chr12:102188209(-) A-I intron -    21960545 chr12:102188273(-) A-I intron -    21960545 chr12:102209303(-) A-I intron -    21960545 chr12:102139751(-) T-C exon 3'UTR    22484847 chr12:102165268(-) A-G intron -    22484847 chr12:102175431(-) A-G intron -    22484847 chr12:102177699(-) A-G intron -    22484847 chr12:102187820(-) A-G intron -    22484847 chr12:102187858(-) A-G intron -    22484847 chr12:102188665(-) A-G intron -    22484847 chr12:102188679(-) A-G intron -    22484847 chr12:102211157(-) A-G intron -    22484847 chr12:102212949(-) A-G intron -    22484847 chr12:102217336(-) A-G intron -    22484847 chr12:102223252(-) C-T intron -    22484847 chr12:102139657(-) T-C exon 3'UTR    22484847 chr12:102151954(-) A-G intron -    22484847 chr12:102152025(-) A-G intron -    22484847 chr12:102152084(-) A-G intron -    22484847 chr12:102152907(-) A-G intron -    22484847 chr12:102152952(-) A-G intron -    22484847 chr12:102161511(-) A-G intron -    22484847 chr12:102161517(-) A-G intron -    22484847 chr12:102161539(-) A-G intron -    22484847 chr12:102161651(-) A-G intron -    22484847 chr12:102161652(-) A-G intron -    22484847 chr12:102169254(-) A-G intron -    22484847 chr12:102172621(-) A-G intron -    22484847 chr12:102175278(-) A-G intron -    22484847 chr12:102175448(-) A-G intron -    22484847 chr12:102175455(-) A-G intron -    22484847 chr12:102177747(-) A-G intron -    22484847 chr12:102177771(-) A-G intron -    22484847 chr12:102187681(-) A-G intron -    22484847 chr12:102187706(-) A-G intron -    22484847 chr12:102187759(-) A-G intron -    22484847 chr12:102187760(-) A-G intron -    22484847 chr12:102187762(-) A-G intron -    22484847 chr12:102187815(-) A-G intron -    22484847 chr12:102187853(-) A-G intron -    22484847 chr12:102187872(-) A-G intron -    22484847 chr12:102187893(-) A-G intron -    22484847 chr12:102187894(-) A-G intron -    22484847 chr12:102187902(-) A-G intron -    22484847 chr12:102188192(-) A-G intron -    22484847 chr12:102188209(-) A-G intron -    22484847 chr12:102188261(-) A-G intron -    22484847 chr12:102189368(-) A-G intron -    22484847 chr12:102189419(-) A-G intron -    22484847 chr12:102189448(-) A-G intron -    22484847 chr12:102189521(-) A-G intron -    22484847 chr12:102189523(-) A-G intron -    22484847 chr12:102197837(-) A-G intron -    22484847 chr12:102197909(-) A-G intron -    22484847 chr12:102197979(-) A-G intron -    22484847 chr12:102199196(-) A-G intron -    22484847 chr12:102199401(-) A-G intron -    22484847 chr12:102199454(-) A-G intron -    22484847 chr12:102202700(-) A-G intron -    22484847 chr12:102205537(-) A-G intron -    22484847 chr12:102205555(-) A-G intron -    22484847 chr12:102205864(-) A-G intron -    22484847 chr12:102205907(-) A-G intron -    22484847 chr12:102205923(-) A-G intron -    22484847 chr12:102205937(-) A-G intron -    22484847 chr12:102205939(-) A-G intron -    22484847 chr12:102206372(-) A-G intron -    22484847 chr12:102206454(-) A-G intron -    22484847 chr12:102206455(-) A-G intron -    22484847 chr12:102206523(-) A-G intron -    22484847 chr12:102206616(-) A-G intron -    22484847 chr12:102206621(-) A-G intron -    22484847 chr12:102206624(-) A-G intron -    22484847 chr12:102206810(-) A-G intron -    22484847 chr12:102206884(-) A-G intron -    22484847 chr12:102207521(-) A-G intron -    22484847 chr12:102207911(-) A-G intron -    22484847 chr12:102208025(-) A-G intron -    22484847 chr12:102208415(-) A-G intron -    22484847 chr12:102208943(-) A-G intron -    22484847 chr12:102208984(-) A-G intron -    22484847 chr12:102209000(-) A-G intron -    22484847 chr12:102209050(-) A-G intron -    22484847 chr12:102209089(-) A-G intron -    22484847 chr12:102209303(-) A-G intron -    22484847 chr12:102209328(-) A-G intron -    22484847 chr12:102211570(-) A-G intron -    22484847 chr12:102211578(-) A-G intron -    22484847 chr12:102212335(-) A-G intron -    22484847 chr12:102212344(-) A-G intron -    22484847 chr12:102217122(-) A-G intron -    22484847 chr12:102217123(-) A-G intron -    22484847 chr12:102217143(-) A-G intron -    22484847 chr12:102217200(-) A-G intron -    22484847 chr12:102217288(-) A-G intron -    22484847 chr12:102217326(-) A-G intron -    22484847 chr12:102217341(-) A-G intron -    22484847 chr12:102218462(-) A-G intron -    22484847 chr12:102218496(-) A-G intron -    22484847 chr12:102218505(-) A-G intron -    22484847 chr12:102221131(-) C-T intron -    22484847 chr12:102221669(-) A-G intron -    22484847 chr12:102221707(-) A-G intron -    22484847 chr12:102221737(-) A-G intron -    22484847 chr12:102223180(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GNPTAB	chr12:102140626-102140627(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:102140659-102140660(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:102140698-102140699(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:102140730-102140731(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr12:102140753-102140754(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr12:102140889-102140890(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr12:102140923-102140924(-) m6A 3'UTR       24284625//22608085 chr12:102151399-102151400(-) m6A CDS//exon       27773535 chr12:102151406-102151407(-) m6A CDS//exon       27773535 chr12:102153903-102153904(-) m6A CDS//exon       27773535 chr12:102154922-102154923(-) m6A CDS       27773535 chr12:102155522-102155523(-) m6A CDS       24981863//27773535 chr12:102158118-102158119(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//22608085 chr12:102158221-102158222(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr12:102158236-102158237(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr12:102158260-102158261(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr12:102158268-102158269(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr12:102158364-102158365(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr12:102158390-102158391(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr12:102158422-102158423(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:102158469-102158470(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr12:102158529-102158530(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr12:102158537-102158538(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr12:102158654-102158655(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:102158774-102158775(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr12:102158780-102158781(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr12:102158793-102158794(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr12:102158905-102158906(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr12:102182339-102182340(-) m6A CDS//exon       27371828 chr12:102182349-102182350(-) m6A CDS//exon       27371828 chr12:102183744-102183745(-) m6A CDS//exon       27371828 chr12:102183762-102183763(-) m6A CDS//exon       27371828 chr12:102183774-102183775(-) m6A CDS//exon       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GNPTAB	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: GNPTAB

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.