Basic Information:

  VIRBase ID:  

VHID00376188

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          SMIM7:  NM_001300925     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	SMIM7
miRBase Accession/Entrez ID	MIMAT0003717	79086
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C19orf42

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SMIM7	chr19:16760159(-) A-I      intronic chr19:16756710(-) A-I      3'UTR chr19:16759009(-) A-I      intronic chr19:16759067(-) A-I      intronic chr19:16756644(-) A-I      3'UTR chr19:16758388(-) A-I      intronic chr19:16756705(-) A-I      3'UTR chr19:16756691(-) A-I      3'UTR chr19:16759057(-) A-I      intronic chr19:16759017(-) A-I      intronic chr19:16758378(-) A-I      intronic chr19:16759073(-) A-I      intronic chr19:16763134(-) A-I      intronic chr19:16758415(-) A-I      intronic chr19:16763145(-) A-I      intronic chr19:16756697(-) A-I      3'UTR chr19:16769902(-) A-I      intronic chr19:16760055(-) A-I      intronic chr19:16760038(-) A-I      intronic chr19:16759588(-) A-I      intronic chr19:16759225(-) A-I      intronic chr19:16759037(-) A-I      intronic chr19:16759019(-) A-I      intronic chr19:16758989(-) A-I      intronic chr19:16758484(-) A-I      intronic chr19:16758480(-) A-I      intronic chr19:16758471(-) A-I      intronic chr19:16758470(-) A-I      intronic chr19:16759184(-) A-I      intronic chr19:16758460(-) A-I      intronic chr19:16758444(-) A-I      intronic chr19:16765466(-) A-I      intronic chr19:16763098(-) A-I      intronic chr19:16761421(-) A-I      intronic chr19:16761393(-) A-I      intronic chr19:16758434(-) A-I      intronic chr19:16758352(-) A-I      intronic chr19:16758324(-) A-I      intronic chr19:16761277(-) A-I      intronic chr19:16760382(-) A-I      intronic chr19:16760327(-) A-I      intronic chr19:16760321(-) A-I      intronic chr19:16760132(-) A-I      intronic chr19:16760302(-) A-I      intronic chr19:16760240(-) A-I      intronic chr19:16760239(-) A-I      intronic chr19:16760221(-) A-I      intronic chr19:16760207(-) A-I      intronic chr19:16760170(-) A-I      intronic chr19:16760145(-) A-I      intronic chr19:16763280(-) A-I      3'UTR chr19:16763264(-) A-I      3'UTR chr19:16763190(-) A-I      3'UTR chr19:16756762(-) A-I      3'UTR chr19:16756700(-) A-I      3'UTR chr19:16756619(-) A-I      3'UTR chr19:16756605(-) A-I      3'UTR chr19:16756569(-) A-I      3'UTR chr19:16756633(-) A-I      3'UTR chr19:16756540(-) A-I      3'UTR chr19:16756534(-) A-I      3'UTR chr19:16756502(-) A-I      3'UTR chr19:16756472(-) A-I      3'UTR chr19:16763294(-) A-I      3'UTR chr19:16759829(-) A-I      intronic chr19:16766416(-) A-I      intronic chr19:16760224(-) A-I      intronic chr19:16760271(-) A-I      intronic chr19:16764597(-) A-I      intronic chr19:16761399(-) A-I      intronic chr19:16766409(-) A-I      intronic chr19:16759705(-) A-I      intronic chr19:16759828(-) A-I      intronic chr19:16760037(-) A-I      intronic chr19:16764594(-) A-I      intronic chr19:16758475(-) A-I      intronic chr19:16761264(-) A-I      intronic chr19:16760043(-) A-I      intronic chr19:16759687(-) A-I      intronic chr19:16759049(-) A-I      intronic chr19:16761413(-) A-I      intronic chr19:16760301(-) A-I      intronic chr19:16761316(-) A-I      intronic chr19:16760262(-) A-I      intronic chr19:16763167(-) A-I      intronic chr19:16760284(-) A-I      intronic chr19:16761477(-) A-I      intronic chr19:16761355(-) A-I      intronic chr19:16763208(-) A-I      3'UTR chr19:16765424(-) A-I      intronic chr19:16761276(-) A-I      intronic chr19:16761438(-) A-I      intronic chr19:16756582(-) A-I      3'UTR chr19:16756689(-) A-I      3'UTR chr19:16756486(-) A-I      3'UTR chr19:16764623(-) A-I      intronic chr19:16765484(-) A-I      intronic chr19:16759048(-) A-I      intronic chr19:16756661(-) A-I      3'UTR chr19:16756652(-) A-I      3'UTR chr19:16756578(-) A-I      3'UTR chr19:16759826(-) A-I      intronic chr19:16758504(-) A-I      intronic chr19:16761373(-) A-I      intronic chr19:16756740(-) A-I      3'UTR chr19:16756601(-) A-I      3'UTR chr19:16768671(-) A-I      intronic chr19:16760275(-) A-I      intronic chr19:16758327(-) A-I      intronic chr19:16756651(-) A-I      3'UTR chr19:16761389(-) A-I      intronic chr19:16760332(-) A-I      intronic chr19:16756723(-) A-I      3'UTR chr19:16760230(-) A-I      intronic chr19:16756640(-) A-I      3'UTR chr19:16756610(-) A-I      3'UTR chr19:16764462(-) A-I      intronic chr19:16761519(-) A-I      intronic chr19:16756477(-) A-I      3'UTR chr19:16756746(-) A-I      3'UTR chr19:16756719(-) A-I      3'UTR chr19:16756571(-) A-I      3'UTR chr19:16756478(-) A-I      3'UTR chr19:16756545(-) A-I      3'UTR chr19:16763285(-) A-I      3'UTR chr19:16756690(-) A-I      3'UTR chr19:16760315(-) A-I      intronic chr19:16763231(-) A-I      3'UTR chr19:16756613(-) A-I      3'UTR chr19:16759134(-) A-I      intronic chr19:16767034(-) A-I      intronic chr19:16759774(-) A-I      intronic chr19:16764517(-) A-I      intronic chr19:16758334(-) A-I      intronic chr19:16759090(-) A-I      intronic chr19:16764539(-) A-I      intronic chr19:16761302(-) A-I      intronic chr19:16763151(-) A-I      intronic chr19:16756479(-) A-I      3'UTR chr19:16759080(-) A-I      intronic chr19:16761412(-) A-I      intronic chr19:16759189(-) A-I      intronic chr19:16761475(-) A-I      intronic chr19:16760340(-) A-I      intronic chr19:16759830(-) A-I      intronic chr19:16760272(-) A-I      intronic chr19:16763118(-) A-I      intronic chr19:16758405(-) A-I      intronic chr19:16759652(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMIM7	chr19:16741566-16741567(-) m6A 3'UTR//exon       27773535//22608085 chr19:16741599-16741600(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22608085 chr19:16741644-16741645(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22608085 chr19:16741663-16741664(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22608085 chr19:16741673-16741674(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22608085 chr19:16741692-16741693(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr19:16741788-16741789(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:16741806-16741807(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr19:16741834-16741835(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22608085 chr19:16741876-16741877(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828//22608085 chr19:16742243-16742244(-) m6A 3'UTR//exon       24981863 chr19:16742250-16742251(-) m6A 3'UTR//exon       24981863 chr19:16745469-16745470(-) m6A intron       - chr19:16757427-16757428(-) m6A 3'UTR//exon//intron       24981863//22608085 chr19:16757460-16757461(-) m6A 3'UTR//exon//intron       24981863//22608085 chr19:16757518-16757519(-) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr19:16757538-16757539(-) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr19:16757631-16757632(-) m6A 3'UTR//exon//intron       24284625//24981863//22575960//22608085 chr19:16757693-16757694(-) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr19:16763228-16763229(-) m6A 3'UTR//intron       - chr19:16763333-16763334(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr19:16763362-16763363(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr19:16763374-16763375(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr19:16763426-16763427(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:16763448-16763449(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:16763493-16763494(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:16763562-16763563(-) m6A 3'UTR//exon//intron       24284625//24209618//27773535//22575960//22608085 chr19:16763592-16763593(-) m6A 3'UTR//exon//intron       24284625//24209618//27773535//22575960//22608085 chr19:16763665-16763666(-) m6A 3'UTR//exon//intron       - chr19:16770246-16770247(-) m6A CDS//exon//intron       - chr19:16770498-16770499(-) m6A exon//intron       - chr19:16770778-16770779(-) m6A CDS//exon       - chr19:16770910-16770911(-) m6A CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SMIM7	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: SMIM7

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.