Basic Information:

  VIRBase ID:  

VHID00376149

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          YTHDC2:  NM_022828     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	YTHDC2
miRBase Accession/Entrez ID	MIMAT0003717	64848
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAHL//hYTHDC2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	YTHDC2	chr5:112853806(+) A-I      intronic chr5:112853719(+) A-I      intronic chr5:112853715(+) A-I      intronic chr5:112857241(+) A-I      intronic chr5:112857285(+) A-I      intronic chr5:112857353(+) A-I      intronic chr5:112925335(+) A-I      intronic chr5:112925399(+) A-I      intronic chr5:112925374(+) A-I      intronic chr5:112925370(+) A-I      intronic chr5:112925203(+) A-I      intronic chr5:112894540(+) A-I      intronic chr5:112864489(+) A-I      intronic chr5:112854002(+) A-I      intronic chr5:112857317(+) A-I      intronic chr5:112924459(+) A-I      intronic chr5:112854137(+) A-I      intronic chr5:112925381(+) A-I      intronic chr5:112894539(+) A-I      intronic chr5:112857266(+) A-I      intronic chr5:112854164(+) A-I      intronic chr5:112854138(+) A-I      intronic chr5:112854133(+) A-I      intronic chr5:112925262(+) A-I      intronic chr5:112925368(+) A-I      intronic chr5:112925267(+) A-I      intronic chr5:112857173(+) A-I      intronic chr5:112893282(+) A-I      intronic chr5:112924561(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	YTHDC2	chr5:112853991(+) A-G intron -    22484847 chr5:112854133(+) A-G intron -    22484847 chr5:112854134(+) A-G intron -    22484847 chr5:112854137(+) A-G intron -    22484847 chr5:112854138(+) A-G intron -    22484847 chr5:112857251(+) A-G intron -    22484847 chr5:112906050(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	YTHDC2	chr5:112860827-112860828(+) m6A CDS//intron       24981863 chr5:112927754-112927755(+) m6A CDS//exon       24981863 chr5:112929007-112929008(+) m6A CDS//exon       22608085 chr5:112929022-112929023(+) m6A CDS//exon       22608085 chr5:112929066-112929067(+) m6A CDS//exon       24284625//24981863//22608085 chr5:112929136-112929137(+) m6A exon//intron       24284625//24981863//22608085 chr5:112929179-112929180(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929197-112929198(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929241-112929242(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929301-112929302(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929542-112929543(+) m6A 3'UTR//exon       24981863//22608085 chr5:112929593-112929594(+) m6A 3'UTR//exon       24981863//22608085 chr5:112929630-112929631(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929642-112929643(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929655-112929656(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929737-112929738(+) m6A 3'UTR//exon       27773535 chr5:112930025-112930026(+) m6A 3'UTR//exon       24981863 chr5:112930042-112930043(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	YTHDC2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: YTHDC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.