Basic Information:

  VIRBase ID:  

VHID00376018

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9092

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          MRS2:  NM_020662     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	MRS2
miRBase Accession/Entrez ID	MIMAT0003717	57380
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HPT//MRS2L

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MRS2	chr6:24411947(+) A-I      intronic chr6:24411260(+) A-I      intronic chr6:24410839(+) A-I      intronic chr6:24410862(+) A-I      intronic chr6:24411262(+) A-I      intronic chr6:24411267(+) A-I      intronic chr6:24411275(+) A-I      intronic chr6:24411297(+) A-I      intronic chr6:24411298(+) A-I      intronic chr6:24411836(+) A-I      intronic chr6:24411906(+) A-I      intronic chr6:24411908(+) A-I      intronic chr6:24411255(+) A-I      intronic chr6:24412017(+) A-I      intronic chr6:24412039(+) A-I      intronic chr6:24416296(+) A-I      intronic chr6:24411252(+) A-I      intronic chr6:24411928(+) A-I      intronic chr6:24410859(+) A-I      intronic chr6:24411257(+) A-I      intronic chr6:24410803(+) A-I      intronic chr6:24411860(+) A-I      intronic chr6:24410858(+) A-I      intronic chr6:24411941(+) A-I      intronic chr6:24411950(+) A-I      intronic chr6:24411307(+) A-I      intronic chr6:24416343(+) A-I      intronic chr6:24411258(+) A-I      intronic chr6:24410387(+) A-I      intronic chr6:24419211(+) A-I      ncRNA chr6:24418885(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MRS2	chr6:24423594(+) A-I intron -    19478186 chr6:24411941(+) A-I intron -    22327324 chr6:24405397(+) T-G exon CDS    21725310 chr6:24410304(+) T-C intron -    22484847 chr6:24411252(+) A-G intron -    22484847 chr6:24411257(+) A-G intron -    22484847 chr6:24411258(+) A-G intron -    22484847 chr6:24411307(+) A-G intron -    22484847 chr6:24411860(+) A-G intron -    22484847 chr6:24411941(+) A-G intron -    22484847 chr6:24411950(+) A-G intron -    22484847 chr6:24418885(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MRS2	chr6:24403321-24403322(+) m6A CDS//exon       24284625//25456834//24981863 chr6:24405415-24405416(+) m6A CDS//exon       - chr6:24423698-24423699(+) m6A 3'UTR//intron       25456834//24981863 chr6:24423832-24423833(+) m6A CDS       25456834//24981863 chr6:24423876-24423877(+) m6A CDS       25456834//24981863 chr6:24423885-24423886(+) m6A CDS       25456834//24981863 chr6:24423888-24423889(+) Tm CDS       - chr6:24423914-24423915(+) m6A CDS       25456834//24981863 chr6:24423924-24423925(+) m6A 3'UTR       24981863 chr6:24423969-24423970(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MRS2	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: MRS2

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.