Basic Information:

  VIRBase ID:  

VHID00375999

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9092

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          C12orf4:  NM_001346155     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	C12orf4
miRBase Accession/Entrez ID	MIMAT0003717	57102
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C12orf4	chr12:4635860(-) A-I      intronic chr12:4614112(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C12orf4	chr12:4598472-4598473(-) m6A 3'UTR       27773535 chr12:4598487-4598488(-) m6A 3'UTR       27773535 chr12:4598554-4598555(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598585-4598586(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598593-4598594(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598668-4598669(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598684-4598685(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598706-4598707(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598777-4598778(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598801-4598802(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598830-4598831(-) m6A 3'UTR       24981863//27773535//22608085 chr12:4598871-4598872(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:4598920-4598921(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:4598931-4598932(-) m6A 3'UTR       24284625//24981863//22608085 chr12:4598971-4598972(-) m6A 3'UTR       24284625//24981863//22608085 chr12:4609413-4609414(-) Y 3'UTR//CDS       26075521 chr12:4634108-4634109(-) m6A exon//intron       27773535 chr12:4634126-4634127(-) m6A exon//intron       27773535 chr12:4634440-4634441(-) m6A CDS//exon       24981863//27773535 chr12:4634449-4634450(-) m6A CDS//exon       24981863//27773535 chr12:4634460-4634461(-) m6A CDS//exon       24981863//27773535 chr12:4634487-4634488(-) m6A CDS//exon       24981863//27773535 chr12:4634508-4634509(-) m6A CDS//exon       24981863//27773535 chr12:4639078-4639079(-) m6A 5'UTR//CDS//intron       24981863 chr12:4645349-4645350(-) m6A CDS//exon//intron       24981863 chr12:4647583-4647584(-) m6A 5'UTR//exon       24981863 chr12:4647591-4647592(-) m6A 5'UTR//exon       24981863 chr12:4647601-4647602(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	C12orf4	Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: C12orf4

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.