Basic Information:

  VIRBase ID:  

VHID00375852

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9092

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          ZWILCH:  NM_001287822     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	ZWILCH
miRBase Accession/Entrez ID	MIMAT0003717	55055
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	hZwilch//KNTC1AP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZWILCH	chr15:66804826(+) A-I      intronic chr15:66804804(+) A-I      intronic chr15:66835935(+) A-I      intronic chr15:66835934(+) A-I      intronic chr15:66835933(+) A-I      intronic chr15:66835886(+) A-I      intronic chr15:66835893(+) A-I      intronic chr15:66835913(+) A-I      intronic chr15:66835932(+) A-I      intronic chr15:66835936(+) A-I      intronic chr15:66803699(+) A-I      intronic chr15:66803971(+) A-I      intronic chr15:66830984(+) A-I      intronic chr15:66803982(+) A-I      intronic chr15:66804034(+) A-I      intronic chr15:66804083(+) A-I      intronic chr15:66804099(+) A-I      intronic chr15:66804103(+) A-I      intronic chr15:66806039(+) A-I      intronic chr15:66840387(+) A-I      intronic chr15:66836799(+) A-I      intronic chr15:66836015(+) A-I      intronic chr15:66804158(+) A-I      intronic chr15:66804162(+) A-I      intronic chr15:66804173(+) A-I      intronic chr15:66804214(+) A-I      intronic chr15:66804227(+) A-I      intronic chr15:66804655(+) A-I      intronic chr15:66804671(+) A-I      intronic chr15:66804972(+) A-I      intronic chr15:66799016(+) A-I      intronic chr15:66799018(+) A-I      intronic chr15:66805049(+) A-I      intronic chr15:66805749(+) A-I      intronic chr15:66836693(+) A-I      intronic chr15:66805793(+) A-I      intronic chr15:66805813(+) A-I      intronic chr15:66799389(+) A-I      intronic chr15:66799398(+) A-I      intronic chr15:66806183(+) A-I      intronic chr15:66809078(+) A-I      intronic chr15:66813933(+) A-I      intronic chr15:66813967(+) A-I      intronic chr15:66814422(+) A-I      intronic chr15:66836810(+) A-I      intronic chr15:66814863(+) A-I      intronic chr15:66840314(+) A-I      intronic chr15:66814875(+) A-I      intronic chr15:66823835(+) A-I      intronic chr15:66836946(+) A-I      intronic chr15:66823892(+) A-I      intronic chr15:66823916(+) A-I      intronic chr15:66824152(+) A-I      intronic chr15:66829773(+) A-I      intronic chr15:66805648(+) A-I      intronic chr15:66829858(+) A-I      intronic chr15:66829864(+) A-I      intronic chr15:66829890(+) A-I      intronic chr15:66830743(+) A-I      intronic chr15:66830921(+) A-I      intronic chr15:66804612(+) A-I      intronic chr15:66831576(+) A-I      intronic chr15:66831579(+) A-I      intronic chr15:66831614(+) A-I      intronic chr15:66831620(+) A-I      intronic chr15:66799473(+) A-I      intronic chr15:66831633(+) A-I      intronic chr15:66833046(+) A-I      intronic chr15:66839676(+) A-I      intronic chr15:66836725(+) A-I      intronic chr15:66802360(+) A-I      intronic chr15:66829767(+) A-I      intronic chr15:66833067(+) A-I      intronic chr15:66833128(+) A-I      intronic chr15:66802395(+) A-I      intronic chr15:66833148(+) A-I      intronic chr15:66833153(+) A-I      intronic chr15:66833066(+) A-I      intronic chr15:66833478(+) A-I      intronic chr15:66833580(+) A-I      intronic chr15:66833505(+) A-I      intronic chr15:66802631(+) A-I      intronic chr15:66824047(+) A-I      intronic chr15:66836879(+) A-I      intronic chr15:66832873(+) A-I      intronic chr15:66824389(+) A-I      intronic chr15:66833233(+) A-I      intronic chr15:66806116(+) A-I      intronic chr15:66824325(+) A-I      intronic chr15:66822795(+) A-I      intronic chr15:66833227(+) A-I      intronic chr15:66835984(+) A-I      intronic chr15:66833152(+) A-I      intronic chr15:66834776(+) A-I      intronic chr15:66799384(+) A-I      intronic chr15:66824306(+) A-I      intronic chr15:66836448(+) A-I      intronic chr15:66803986(+) A-I      intronic chr15:66823878(+) A-I      intronic chr15:66813937(+) A-I      intronic chr15:66802685(+) A-I      intronic chr15:66804080(+) A-I      intronic chr15:66824258(+) A-I      intronic chr15:66806049(+) A-I      intronic chr15:66804613(+) A-I      intronic chr15:66823899(+) A-I      intronic chr15:66830980(+) A-I      intronic chr15:66804047(+) A-I      intronic chr15:66836795(+) A-I      intronic chr15:66804977(+) A-I      intronic chr15:66814042(+) A-I      intronic chr15:66826373(+) A-I      intronic chr15:66830821(+) A-I      intronic chr15:66805458(+) A-I      intronic chr15:66804054(+) A-I      intronic chr15:66824195(+) A-I      intronic chr15:66833515(+) A-I      intronic chr15:66805026(+) A-I      intronic chr15:66824326(+) A-I      intronic chr15:66824229(+) A-I      intronic chr15:66805361(+) A-I      intronic chr15:66804079(+) A-I      intronic chr15:66822798(+) A-I      intronic chr15:66803781(+) A-I      intronic chr15:66830838(+) A-I      intronic chr15:66808944(+) A-I      intronic chr15:66801552(+) A-I      intronic chr15:66820614(+) A-I      intronic chr15:66833474(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZWILCH	chr15:66820540(+) C-T intron -    22484847 chr15:66824306(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZWILCH	chr15:66797492-66797493(+) m6A 5'UTR       24981863 chr15:66797548-66797549(+) m6A 5'UTR       24981863 chr15:66797557-66797558(+) m6A 5'UTR       24981863 chr15:66797692-66797693(+) m6A 5'UTR//CDS//exon       24981863//22608085 chr15:66797707-66797708(+) m6A 5'UTR//CDS//exon       24981863//22608085 chr15:66801213-66801214(+) m6A 5'UTR//CDS//exon//intron       24981863//22608085 chr15:66840732-66840733(+) m6A 3'UTR       24981863//22608085 chr15:66840740-66840741(+) m6A 3'UTR       24284625//24981863//22608085 chr15:66840756-66840757(+) m6A 3'UTR       24284625//24981863//22608085 chr15:66840861-66840862(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr15:66840876-66840877(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr15:66840891-66840892(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr15:66840956-66840957(+) Gm 3'UTR       - chr15:66840979-66840980(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr15:66841036-66841037(+) m6A 3'UTR       24284625//24981863//22608085 chr15:66841089-66841090(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZWILCH	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: ZWILCH

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.