Basic Information:

  VIRBase ID:  

VHID00375847

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9523

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          USP47:  NM_001372100     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	USP47
miRBase Accession/Entrez ID	MIMAT0003717	55031
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TRFP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	USP47	chr11:11975639(+) A-I      intronic chr11:11915058(+) A-I      intronic chr11:11915046(+) A-I      intronic chr11:11978578(+) A-I      3'UTR chr11:11914312(+) A-I      intronic chr11:11929388(+) A-I      intronic chr11:11929393(+) A-I      intronic chr11:11929396(+) A-I      intronic chr11:11975635(+) A-I      intronic chr11:11914304(+) A-I      intronic chr11:11915083(+) A-I      intronic chr11:11975644(+) A-I      intronic chr11:11882771(+) A-I      intronic chr11:11915109(+) A-I      intronic chr11:11929401(+) A-I      intronic chr11:11929921(+) A-I      intronic chr11:11923359(+) A-I      intronic chr11:11913952(+) A-I      intronic chr11:11882808(+) A-I      intronic chr11:11882826(+) A-I      intronic chr11:11882865(+) A-I      intronic chr11:11882905(+) A-I      intronic chr11:11929925(+) A-I      intronic chr11:11929946(+) A-I      intronic chr11:11914326(+) A-I      intronic chr11:11914033(+) A-I      intronic chr11:11915110(+) A-I      intronic chr11:11929381(+) A-I      intronic chr11:11929908(+) A-I      intronic chr11:11929966(+) A-I      intronic chr11:11975641(+) A-I      intronic chr11:11975643(+) A-I      intronic chr11:11881449(+) A-I      intronic chr11:11892971(+) A-I      intronic chr11:11881472(+) A-I      intronic chr11:11975650(+) A-I      intronic chr11:11881473(+) A-I      intronic chr11:11881499(+) A-I      intronic chr11:11881504(+) A-I      intronic chr11:11881563(+) A-I      intronic chr11:11975742(+) A-I      intronic chr11:11929938(+) A-I      intronic chr11:11975872(+) A-I      intronic chr11:11921981(+) A-I      intronic chr11:11975677(+) A-I      intronic chr11:11975891(+) A-I      intronic chr11:11913984(+) A-I      intronic chr11:11914187(+) A-I      intronic chr11:11870715(+) A-I      intronic chr11:11888538(+) A-I      intronic chr11:11975956(+) A-I      intronic chr11:11913987(+) A-I      intronic chr11:11914363(+) A-I      intronic chr11:11914265(+) A-I      intronic chr11:11915084(+) A-I      intronic chr11:11929418(+) A-I      intronic chr11:11975676(+) A-I      intronic chr11:11914046(+) A-I      intronic chr11:11893002(+) A-I      intronic chr11:11975718(+) A-I      intronic chr11:11914133(+) A-I      intronic chr11:11882759(+) A-I      intronic chr11:11914172(+) A-I      intronic chr11:11914248(+) A-I      intronic chr11:11923234(+) A-I      intronic chr11:11915096(+) A-I      intronic chr11:11975654(+) A-I      intronic chr11:11915749(+) A-I      intronic chr11:11915825(+) A-I      intronic chr11:11915832(+) A-I      intronic chr11:11923386(+) A-I      intronic chr11:11915309(+) A-I      intronic chr11:11915928(+) A-I      intronic chr11:11975747(+) A-I      intronic chr11:11923242(+) A-I      intronic chr11:11923391(+) A-I      intronic chr11:11923434(+) A-I      intronic chr11:11929948(+) A-I      intronic chr11:11915117(+) A-I      intronic chr11:11915882(+) A-I      intronic chr11:11881489(+) A-I      intronic chr11:11952277(+) A-I      NonSyn:Lys->Glu chr11:11915965(+) A-I      intronic chr11:11975916(+) A-I      intronic chr11:11975969(+) A-I      intronic chr11:11882794(+) A-I      intronic chr11:11882787(+) A-I      intronic chr11:11881553(+) A-I      intronic chr11:11881600(+) A-I      intronic chr11:11927243(+) A-I      intronic chr11:11882703(+) A-I      intronic chr11:11975743(+) A-I      intronic chr11:11882695(+) A-I      intronic chr11:11929387(+) A-I      intronic chr11:11975690(+) A-I      intronic chr11:11882686(+) A-I      intronic chr11:11914288(+) A-I      intronic chr11:11929906(+) A-I      intronic chr11:11928908(+) A-I      intronic chr11:11914176(+) A-I      intronic chr11:11914129(+) A-I      intronic chr11:11975896(+) A-I      intronic chr11:11929405(+) A-I      intronic chr11:11914256(+) A-I      intronic chr11:11893000(+) A-I      intronic chr11:11929537(+) A-I      intronic chr11:11929869(+) A-I      intronic chr11:11881373(+) A-I      intronic chr11:11975868(+) A-I      intronic chr11:11915193(+) A-I      intronic chr11:11915009(+) A-I      intronic chr11:11914328(+) A-I      intronic chr11:11975959(+) A-I      intronic chr11:11915053(+) A-I      intronic chr11:11929496(+) A-I      intronic chr11:11975998(+) A-I      intronic chr11:11929423(+) A-I      intronic chr11:11881480(+) A-I      intronic chr11:11975722(+) A-I      intronic chr11:11914283(+) A-I      intronic chr11:11975917(+) A-I      intronic chr11:11881592(+) A-I      intronic chr11:11913950(+) A-I      intronic chr11:11914180(+) A-I      intronic chr11:11913982(+) A-I      intronic chr11:11882872(+) A-I      intronic chr11:11915985(+) A-I      intronic chr11:11927179(+) A-I      intronic chr11:11915285(+) A-I      intronic chr11:11914041(+) A-I      intronic chr11:11915807(+) A-I      intronic chr11:11914102(+) A-I      intronic chr11:11923250(+) A-I      intronic chr11:11923455(+) A-I      intronic chr11:11929871(+) A-I      intronic chr11:11915162(+) A-I      intronic chr11:11915883(+) A-I      intronic chr11:11915152(+) A-I      intronic chr11:11915101(+) A-I      intronic chr11:11882768(+) A-I      intronic chr11:11929924(+) A-I      intronic chr11:11929410(+) A-I      intronic chr11:11929369(+) A-I      intronic chr11:11915169(+) A-I      intronic chr11:11882735(+) A-I      intronic chr11:11892795(+) A-I      intronic chr11:11928896(+) A-I      intronic chr11:11881547(+) A-I      intronic chr11:11915077(+) A-I      intronic chr11:11870718(+) A-I      intronic chr11:11881517(+) A-I      intronic chr11:11975982(+) A-I      intronic chr11:11881777(+) A-I      intronic chr11:11914125(+) A-I      intronic chr11:11929371(+) A-I      intronic chr11:11892796(+) A-I      intronic chr11:11929546(+) A-I      intronic chr11:11882783(+) A-I      intronic chr11:11882840(+) A-I      intronic chr11:11892812(+) A-I      intronic chr11:11975636(+) A-I      intronic chr11:11967504(+) A-I      intronic chr11:11915007(+) A-I      intronic chr11:11882741(+) A-I      intronic chr11:11915909(+) A-I      intronic chr11:11914124(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	USP47	chr11:11952277(+) A-I exon CDS    19478186 chr11:11929369(+) A-I intron -    22327324 chr11:11929371(+) A-I intron -    22327324 chr11:11915053(+) A-G intron -    22484847 chr11:11915077(+) A-G intron -    22484847 chr11:11915101(+) A-G intron -    22484847 chr11:11915110(+) A-G intron -    22484847 chr11:11915117(+) A-G intron -    22484847 chr11:11929369(+) A-G intron -    22484847 chr11:11929371(+) A-G intron -    22484847 chr11:11929906(+) A-G intron -    22484847 chr11:11929938(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	USP47	chr11:11895391-11895392(+) m1A CDS//intron       26863196 chr11:11924834-11924835(+) m6A CDS       24981863 chr11:11952272-11952273(+) m6A CDS       24981863//27773535 chr11:11954578-11954579(+) m6A CDS       24981863//27773535 chr11:11954589-11954590(+) m6A CDS       24981863//27773535 chr11:11954620-11954621(+) m6A CDS       24981863//27773535 chr11:11954632-11954633(+) m6A CDS       24981863//27773535 chr11:11955406-11955407(+) m6A CDS       24981863//27773535 chr11:11955449-11955450(+) m6A CDS       24981863 chr11:11962059-11962060(+) m6A CDS//exon       24284625 chr11:11963902-11963903(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr11:11963930-11963931(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:11963946-11963947(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:11963997-11963998(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964025-11964026(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964090-11964091(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964144-11964145(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964191-11964192(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964211-11964212(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964227-11964228(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964254-11964255(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964282-11964283(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964288-11964289(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964301-11964302(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964341-11964342(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:11964380-11964381(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11964431-11964432(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11964459-11964460(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11964520-11964521(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11964542-11964543(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11964550-11964551(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11964618-11964619(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr11:11964651-11964652(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr11:11964691-11964692(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr11:11964975-11964976(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr11:11969637-11969638(+) m6A CDS//exon       - chr11:11976635-11976636(+) m6A CDS//exon       27773535 chr11:11977554-11977555(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr11:11977595-11977596(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:11977629-11977630(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:11977634-11977635(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:11977717-11977718(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:11977806-11977807(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11977845-11977846(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11977968-11977969(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11978004-11978005(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:11978020-11978021(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:11978036-11978037(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:11978063-11978064(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:11978074-11978075(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:11978218-11978219(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr11:11978247-11978248(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr11:11978319-11978320(+) m6A 3'UTR//exon       24981863//22608085 chr11:11978332-11978333(+) m6A 3'UTR//exon       24981863//22608085 chr11:11978353-11978354(+) m6A 3'UTR//exon       24981863//22608085 chr11:11979659-11979660(+) m6A 3'UTR//exon       27773535 chr11:11979688-11979689(+) m6A 3'UTR//exon       27773535 chr11:11979696-11979697(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	USP47	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: USP47

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.