Basic Information:

  VIRBase ID:  

VHID00375826

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          MKS1:  NM_001165927     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	MKS1
miRBase Accession/Entrez ID	MIMAT0003717	54903
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BBS13//JBTS28//MES//MKS//POC12

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MKS1	chr17:56294568(-) A-I      intronic chr17:56294573(-) A-I      intronic chr17:56294514(-) A-I      intronic chr17:56295158(-) A-I      intronic chr17:56295083(-) A-I      intronic chr17:56294935(-) A-I      intronic chr17:56295084(-) A-I      intronic chr17:56294447(-) A-I      intronic chr17:56294488(-) A-I      intronic chr17:56294569(-) A-I      intronic chr17:56289101(-) A-I      intronic chr17:56294952(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MKS1	chr17:56294569(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MKS1	chr17:56282925-56282926(-) Y 3'UTR//CDS       26075521 chr17:56283327-56283328(-) m6A 3'UTR//exon       - chr17:56283347-56283348(-) m6A 3'UTR//exon       - chr17:56283406-56283407(-) m6A 3'UTR//exon       - chr17:56283453-56283454(-) m6A 3'UTR//CDS//exon       - chr17:56283473-56283474(-) m6A 3'UTR//CDS//exon       - chr17:56291133-56291134(-) m6A 3'UTR//CDS       24981863//27773535//27371828 chr17:56291208-56291209(-) m6A 3'UTR//CDS       24981863 chr17:56291637-56291638(-) m6A 3'UTR//CDS       24981863 chr17:56291656-56291657(-) m6A 3'UTR//CDS       24981863 chr17:56293460-56293461(-) Cm 3'UTR//CDS//exon//intron       - chr17:56296535-56296536(-) m6A CDS//exon//intron       24981863 chr17:56296581-56296582(-) m6A CDS//exon//intron       24284625//24981863 chr17:56296637-56296638(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MKS1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: MKS1

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Support Database	VIRmiRNA

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.