Basic Information:

  VIRBase ID:  

VHID00375807

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          KLHL24:  NR_146170     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	KLHL24
miRBase Accession/Entrez ID	MIMAT0003717	54800
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DRE1//EBSSH//KRIP6

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KLHL24	chr3:183373991(+) A-I      intronic chr3:183358649(+) A-I      intronic chr3:183358573(+) A-I      intronic chr3:183357762(+) A-I      intronic chr3:183357722(+) A-I      intronic chr3:183357582(+) A-I      intronic chr3:183356904(+) A-I      intronic chr3:183356901(+) A-I      intronic chr3:183356837(+) A-I      intronic chr3:183356803(+) A-I      intronic chr3:183356774(+) A-I      intronic chr3:183355709(+) A-I      intronic chr3:183365395(+) A-I      intronic chr3:183365706(+) A-I      intronic chr3:183366637(+) A-I      intronic chr3:183366639(+) A-I      intronic chr3:183367609(+) A-I      intronic chr3:183367623(+) A-I      intronic chr3:183369535(+) A-I      intronic chr3:183369541(+) A-I      intronic chr3:183373151(+) A-I      intronic chr3:183373153(+) A-I      intronic chr3:183373918(+) A-I      intronic chr3:183373961(+) A-I      intronic chr3:183364672(+) A-I      intronic chr3:183374052(+) A-I      intronic chr3:183374079(+) A-I      intronic chr3:183377285(+) A-I      intronic chr3:183355541(+) A-I      intronic chr3:183355459(+) A-I      intronic chr3:183355447(+) A-I      intronic chr3:183395816(+) A-I      intronic chr3:183395815(+) A-I      intronic chr3:183395683(+) A-I      intronic chr3:183395649(+) A-I      intronic chr3:183387974(+) A-I      intronic chr3:183395643(+) A-I      intronic chr3:183394084(+) A-I      intronic chr3:183394058(+) A-I      intronic chr3:183355576(+) A-I      intronic chr3:183356878(+) A-I      intronic chr3:183361903(+) A-I      intronic chr3:183365356(+) A-I      intronic chr3:183365246(+) A-I      intronic chr3:183364975(+) A-I      intronic chr3:183364727(+) A-I      intronic chr3:183364723(+) A-I      intronic chr3:183364702(+) A-I      intronic chr3:183394050(+) A-I      intronic chr3:183363964(+) A-I      intronic chr3:183363948(+) A-I      intronic chr3:183363924(+) A-I      intronic chr3:183361972(+) A-I      intronic chr3:183361955(+) A-I      intronic chr3:183361954(+) A-I      intronic chr3:183361893(+) A-I      intronic chr3:183359221(+) A-I      intronic chr3:183394045(+) A-I      intronic chr3:183359066(+) A-I      intronic chr3:183359072(+) A-I      intronic chr3:183359094(+) A-I      intronic chr3:183359095(+) A-I      intronic chr3:183359125(+) A-I      intronic chr3:183365616(+) A-I      intronic chr3:183385043(+) A-I      intronic chr3:183385045(+) A-I      intronic chr3:183385065(+) A-I      intronic chr3:183395641(+) A-I      intronic chr3:183395660(+) A-I      intronic chr3:183394025(+) A-I      intronic chr3:183394009(+) A-I      intronic chr3:183392410(+) A-I      intronic chr3:183392408(+) A-I      intronic chr3:183392371(+) A-I      intronic chr3:183392370(+) A-I      intronic chr3:183392359(+) A-I      intronic chr3:183392350(+) A-I      intronic chr3:183359218(+) A-I      intronic chr3:183359191(+) A-I      intronic chr3:183359187(+) A-I      intronic chr3:183392324(+) A-I      intronic chr3:183390925(+) A-I      intronic chr3:183387955(+) A-I      intronic chr3:183387938(+) A-I      intronic chr3:183387785(+) A-I      intronic chr3:183387783(+) A-I      intronic chr3:183387776(+) A-I      intronic chr3:183385605(+) A-I      intronic chr3:183384312(+) A-I      intronic chr3:183384311(+) A-I      intronic chr3:183384081(+) A-I      intronic chr3:183383916(+) A-I      intronic chr3:183383361(+) A-I      intronic chr3:183383284(+) A-I      intronic chr3:183383283(+) A-I      intronic chr3:183377308(+) A-I      intronic chr3:183377299(+) A-I      intronic chr3:183358570(+) A-I      intronic chr3:183385528(+) A-I      intronic chr3:183359186(+) A-I      intronic chr3:183359151(+) A-I      intronic chr3:183360898(+) A-I      ncRNA chr3:183365601(+) A-I      intronic chr3:183385775(+) A-I      intronic chr3:183356782(+) A-I      intronic chr3:183392179(+) A-I      intronic chr3:183385022(+) A-I      intronic chr3:183377968(+) A-I      intronic chr3:183364064(+) A-I      intronic chr3:183373324(+) A-I      intronic chr3:183393482(+) A-I      intronic chr3:183373525(+) A-I      intronic chr3:183385146(+) A-I      intronic chr3:183392248(+) A-I      intronic chr3:183383943(+) A-I      intronic chr3:183355449(+) A-I      intronic chr3:183356495(+) A-I      intronic chr3:183393483(+) A-I      intronic chr3:183365018(+) A-I      intronic chr3:183365097(+) A-I      intronic chr3:183357610(+) A-I      intronic chr3:183392288(+) A-I      intronic chr3:183356734(+) A-I      intronic chr3:183356498(+) A-I      intronic chr3:183355661(+) A-I      intronic chr3:183364003(+) A-I      intronic chr3:183365605(+) A-I      intronic chr3:183385030(+) A-I      intronic chr3:183387920(+) A-I      intronic chr3:183385083(+) A-I      intronic chr3:183364029(+) A-I      intronic chr3:183394146(+) A-I      intronic chr3:183384180(+) A-I      intronic chr3:183383427(+) A-I      intronic chr3:183356787(+) A-I      intronic chr3:183365674(+) A-I      intronic chr3:183359028(+) A-I      intronic chr3:183359175(+) A-I      intronic chr3:183386608(+) A-I      intronic chr3:183366638(+) A-I      intronic chr3:183355627(+) A-I      intronic chr3:183385007(+) A-I      intronic chr3:183364937(+) A-I      intronic chr3:183383708(+) A-I      intronic chr3:183392336(+) A-I      intronic chr3:183358462(+) A-I      intronic chr3:183385563(+) A-I      intronic chr3:183365083(+) A-I      intronic chr3:183384953(+) A-I      intronic chr3:183392228(+) A-I      intronic chr3:183364962(+) A-I      intronic chr3:183384103(+) A-I      intronic chr3:183390873(+) A-I      intronic chr3:183381733(+) A-I      intronic chr3:183373954(+) A-I      intronic chr3:183365553(+) A-I      intronic chr3:183357666(+) A-I      intronic chr3:183392422(+) A-I      intronic chr3:183374003(+) A-I      intronic chr3:183385089(+) A-I      intronic chr3:183365057(+) A-I      intronic chr3:183355612(+) A-I      intronic chr3:183384946(+) A-I      intronic chr3:183359145(+) A-I      intronic chr3:183364059(+) A-I      intronic chr3:183385617(+) A-I      intronic chr3:183363898(+) A-I      intronic chr3:183374085(+) A-I      intronic chr3:183376783(+) A-I      intronic chr3:183384069(+) A-I      intronic chr3:183375815(+) A-I      intronic chr3:183358650(+) A-I      intronic chr3:183392330(+) A-I      intronic chr3:183365378(+) A-I      intronic chr3:183373213(+) A-I      intronic chr3:183364737(+) A-I      intronic chr3:183392249(+) A-I      intronic chr3:183355630(+) A-I      intronic chr3:183376681(+) A-I      intronic chr3:183387973(+) A-I      intronic chr3:183358517(+) A-I      intronic chr3:183358576(+) A-I      intronic chr3:183376733(+) A-I      intronic chr3:183365462(+) A-I      intronic chr3:183356978(+) A-I      intronic chr3:183365647(+) A-I      intronic chr3:183383387(+) A-I      intronic chr3:183365590(+) A-I      intronic chr3:183379002(+) A-I      intronic chr3:183357692(+) A-I      intronic chr3:183361984(+) A-I      intronic chr3:183384127(+) A-I      intronic chr3:183377167(+) A-I      intronic chr3:183373146(+) A-I      intronic chr3:183377139(+) A-I      intronic chr3:183392192(+) A-I      intronic chr3:183356868(+) A-I      intronic chr3:183365673(+) A-I      intronic chr3:183364806(+) A-I      intronic chr3:183369583(+) A-I      intronic chr3:183373950(+) A-I      intronic chr3:183377205(+) A-I      intronic chr3:183388013(+) A-I      intronic chr3:183381746(+) A-I      intronic chr3:183384163(+) A-I      intronic chr3:183364860(+) A-I      intronic chr3:183357679(+) A-I      intronic chr3:183385156(+) A-I      intronic chr3:183364976(+) A-I      intronic chr3:183356998(+) A-I      intronic chr3:183359155(+) A-I      intronic chr3:183373924(+) A-I      intronic chr3:183376641(+) A-I      intronic chr3:183393495(+) A-I      intronic chr3:183356858(+) A-I      intronic chr3:183375881(+) A-I      intronic chr3:183374078(+) A-I      intronic chr3:183365744(+) A-I      intronic chr3:183384151(+) A-I      intronic chr3:183365781(+) A-I      intronic chr3:183387968(+) A-I      intronic chr3:183377148(+) A-I      intronic chr3:183359105(+) A-I      intronic chr3:183384997(+) A-I      intronic chr3:183359097(+) A-I      intronic chr3:183365537(+) A-I      intronic chr3:183365017(+) A-I      intronic chr3:183376731(+) A-I      intronic chr3:183355669(+) A-I      intronic chr3:183365559(+) A-I      intronic chr3:183390886(+) A-I      intronic chr3:183378108(+) A-I      intronic chr3:183366743(+) A-I      intronic chr3:183365093(+) A-I      intronic chr3:183358468(+) A-I      intronic chr3:183383854(+) A-I      intronic chr3:183359104(+) A-I      intronic chr3:183376667(+) A-I      intronic chr3:183359269(+) A-I      intronic chr3:183360963(+) A-I      ncRNA chr3:183360859(+) A-I      ncRNA chr3:183361019(+) A-I      ncRNA chr3:183360891(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KLHL24	chr3:183384946(+) A-I intron -    15545495 chr3:183384953(+) A-I intron -    15545495 chr3:183384974(+) A-I intron -    15545495 chr3:183384997(+) A-I intron -    15545495 chr3:183385007(+) A-I intron -    15545495 chr3:183385022(+) A-I intron -    15545495 chr3:183385030(+) A-I intron -    15545495 chr3:183385083(+) A-I intron -    15545495 chr3:183385089(+) A-I intron -    15545495 chr3:183385093(+) A-I intron -    15545495 chr3:183355451(+) A-I intron -    21960545 chr3:183359066(+) A-I intron -    21960545 chr3:183371647(+) A-I intron -    21960545 chr3:183373146(+) A-I intron -    21960545 chr3:183373153(+) A-I intron -    21960545 chr3:183384151(+) A-I intron -    21960545 chr3:183384185(+) A-I intron -    21960545 chr3:183384509(+) A-I intron -    21960545 chr3:183385634(+) A-I intron -    21960545 chr3:183385639(+) A-I intron -    21960545 chr3:183355451(+) A-G intron -    22484847 chr3:183355516(+) A-G intron -    22484847 chr3:183358462(+) A-G intron -    22484847 chr3:183358640(+) A-G intron -    22484847 chr3:183358650(+) A-G intron -    22484847 chr3:183359145(+) A-G intron -    22484847 chr3:183361885(+) A-G intron -    22484847 chr3:183364737(+) A-G intron -    22484847 chr3:183365028(+) A-G intron -    22484847 chr3:183376783(+) A-G intron -    22484847 chr3:183381746(+) A-G intron -    22484847 chr3:183392248(+) A-G intron -    22484847 chr3:183392249(+) A-G intron -    22484847 chr3:183395722(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLHL24	chr3:183353429-183353430(+) m6A 5'UTR//exon       24981863 chr3:183353489-183353490(+) m6A 5'UTR//exon       - chr3:183353558-183353559(+) m6A 5'UTR//exon//intron       - chr3:183353577-183353578(+) m6A 5'UTR//exon//intron       - chr3:183368167-183368168(+) m6A CDS//intron       24284625//24981863//22608085 chr3:183368172-183368173(+) m6A CDS//intron       24284625//24981863//22608085 chr3:183368232-183368233(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr3:183368295-183368296(+) m6A CDS//intron       24284625//24981863//22608085 chr3:183368567-183368568(+) m6A CDS//intron       24284625//22608085 chr3:183368687-183368688(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr3:183368723-183368724(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr3:183368776-183368777(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr3:183368803-183368804(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr3:183368878-183368879(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr3:183368911-183368912(+) m6A CDS//intron       24284625//24981863//22608085 chr3:183368945-183368946(+) m6A CDS//intron       24981863//22608085 chr3:183368958-183368959(+) m6A CDS//intron       24981863//22608085 chr3:183390104-183390105(+) m6A CDS//exon       24284625 chr3:183390171-183390172(+) m6A CDS//exon       24284625//24981863//22608085 chr3:183390196-183390197(+) m6A CDS//exon       24284625//24981863//22608085 chr3:183390316-183390317(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr3:183390759-183390760(+) m6A 3'UTR//intron       22608085 chr3:183390773-183390774(+) m6A 3'UTR//intron       24209618//22608085 chr3:183396877-183396878(+) m6A CDS       24209618//22608085 chr3:183396949-183396950(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr3:183397067-183397068(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:183397076-183397077(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr3:183397129-183397130(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr3:183397143-183397144(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr3:183397229-183397230(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	KLHL24	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: KLHL24

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.