Detail Information

Basic Information:


  VIRBase ID:  

VHID00375732

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:           ESF1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART18-5p ESF1
miRBase
Accession/Entrez ID		 MIMAT0003717 51575
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - ABTAP//bA526K24.1//C20orf6//HDCMC28P

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ESF1
chr20:13751283(-) A-I      intronic
chr20:13745758(-) A-I      intronic
chr20:13732425(-) A-I      intronic
chr20:13731609(-) A-I      intronic
chr20:13731546(-) A-I      intronic
chr20:13731148(-) A-I      intronic
chr20:13731069(-) A-I      intronic
chr20:13731040(-) A-I      intronic
chr20:13730964(-) A-I      intronic
chr20:13730373(-) A-I      intronic
chr20:13730369(-) A-I      intronic
chr20:13730351(-) A-I      intronic
chr20:13730345(-) A-I      intronic
chr20:13730341(-) A-I      intronic
chr20:13728186(-) A-I      intronic
chr20:13728126(-) A-I      intronic
chr20:13727973(-) A-I      intronic
chr20:13727963(-) A-I      intronic
chr20:13745787(-) A-I      intronic
chr20:13726858(-) A-I      intronic
chr20:13726854(-) A-I      intronic
chr20:13726768(-) A-I      intronic
chr20:13726394(-) A-I      intronic
chr20:13726366(-) A-I      intronic
chr20:13726239(-) A-I      intronic
chr20:13722793(-) A-I      intronic
chr20:13718407(-) A-I      intronic
chr20:13713710(-) A-I      intronic
chr20:13713687(-) A-I      intronic
chr20:13710924(-) A-I      intronic
chr20:13760335(-) A-I      intronic
chr20:13710884(-) A-I      intronic
chr20:13704770(-) A-I      intronic
chr20:13704750(-) A-I      intronic
chr20:13697804(-) A-I      intronic
chr20:13727951(-) A-I      intronic
chr20:13760319(-) A-I      intronic
chr20:13726825(-) A-I      intronic
chr20:13759499(-) A-I      intronic
chr20:13751285(-) A-I      intronic
chr20:13710894(-) A-I      intronic
chr20:13731408(-) A-I      intronic
chr20:13730235(-) A-I      intronic
chr20:13719211(-) A-I      intronic
chr20:13713711(-) A-I      intronic
chr20:13713678(-) A-I      intronic
chr20:13722924(-) A-I      intronic
chr20:13697277(-) A-I      intronic
chr20:13729330(-) A-I      intronic
chr20:13727957(-) A-I      intronic
chr20:13729851(-) A-I      intronic
chr20:13732470(-) A-I      intronic
chr20:13731454(-) A-I      intronic
chr20:13731030(-) A-I      intronic
chr20:13726776(-) A-I      intronic
chr20:13731582(-) A-I      intronic
chr20:13729372(-) A-I      intronic
chr20:13731458(-) A-I      intronic
chr20:13730451(-) A-I      intronic
chr20:13697290(-) A-I      intronic
chr20:13731441(-) A-I      intronic
chr20:13711232(-) A-I      intronic
chr20:13730243(-) A-I      intronic
chr20:13713688(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ESF1
chr20:13695464(-) A-I exon 3'UTR    15342557

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ESF1
chr20:13695043-13695044(-) m6A 3'UTR       27773535
chr20:13695398-13695399(-) m6A 3'UTR       24981863//27773535//22608085
chr20:13695421-13695422(-) m6A 3'UTR       24981863//27773535//22608085
chr20:13695440-13695441(-) m6A 3'UTR       24981863//27773535//22608085
chr20:13695498-13695499(-) m6A 3'UTR       24981863//27773535//22608085
chr20:13695561-13695562(-) m6A CDS       24981863//27773535//27371828//22608085
chr20:13695567-13695568(-) m6A CDS       25456834//24981863//27773535//27371828//22608085
chr20:13695667-13695668(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr20:13695673-13695674(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr20:13695729-13695730(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr20:13695755-13695756(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr20:13698113-13698114(-) m6A CDS       24981863//27773535//22575960//22608085
chr20:13698123-13698124(-) m6A CDS       24981863//27773535//22575960//22608085
chr20:13699560-13699561(-) m6A CDS       24981863//27773535//22608085
chr20:13709031-13709032(-) m6A CDS       24981863//27773535
chr20:13709082-13709083(-) m6A CDS       24981863//27773535
chr20:13714373-13714374(-) m6A CDS       24981863//27773535//22608085
chr20:13714385-13714386(-) m6A CDS       24981863//27773535//22608085
chr20:13714402-13714403(-) m1A CDS       26863196
chr20:13714418-13714419(-) m6A CDS       24981863//27773535//22608085
chr20:13714433-13714434(-) m6A CDS       24981863//27773535//22608085
chr20:13714455-13714456(-) m6A CDS       24981863//27773535//22608085
chr20:13740435-13740436(-) m6A CDS       24981863//27773535//22608085
chr20:13740464-13740465(-) m6A CDS       24981863//27773535//22608085
chr20:13740475-13740476(-) m1A CDS       26863196
chr20:13747491-13747492(-) m6A CDS       24981863//27773535//22608085
chr20:13747549-13747550(-) m6A CDS       24981863//27773535
chr20:13750560-13750561(-) m6A CDS       27773535
chr20:13754395-13754396(-) Gm intron       16381836
chr20:13754396-13754397(-) Gm intron       16381836
chr20:13755832-13755833(-) m6A CDS       27773535
chr20:13755884-13755885(-) m6A CDS       27773535
chr20:13756622-13756623(-) m6A CDS       24981863//27773535//22575960//22608085
chr20:13756873-13756874(-) m6A CDS       24981863//27773535//22608085
chr20:13756891-13756892(-) m6A CDS       24284625//24981863//27773535//22608085
chr20:13763170-13763171(-) m6A 5'UTR//CDS       24284625//24981863//27773535//22608085
chr20:13763220-13763221(-) m6A 5'UTR//CDS       24284625//24981863//27773535//22608085
chr20:13763227-13763228(-) m6A 5'UTR//CDS       24284625//24981863//27773535//22608085
chr20:13763234-13763235(-) m6A 5'UTR//CDS       24284625//24981863//27773535//22608085
chr20:13763253-13763254(-) m6A CDS       24284625//24981863//27773535//22608085
chr20:13763274-13763275(-) m6A CDS       24284625//24981863//27773535//22608085
chr20:13763334-13763335(-) m6A CDS       24284625//24981863//27773535//22608085
chr20:13763362-13763363(-) m6A CDS       24284625//24981863//27773535//22608085
chr20:13763401-13763402(-) m6A CDS       24981863//27773535//22608085
chr20:13763437-13763438(-) m6A CDS       24981863//27773535//22608085
chr20:13763485-13763486(-) m6A CDS       24981863//27773535//22608085
chr20:13763491-13763492(-) m6A CDS       24981863//27773535//22608085
chr20:13763637-13763638(-) m6A CDS       24981863//27773535//22608085
chr20:13763730-13763731(-) m6A CDS       24981863//22608085
chr20:13763774-13763775(-) m6A CDS       24981863//22608085
chr20:13765510-13765511(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ESF1
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART18-5p
Interactor2: ESF1

Evidence Support:


Strong-Evidence RT-PCR//Western blot
Support Database VIRmiRNA

References:


PMID 25012295 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line BL2 cells//BJAB cells Interactor2 expression None
Description BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.

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