Detail Information

Basic Information:


  VIRBase ID:  

VHID00375676

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:           ADIPOR1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART18-5p ADIPOR1
miRBase
Accession/Entrez ID		 MIMAT0003717 51094
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - ACDCR1//CGI-45//CGI45//PAQR1//TESBP1A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ADIPOR1
chr1:202919485(-) A-I      intronic
chr1:202919229(-) A-I      intronic
chr1:202918107(-) A-I      intronic
chr1:202919529(-) A-I      intronic
chr1:202919228(-) A-I      intronic
chr1:202918047(-) A-I      intronic
chr1:202918083(-) A-I      intronic
chr1:202918596(-) A-I      intronic
chr1:202918626(-) A-I      intronic
chr1:202919176(-) A-I      intronic
chr1:202919491(-) A-I      intronic
chr1:202919239(-) A-I      intronic
chr1:202919457(-) A-I      intronic
chr1:202919337(-) A-I      intronic
chr1:202919439(-) A-I      intronic
chr1:202919530(-) A-I      intronic
chr1:202918017(-) A-I      intronic
chr1:202918079(-) A-I      intronic
chr1:202919484(-) A-I      intronic
chr1:202918112(-) A-I      intronic
chr1:202919349(-) A-I      intronic
chr1:202919355(-) A-I      intronic
chr1:202918056(-) A-I      intronic
chr1:202918089(-) A-I      intronic
chr1:202918452(-) A-I      intronic
chr1:202919129(-) A-I      intronic
chr1:202918123(-) A-I      intronic
chr1:202918827(-) A-I      intronic
chr1:202917987(-) A-I      intronic
chr1:202918209(-) A-I      intronic
chr1:202917991(-) A-I      intronic
chr1:202919445(-) A-I      intronic
chr1:202919364(-) A-I      intronic
chr1:202919467(-) A-I      intronic
chr1:202918016(-) A-I      intronic
chr1:202919458(-) A-I      intronic
chr1:202917980(-) A-I      intronic
chr1:202918665(-) A-I      intronic
chr1:202918608(-) A-I      intronic
chr1:202919290(-) A-I      intronic
chr1:202918191(-) A-I      intronic
chr1:202919443(-) A-I      intronic
chr1:202918122(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ADIPOR1
chr1:202912012(-) C-A intron -    22484847
chr1:202916556(-) T-A intron -    22484847
chr1:202918017(-) A-G intron -    22484847
chr1:202918056(-) A-G intron -    22484847
chr1:202918079(-) A-G intron -    22484847
chr1:202918122(-) A-G intron -    22484847
chr1:202918123(-) A-G intron -    22484847
chr1:202918191(-) A-G intron -    22484847
chr1:202918608(-) A-G intron -    22484847
chr1:202918665(-) A-G intron -    22484847
chr1:202919290(-) A-G intron -    22484847
chr1:202919349(-) A-G intron -    22484847
chr1:202919355(-) A-G intron -    22484847
chr1:202919364(-) A-G intron -    22484847
chr1:202919467(-) A-G intron -    22484847
chr1:202919484(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADIPOR1
chr1:202909974-202909975(-) m6A 3'UTR//exon       27773535
chr1:202910005-202910006(-) m6A 3'UTR//exon       27773535
chr1:202910039-202910040(-) m6A 3'UTR//exon       27773535
chr1:202910254-202910255(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960
chr1:202910371-202910372(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr1:202910377-202910378(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr1:202910428-202910429(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr1:202910441-202910442(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr1:202910489-202910490(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr1:202910533-202910534(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr1:202910595-202910596(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr1:202910671-202910672(-) m6A 3'UTR//exon       27773535
chr1:202911332-202911333(-) m6A 3'UTR//CDS//exon       27773535//22575960
chr1:202912894-202912895(-) m6A 3'UTR//CDS//exon       27773535//22575960
chr1:202912923-202912924(-) m6A CDS//exon       27773535//22575960
chr1:202914120-202914121(-) m6A CDS//intron       27773535
chr1:202914253-202914254(-) m6A CDS//intron       27773535
chr1:202915578-202915579(-) m6A CDS       27773535
chr1:202915593-202915594(-) m6A CDS       27773535
chr1:202915651-202915652(-) m6A CDS       27773535
chr1:202915679-202915680(-) m6A CDS       27773535
chr1:202917532-202917533(-) m6A CDS       24981863//28052920//27773535//27371828//27773536//22575960
chr1:202920097-202920098(-) Tm CDS       -
chr1:202920105-202920106(-) m6A CDS       24981863//27773535//27371828//27773536//22575960
chr1:202920111-202920112(-) m6A CDS       24981863//27773535//27371828//27773536//22575960
chr1:202920120-202920121(-) m6A CDS       24981863//27773535//27371828//27773536//22575960
chr1:202920248-202920249(-) m6A 5'UTR       27773535//27773536
chr1:202923409-202923410(-) m6A 5'UTR//intron       27773536
chr1:202923416-202923417(-) m6A 5'UTR//intron       27773536
chr1:202923421-202923422(-) m6A 5'UTR//intron       27773536
chr1:202923426-202923427(-) m6A 5'UTR//intron       27773536
chr1:202927345-202927346(-) m6A 5'UTR//intron       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ADIPOR1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART18-5p
Interactor2: ADIPOR1

Evidence Support:


Strong-Evidence RT-PCR//Western blot
Weak-Evidence Microarray
Prediction-Evidence miRanda//Targetscan
Support Database VIRmiRNA//VmiReg

References:


PMID 25012295 Target region 3'UTR
Source VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BL2 cells//BJAB cells Interactor2 expression None
Description BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.

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