Detail Information

Basic Information:


  VIRBase ID:  

VHID00375632

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:           STRN4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART18-5p STRN4
miRBase
Accession/Entrez ID		 MIMAT0003717 29888
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - PPP2R6C//ZIN//zinedin

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STRN4
chr19:47247855(-) A-I      intronic
chr19:47247845(-) A-I      intronic
chr19:47246039(-) A-I      intronic
chr19:47245993(-) A-I      intronic
chr19:47247809(-) A-I      intronic
chr19:47245952(-) A-I      intronic
chr19:47245948(-) A-I      intronic
chr19:47245916(-) A-I      intronic
chr19:47247779(-) A-I      intronic
chr19:47238193(-) A-I      intronic
chr19:47238116(-) A-I      intronic
chr19:47238090(-) A-I      intronic
chr19:47245931(-) A-I      intronic
chr19:47246069(-) A-I      intronic
chr19:47246085(-) A-I      intronic
chr19:47246894(-) A-I      intronic
chr19:47247810(-) A-I      intronic
chr19:47247869(-) A-I      intronic
chr19:47238306(-) A-I      intronic
chr19:47243361(-) A-I      intronic
chr19:47243477(-) A-I      5'UTR
chr19:47243434(-) A-I      5'UTR
chr19:47239410(-) A-I      intronic
chr19:47238163(-) A-I      intronic
chr19:47238406(-) A-I      intronic
chr19:47239432(-) A-I      intronic
chr19:47247674(-) A-I      intronic
chr19:47238476(-) A-I      intronic
chr19:47238126(-) A-I      intronic
chr19:47246015(-) A-I      intronic
chr19:47247908(-) A-I      intronic
chr19:47238194(-) A-I      intronic
chr19:47247843(-) A-I      intronic
chr19:47247874(-) A-I      intronic
chr19:47238370(-) A-I      intronic
chr19:47238225(-) A-I      intronic
chr19:47237957(-) A-I      intronic
chr19:47239384(-) A-I      intronic
chr19:47238356(-) A-I      intronic
chr19:47238119(-) A-I      intronic
chr19:47238147(-) A-I      intronic
chr19:47246912(-) A-I      intronic
chr19:47238318(-) A-I      intronic
chr19:47238451(-) A-I      intronic
chr19:47238391(-) A-I      intronic
chr19:47247713(-) A-I      intronic
chr19:47238396(-) A-I      intronic
chr19:47238293(-) A-I      intronic
chr19:47238210(-) A-I      intronic
chr19:47246939(-) A-I      intronic
chr19:47238019(-) A-I      intronic
chr19:47238054(-) A-I      intronic
chr19:47243352(-) A-I      intronic
chr19:47246991(-) A-I      intronic
chr19:47238018(-) A-I      intronic
chr19:47246900(-) A-I      intronic
chr19:47238060(-) A-I      intronic
chr19:47238319(-) A-I      intronic
chr19:47247824(-) A-I      intronic
chr19:47238033(-) A-I      intronic
chr19:47238096(-) A-I      intronic
chr19:47238415(-) A-I      intronic
chr19:47239383(-) A-I      intronic
chr19:47246994(-) A-I      intronic
chr19:47238455(-) A-I      intronic
chr19:47238441(-) A-I      intronic
chr19:47239351(-) A-I      intronic
chr19:47238480(-) A-I      intronic
chr19:47243483(-) A-I      5'UTR
chr19:47245825(-) A-I      intronic
chr19:47246952(-) A-I      intronic
chr19:47246937(-) A-I      intronic
chr19:47238506(-) A-I      intronic
chr19:47245999(-) A-I      intronic
chr19:47245880(-) A-I      intronic
chr19:47238207(-) A-I      intronic
chr19:47246014(-) A-I      intronic
chr19:47239365(-) A-I      intronic
chr19:47243424(-) A-I      5'UTR
chr19:47246090(-) A-I      intronic
chr19:47239482(-) A-I      intronic
chr19:47238383(-) A-I      intronic
chr19:47238150(-) A-I      intronic
chr19:47243470(-) A-I      5'UTR
chr19:47247821(-) A-I      intronic
chr19:47247060(-) A-I      intronic
chr19:47247676(-) A-I      intronic
chr19:47238380(-) A-I      intronic
chr19:47246091(-) A-I      intronic
chr19:47247915(-) A-I      intronic
chr19:47243446(-) A-I      5'UTR
chr19:47247738(-) A-I      intronic
chr19:47243463(-) A-I      5'UTR
chr19:47247737(-) A-I      intronic
chr19:47247077(-) A-I      intronic
chr19:47247138(-) A-I      intronic
chr19:47238105(-) A-I      intronic
chr19:47246913(-) A-I      intronic
chr19:47238118(-) A-I      intronic
chr19:47247048(-) A-I      intronic
chr19:47247765(-) A-I      intronic
chr19:47246891(-) A-I      intronic
chr19:47238099(-) A-I      intronic
chr19:47243381(-) A-I      intronic
chr19:47247739(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STRN4
chr19:47225529(-) A-I exon CDS    19478186
chr19:47237957(-) A-I intron -    22028664
chr19:47238018(-) A-I intron -    22028664
chr19:47238019(-) A-I intron -    22028664
chr19:47238033(-) A-I intron -    22028664
chr19:47238054(-) A-I intron -    22028664
chr19:47238060(-) A-I intron -    22028664
chr19:47238086(-) A-I intron -    22028664
chr19:47238096(-) A-I intron -    22028664
chr19:47238118(-) A-I intron -    22028664
chr19:47238119(-) A-I intron -    22028664
chr19:47238126(-) A-I intron -    22028664
chr19:47238147(-) A-I intron -    22028664
chr19:47238150(-) A-I intron -    22028664
chr19:47238163(-) A-I intron -    22028664
chr19:47238194(-) A-I intron -    22028664
chr19:47238207(-) A-I intron -    22028664
chr19:47238210(-) A-I intron -    22028664
chr19:47238225(-) A-I intron -    22028664
chr19:47238262(-) A-I intron -    22028664
chr19:47238293(-) A-I intron -    22028664
chr19:47238318(-) A-I intron -    22028664
chr19:47238319(-) A-I intron -    22028664
chr19:47238337(-) A-I intron -    22028664
chr19:47238356(-) A-I intron -    22028664
chr19:47238370(-) A-I intron -    22028664
chr19:47238380(-) A-I intron -    22028664
chr19:47238383(-) A-I intron -    22028664
chr19:47238391(-) A-I intron -    22028664
chr19:47238397(-) A-I intron -    22028664
chr19:47238406(-) A-I intron -    22028664
chr19:47238415(-) A-I intron -    22028664
chr19:47238441(-) A-I intron -    22028664
chr19:47238451(-) A-I intron -    22028664
chr19:47238455(-) A-I intron -    22028664
chr19:47238476(-) A-I intron -    22028664
chr19:47237957(-) A-G intron -    22484847
chr19:47238105(-) A-G intron -    22484847
chr19:47238207(-) A-G intron -    22484847
chr19:47238380(-) A-G intron -    22484847
chr19:47238383(-) A-G intron -    22484847
chr19:47238397(-) A-G intron -    22484847
chr19:47246994(-) A-G intron -    22484847
chr19:47247811(-) A-G intron -    22484847
chr19:47247841(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STRN4
chr19:47222780-47222781(-) m6A 3'UTR//exon       24981863//27773535
chr19:47222794-47222795(-) m6A 3'UTR//exon       24981863//27773535
chr19:47223007-47223008(-) m6A 3'UTR//exon       24284625//27773535
chr19:47223260-47223261(-) m6A 3'UTR//exon       27773535
chr19:47223321-47223322(-) m6A 3'UTR//exon       27773535
chr19:47223994-47223995(-) m6A CDS//exon       27773535
chr19:47224109-47224110(-) m6A exon//intron       27371828
chr19:47224198-47224199(-) m6A exon//intron       -
chr19:47224208-47224209(-) m6A exon//intron       -
chr19:47224215-47224216(-) m6A exon//intron       -
chr19:47225560-47225561(-) m6A CDS//exon       27773536
chr19:47228867-47228868(-) m6A 3'UTR//CDS//exon       27773535
chr19:47228932-47228933(-) m6A exon//intron       27773535
chr19:47230754-47230755(-) m6A 3'UTR//CDS//exon       27773535
chr19:47230787-47230788(-) m6A 3'UTR//CDS//exon       27773535
chr19:47231247-47231248(-) m6A 3'UTR//CDS//exon       -
chr19:47231302-47231303(-) m6A CDS//exon//intron       -
chr19:47231313-47231314(-) m6A CDS//exon//intron       -
chr19:47231915-47231916(-) m6A CDS//exon       24209618//25456834//27773535//27371828
chr19:47234019-47234020(-) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//27371828//27773536//22575960
chr19:47234043-47234044(-) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//27371828//27773536//22575960
chr19:47234058-47234059(-) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//27371828//27773536//22575960
chr19:47234163-47234164(-) m6A exon//intron       24209618//24981863//27773535//27371828//27773536
chr19:47235027-47235028(-) m6A exon//intron       24209618//27371828
chr19:47236317-47236318(-) Cm 3'UTR//CDS//exon       -
chr19:47236318-47236319(-) m6A 3'UTR//CDS//exon       24209618//27371828//27773536
chr19:47236466-47236467(-) m6A 3'UTR//CDS//exon       24209618//27371828//27773536
chr19:47240121-47240122(-) m6A CDS//exon       24209618
chr19:47241424-47241425(-) m6A CDS//exon       24209618//22575960
chr19:47241455-47241456(-) m6A CDS//exon       24209618//22575960
chr19:47241465-47241466(-) m6A CDS//exon       24209618//22575960
chr19:47241478-47241479(-) m6A CDS//exon       24209618//22575960
chr19:47242089-47242090(-) m6A 5'UTR//CDS//exon       24209618
chr19:47242577-47242578(-) m6A 5'UTR//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate STRN4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART18-5p
Interactor2: STRN4

Evidence Support:


Strong-Evidence RT-PCR//Western blot
Support Database VIRmiRNA

References:


PMID 25012295 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line BL2 cells//BJAB cells Interactor2 expression None
Description BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.

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