Basic Information:

  VIRBase ID:  

VHID00375564

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          WIPI2:  NM_001033520     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	WIPI2
miRBase Accession/Entrez ID	MIMAT0003717	26100
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATG18B//Atg21//CGI-50//IDDSSA//WIPI-2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WIPI2	chr7:5236587(+) A-I      intronic chr7:5234863(+) A-I      intronic chr7:5234840(+) A-I      intronic chr7:5234380(+) A-I      intronic chr7:5234341(+) A-I      intronic chr7:5234340(+) A-I      intronic chr7:5233461(+) A-I      intronic chr7:5238071(+) A-I      intronic chr7:5238070(+) A-I      intronic chr7:5238048(+) A-I      intronic chr7:5236572(+) A-I      intronic chr7:5238045(+) A-I      intronic chr7:5238907(+) A-I      intronic chr7:5238911(+) A-I      intronic chr7:5241196(+) A-I      intronic chr7:5241103(+) A-I      intronic chr7:5238953(+) A-I      intronic chr7:5238888(+) A-I      intronic chr7:5236671(+) A-I      intronic chr7:5241217(+) A-I      intronic chr7:5241309(+) A-I      intronic chr7:5243453(+) A-I      intronic chr7:5243497(+) A-I      intronic chr7:5243506(+) A-I      intronic chr7:5243516(+) A-I      intronic chr7:5243911(+) A-I      intronic chr7:5243912(+) A-I      intronic chr7:5243959(+) A-I      intronic chr7:5245216(+) A-I      intronic chr7:5245297(+) A-I      intronic chr7:5235614(+) A-I      intronic chr7:5233307(+) A-I      intronic chr7:5238947(+) A-I      intronic chr7:5245400(+) A-I      intronic chr7:5236649(+) A-I      intronic chr7:5263420(+) A-I      intronic chr7:5253523(+) A-I      intronic chr7:5263976(+) A-I      intronic chr7:5235656(+) A-I      intronic chr7:5238772(+) A-I      intronic chr7:5260616(+) A-I      intronic chr7:5238049(+) A-I      intronic chr7:5235585(+) A-I      intronic chr7:5235042(+) A-I      intronic chr7:5237981(+) A-I      intronic chr7:5235603(+) A-I      intronic chr7:5251024(+) A-I      intronic chr7:5244859(+) A-I      intronic chr7:5236515(+) A-I      intronic chr7:5236527(+) A-I      intronic chr7:5234884(+) A-I      intronic chr7:5234879(+) A-I      intronic chr7:5236622(+) A-I      intronic chr7:5235979(+) A-I      intronic chr7:5235762(+) A-I      intronic chr7:5238084(+) A-I      intronic chr7:5238128(+) A-I      intronic chr7:5238677(+) A-I      intronic chr7:5235742(+) A-I      intronic chr7:5235716(+) A-I      intronic chr7:5238074(+) A-I      intronic chr7:5236725(+) A-I      intronic chr7:5233306(+) A-I      intronic chr7:5238197(+) A-I      intronic chr7:5245319(+) A-I      intronic chr7:5252433(+) A-I      intronic chr7:5243344(+) A-I      intronic chr7:5252315(+) A-I      intronic chr7:5245322(+) A-I      intronic chr7:5235550(+) A-I      intronic chr7:5236616(+) A-I      intronic chr7:5252358(+) A-I      intronic chr7:5252277(+) A-I      intronic chr7:5238908(+) A-I      intronic chr7:5238759(+) A-I      intronic chr7:5234885(+) A-I      intronic chr7:5243951(+) A-I      intronic chr7:5252332(+) A-I      intronic chr7:5243439(+) A-I      intronic chr7:5235452(+) A-I      intronic chr7:5235006(+) A-I      intronic chr7:5253397(+) A-I      intronic chr7:5238709(+) A-I      intronic chr7:5238038(+) A-I      intronic chr7:5235417(+) A-I      intronic chr7:5236668(+) A-I      intronic chr7:5238760(+) A-I      intronic chr7:5235591(+) A-I      intronic chr7:5236632(+) A-I      intronic chr7:5233276(+) A-I      intronic chr7:5241188(+) A-I      intronic chr7:5238165(+) A-I      intronic chr7:5235651(+) A-I      intronic chr7:5234328(+) A-I      intronic chr7:5252250(+) A-I      intronic chr7:5252188(+) A-I      intronic chr7:5260329(+) A-I      intronic chr7:5244869(+) A-I      intronic chr7:5241111(+) A-I      intronic chr7:5234327(+) A-I      intronic chr7:5238806(+) A-I      intronic chr7:5238887(+) A-I      intronic chr7:5244541(+) A-I      intronic chr7:5233415(+) A-I      intronic chr7:5235876(+) A-I      intronic chr7:5243849(+) A-I      intronic chr7:5245341(+) A-I      intronic chr7:5244746(+) A-I      intronic chr7:5235549(+) A-I      intronic chr7:5238724(+) A-I      intronic chr7:5234281(+) A-I      intronic chr7:5235483(+) A-I      intronic chr7:5241189(+) A-I      intronic chr7:5252384(+) A-I      intronic chr7:5235892(+) A-I      intronic chr7:5250847(+) A-I      intronic chr7:5236663(+) A-I      intronic chr7:5254686(+) A-I      intronic chr7:5238856(+) A-I      intronic chr7:5245230(+) A-I      intronic chr7:5238180(+) A-I      intronic chr7:5236664(+) A-I      intronic chr7:5235866(+) A-I      intronic chr7:5250848(+) A-I      intronic chr7:5235523(+) A-I      intronic chr7:5252251(+) A-I      intronic chr7:5236628(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WIPI2	chr7:5234281(+) A-I intron -    21960545 chr7:5258862(+) C-T intron -    22484847 chr7:5234281(+) A-G intron -    22484847 chr7:5234326(+) A-G intron -    22484847 chr7:5234327(+) A-G intron -    22484847 chr7:5234328(+) A-G intron -    22484847 chr7:5235006(+) A-G intron -    22484847 chr7:5235443(+) A-G intron -    22484847 chr7:5235467(+) C-T intron -    22484847 chr7:5235483(+) A-G intron -    22484847 chr7:5235549(+) A-G intron -    22484847 chr7:5235550(+) A-G intron -    22484847 chr7:5236616(+) A-G intron -    22484847 chr7:5236632(+) A-G intron -    22484847 chr7:5236636(+) A-G intron -    22484847 chr7:5238760(+) A-G intron -    22484847 chr7:5238803(+) A-G intron -    22484847 chr7:5238806(+) A-G intron -    22484847 chr7:5238887(+) A-G intron -    22484847 chr7:5238908(+) A-G intron -    22484847 chr7:5241188(+) A-G intron -    22484847 chr7:5241189(+) A-G intron -    22484847 chr7:5241256(+) A-G intron -    22484847 chr7:5242068(+) A-G intron -    22484847 chr7:5243344(+) A-G intron -    22484847 chr7:5243368(+) A-G intron -    22484847 chr7:5243436(+) A-G intron -    22484847 chr7:5243849(+) A-G intron -    22484847 chr7:5244018(+) G-A intron -    22484847 chr7:5244541(+) A-G intron -    22484847 chr7:5245230(+) A-G intron -    22484847 chr7:5245341(+) A-G intron -    22484847 chr7:5250839(+) A-G intron -    22484847 chr7:5250848(+) A-G intron -    22484847 chr7:5252188(+) A-G intron -    22484847 chr7:5252250(+) A-G intron -    22484847 chr7:5252251(+) A-G intron -    22484847 chr7:5252264(+) A-G intron -    22484847 chr7:5252277(+) A-G intron -    22484847 chr7:5252310(+) A-G intron -    22484847 chr7:5252358(+) A-G intron -    22484847 chr7:5252384(+) A-G intron -    22484847 chr7:5261596(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WIPI2	chr7:5229892-5229893(+) m6A 5'UTR//exon       24209618//25456834//24981863 chr7:5230054-5230055(+) m6A CDS//exon       - chr7:5256734-5256735(+) Y CDS//exon       26075521 chr7:5262373-5262374(+) m6A exon//intron       - chr7:5262386-5262387(+) m6A exon//intron       - chr7:5265523-5265524(+) m6A CDS//exon       - chr7:5265540-5265541(+) m6A CDS//exon       - chr7:5265547-5265548(+) m6A CDS//exon       - chr7:5265600-5265601(+) m6A exon//intron       - chr7:5267799-5267800(+) m6A CDS//exon       24284625 chr7:5269044-5269045(+) m6A exon//intron       24284625 chr7:5269058-5269059(+) m6A exon//intron       24284625 chr7:5269276-5269277(+) m6A CDS//exon       24284625 chr7:5269311-5269312(+) m6A CDS//exon       24284625//22575960 chr7:5269364-5269365(+) m6A CDS//exon//intron       24284625//24209618//25456834//22575960//22608085 chr7:5270540-5270541(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr7:5270569-5270570(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr7:5270578-5270579(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr7:5270613-5270614(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:5270631-5270632(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:5270653-5270654(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:5270687-5270688(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:5270854-5270855(+) m6A 3'UTR//exon       24284625//22608085 chr7:5270973-5270974(+) m6A 3'UTR//exon       24284625 chr7:5271061-5271062(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr7:5271073-5271074(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr7:5271106-5271107(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr7:5271182-5271183(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:5271223-5271224(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr7:5271250-5271251(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr7:5271274-5271275(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr7:5271292-5271293(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr7:5271371-5271372(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5271437-5271438(+) m6A 3'UTR       24981863 chr7:5271708-5271709(+) m6A 3'UTR       24981863//22608085 chr7:5271722-5271723(+) m6A 3'UTR       24981863//22608085 chr7:5271838-5271839(+) m6A 3'UTR       24209618//22608085 chr7:5271874-5271875(+) m6A 3'UTR       24209618 chr7:5272009-5272010(+) m6A 3'UTR       25456834//22608085 chr7:5272122-5272123(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr7:5272136-5272137(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr7:5272155-5272156(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5272193-5272194(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5272202-5272203(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5272316-5272317(+) m6A 3'UTR       24209618//25456834//22608085 chr7:5272399-5272400(+) m6A 3'UTR       24284625//25456834 chr7:5272708-5272709(+) m6A 3'UTR       24284625//24209618//25456834 chr7:5272773-5272774(+) m6A 3'UTR       24284625//24209618//25456834//22608085 chr7:5272902-5272903(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5272935-5272936(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5272956-5272957(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5272987-5272988(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273024-5273025(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273031-5273032(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273036-5273037(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273060-5273061(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273067-5273068(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273107-5273108(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273142-5273143(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273147-5273148(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273177-5273178(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273185-5273186(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273190-5273191(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273209-5273210(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273217-5273218(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273234-5273235(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273251-5273252(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273326-5273327(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:5273339-5273340(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WIPI2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: WIPI2

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.