Basic Information:

  VIRBase ID:  

VHID00375363

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9523

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          RPIA:  NM_144563     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	RPIA
miRBase Accession/Entrez ID	MIMAT0003717	22934
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	RPI//RPIAD

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RPIA	chr2:89015871(+) A-I      intronic chr2:89015872(+) A-I      intronic chr2:89015860(+) A-I      intronic chr2:89015866(+) A-I      intronic chr2:89015819(+) A-I      intronic chr2:89015856(+) A-I      intronic chr2:89008416(+) A-I      intronic chr2:89008420(+) A-I      intronic chr2:89000017(+) A-I      intronic chr2:89000023(+) A-I      intronic chr2:89009584(+) A-I      intronic chr2:89008456(+) A-I      intronic chr2:89009588(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RPIA	chr2:89015734(+) A-G intron -    22484847 chr2:89015737(+) A-G intron -    22484847 chr2:89015854(+) A-G intron -    22484847 chr2:89032276(+) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RPIA	chr2:88991185-88991186(+) m6A 5'UTR       24981863 chr2:88991310-88991311(+) m6A CDS       24981863 chr2:88991319-88991320(+) m6A CDS       24981863 chr2:88991366-88991367(+) m6A CDS       24981863 chr2:88991406-88991407(+) m6A CDS       - chr2:88991490-88991491(+) m6A CDS       - chr2:89049569-89049570(+) m6A CDS       - chr2:89049694-89049695(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RPIA	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: RPIA

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.