Basic Information:

  VIRBase ID:  

VHID00375308

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9616

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          HNRNPUL1:  NM_001301016     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	HNRNPUL1
miRBase Accession/Entrez ID	MIMAT0003717	11100
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	E1B-AP5//E1BAP5//HNRPUL1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HNRNPUL1	chr19:41790324(+) A-I      intronic chr19:41790361(+) A-I      intronic chr19:41781915(+) A-I      intronic chr19:41781887(+) A-I      intronic chr19:41772432(+) A-I      intronic chr19:41772328(+) A-I      intronic chr19:41772323(+) A-I      intronic chr19:41772288(+) A-I      intronic chr19:41774508(+) A-I      intronic chr19:41774509(+) A-I      intronic chr19:41774652(+) A-I      intronic chr19:41775525(+) A-I      intronic chr19:41776626(+) A-I      intronic chr19:41776640(+) A-I      intronic chr19:41781914(+) A-I      intronic chr19:41776140(+) A-I      intronic chr19:41791201(+) A-I      intronic chr19:41772107(+) A-I      intronic chr19:41791211(+) A-I      intronic chr19:41796812(+) A-I      intronic chr19:41797655(+) A-I      intronic chr19:41798862(+) A-I      intronic chr19:41799863(+) A-I      intronic chr19:41776148(+) A-I      intronic chr19:41776149(+) A-I      intronic chr19:41775911(+) A-I      intronic chr19:41776013(+) A-I      intronic chr19:41772137(+) A-I      intronic chr19:41772471(+) A-I      intronic chr19:41775912(+) A-I      intronic chr19:41776005(+) A-I      intronic chr19:41776071(+) A-I      intronic chr19:41776150(+) A-I      intronic chr19:41791206(+) A-I      intronic chr19:41796876(+) A-I      intronic chr19:41772076(+) A-I      intronic chr19:41797702(+) A-I      intronic chr19:41790790(+) A-I      intronic chr19:41797632(+) A-I      intronic chr19:41789544(+) A-I      intronic chr19:41797738(+) A-I      intronic chr19:41775633(+) A-I      intronic chr19:41772398(+) A-I      intronic chr19:41791246(+) A-I      intronic chr19:41776294(+) A-I      intronic chr19:41784013(+) A-I      intronic chr19:41784146(+) A-I      intronic chr19:41797739(+) A-I      intronic chr19:41781358(+) A-I      intronic chr19:41797633(+) A-I      intronic chr19:41789189(+) A-I      intronic chr19:41790740(+) A-I      intronic chr19:41775601(+) A-I      intronic chr19:41790369(+) A-I      intronic chr19:41772156(+) A-I      intronic chr19:41772192(+) A-I      intronic chr19:41790743(+) A-I      intronic chr19:41797407(+) A-I      intronic chr19:41775968(+) A-I      intronic chr19:41793187(+) A-I      intronic chr19:41772191(+) A-I      intronic chr19:41775466(+) A-I      intronic chr19:41790745(+) A-I      intronic chr19:41790337(+) A-I      intronic chr19:41791268(+) A-I      intronic chr19:41797663(+) A-I      intronic chr19:41791294(+) A-I      intronic chr19:41799676(+) A-I      intronic chr19:41775623(+) A-I      intronic chr19:41776601(+) A-I      intronic chr19:41799791(+) A-I      intronic chr19:41774643(+) A-I      intronic chr19:41772068(+) A-I      intronic chr19:41797477(+) A-I      intronic chr19:41790370(+) A-I      intronic chr19:41791802(+) A-I      intronic chr19:41791295(+) A-I      intronic chr19:41788361(+) A-I      intronic chr19:41772349(+) A-I      intronic chr19:41797779(+) A-I      intronic chr19:41791931(+) A-I      intronic chr19:41772063(+) A-I      intronic chr19:41776234(+) A-I      intronic chr19:41782817(+) A-I      intronic chr19:41782801(+) A-I      intronic chr19:41794244(+) A-I      intronic chr19:41793101(+) A-I      intronic chr19:41784064(+) A-I      intronic chr19:41797701(+) A-I      intronic chr19:41797630(+) A-I      intronic chr19:41782776(+) A-I      intronic chr19:41790309(+) A-I      intronic chr19:41793135(+) A-I      intronic chr19:41795783(+) A-I      intronic chr19:41794289(+) A-I      intronic chr19:41799637(+) A-I      intronic chr19:41782726(+) A-I      intronic chr19:41782883(+) A-I      intronic chr19:41776162(+) A-I      intronic chr19:41784018(+) A-I      intronic chr19:41798817(+) A-I      intronic chr19:41791916(+) A-I      intronic chr19:41775988(+) A-I      intronic chr19:41772085(+) A-I      intronic chr19:41775906(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HNRNPUL1	chr19:41772398(+) A-I intron -    21960545 chr19:41791187(+) A-I intron -    21960545 chr19:41791254(+) A-I intron -    21960545 chr19:41772085(+) A-G intron -    22484847 chr19:41772398(+) A-G intron -    22484847 chr19:41775623(+) A-G intron -    22484847 chr19:41775633(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HNRNPUL1	chr19:41768467-41768468(+) m6A 5'UTR       24284625//25456834//24981863 chr19:41768473-41768474(+) m6A 5'UTR       24284625//25456834//24981863 chr19:41768602-41768603(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr19:41768817-41768818(+) m6A 5'UTR//intron       24981863 chr19:41768865-41768866(+) m6A 5'UTR//intron       24981863 chr19:41770354-41770355(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:41770437-41770438(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:41770469-41770470(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:41770566-41770567(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085 chr19:41770603-41770604(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085 chr19:41770630-41770631(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085 chr19:41770698-41770699(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr19:41770848-41770849(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863 chr19:41770901-41770902(+) m6A 5'UTR//intron       25456834//24981863 chr19:41770980-41770981(+) m6A 5'UTR//intron       25456834//24981863 chr19:41770987-41770988(+) m6A 5'UTR//intron       25456834//24981863 chr19:41771019-41771020(+) m6A 5'UTR//exon//intron       25456834//24981863 chr19:41774088-41774089(+) m6A 5'UTR//intron       24209618//24981863 chr19:41774136-41774137(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942 chr19:41774154-41774155(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942 chr19:41774182-41774183(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942 chr19:41774212-41774213(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960 chr19:41777994-41777995(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960 chr19:41778058-41778059(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960 chr19:41778100-41778101(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960 chr19:41778211-41778212(+) m6A exon//intron       - chr19:41787133-41787134(+) m6A 3'UTR//CDS//intron       26404942//22575960 chr19:41787142-41787143(+) m6A 3'UTR//CDS//intron       26404942//22575960 chr19:41798175-41798176(+) m6A 3'UTR//CDS//intron       26404942//22575960 chr19:41798301-41798302(+) m6A 3'UTR//CDS//intron       26404942//22575960 chr19:41798391-41798392(+) m6A 3'UTR//CDS//intron       26404942//22575960 chr19:41800278-41800279(+) m6A 3'UTR//CDS//intron       26404942//22575960 chr19:41800295-41800296(+) m6A 3'UTR//CDS//intron       26404942//22575960 chr19:41800487-41800488(+) m6A 3'UTR//CDS//intron       26404942//22575960 chr19:41807478-41807479(+) m6A 3'UTR//CDS//exon//intron       24981863//26404942 chr19:41807531-41807532(+) m6A 3'UTR//CDS//exon//intron       24209618//24981863//26404942//27773535 chr19:41807540-41807541(+) m6A 3'UTR//CDS//exon//intron       24209618//24981863//26404942//27773535 chr19:41807545-41807546(+) m6A 3'UTR//CDS//exon//intron       24209618//24981863//26404942//27773535 chr19:41807557-41807558(+) m6A 3'UTR//CDS//intron       24209618//24981863//26404942//27773535 chr19:41808345-41808346(+) m6A exon//intron       24209618//26404942//27773535 chr19:41808510-41808511(+) m6A exon//intron       - chr19:41808596-41808597(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//22575960 chr19:41808644-41808645(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//22575960 chr19:41808773-41808774(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960 chr19:41808780-41808781(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960 chr19:41808812-41808813(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960 chr19:41809912-41809913(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//22575960 chr19:41810068-41810069(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//22575960 chr19:41810098-41810099(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960 chr19:41811736-41811737(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942 chr19:41812369-41812370(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960 chr19:41812384-41812385(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960 chr19:41812414-41812415(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960 chr19:41812441-41812442(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960 chr19:41812668-41812669(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:41812862-41812863(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr19:41812939-41812940(+) m6A 3'UTR//exon       24981863//27773535 chr19:41813123-41813124(+) m6A 3'UTR       27773535 chr19:41813128-41813129(+) m6A 3'UTR       27773535 chr19:41813138-41813139(+) m6A 3'UTR       27773535 chr19:41813143-41813144(+) m6A 3'UTR       27773535 chr19:41813364-41813365(+) m6A 3'UTR       24284625//25456834 chr19:41813414-41813415(+) m6A 3'UTR       24284625//25456834 chr19:41813492-41813493(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HNRNPUL1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: HNRNPUL1

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray//PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.