Basic Information:

  VIRBase ID:  

VHID00375305

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          SNRNP35:  NR_104103     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	SNRNP35
miRBase Accession/Entrez ID	MIMAT0003717	11066
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HM-1//U1SNRNPBP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SNRNP35	chr12:123948971(+) A-I      intronic chr12:123945142(+) A-I      intronic chr12:123948974(+) A-I      intronic chr12:123948928(+) A-I      intronic chr12:123948028(+) A-I      intronic chr12:123947948(+) A-I      intronic chr12:123943284(+) A-I      intronic chr12:123943282(+) A-I      intronic chr12:123945127(+) A-I      intronic chr12:123948923(+) A-I      intronic chr12:123945063(+) A-I      intronic chr12:123943961(+) A-I      intronic chr12:123946449(+) A-I      intronic chr12:123945884(+) A-I      intronic chr12:123945160(+) A-I      intronic chr12:123946398(+) A-I      intronic chr12:123945576(+) A-I      intronic chr12:123945284(+) A-I      intronic chr12:123945935(+) A-I      intronic chr12:123945275(+) A-I      intronic chr12:123945895(+) A-I      intronic chr12:123945165(+) A-I      intronic chr12:123945158(+) A-I      intronic chr12:123945880(+) A-I      intronic chr12:123948916(+) A-I      intronic chr12:123943609(+) A-I      intronic chr12:123947694(+) A-I      intronic chr12:123947792(+) A-I      intronic chr12:123945212(+) A-I      intronic chr12:123947661(+) A-I      intronic chr12:123946333(+) A-I      intronic chr12:123945131(+) A-I      intronic chr12:123947647(+) A-I      intronic chr12:123943960(+) A-I      intronic chr12:123945058(+) A-I      intronic chr12:123945684(+) A-I      intronic chr12:123945245(+) A-I      intronic chr12:123945162(+) A-I      intronic chr12:123947737(+) A-I      intronic chr12:123947773(+) A-I      intronic chr12:123945051(+) A-I      intronic chr12:123945719(+) A-I      intronic chr12:123948654(+) A-I      intronic chr12:123943982(+) A-I      intronic chr12:123945157(+) A-I      intronic chr12:123947744(+) A-I      intronic chr12:123946338(+) A-I      intronic chr12:123948506(+) A-I      intronic chr12:123945112(+) A-I      intronic chr12:123948580(+) A-I      intronic chr12:123943600(+) A-I      intronic chr12:123943720(+) A-I      intronic chr12:123945400(+) A-I      intronic chr12:123945090(+) A-I      intronic chr12:123947844(+) A-I      intronic chr12:123945084(+) A-I      intronic chr12:123948105(+) A-I      intronic chr12:123945414(+) A-I      intronic chr12:123947856(+) A-I      intronic chr12:123947658(+) A-I      intronic chr12:123945280(+) A-I      intronic chr12:123945171(+) A-I      intronic chr12:123945111(+) A-I      intronic chr12:123947871(+) A-I      intronic chr12:123945419(+) A-I      intronic chr12:123945057(+) A-I      intronic chr12:123948996(+) A-I      intronic chr12:123945220(+) A-I      intronic chr12:123948108(+) A-I      intronic chr12:123945388(+) A-I      intronic chr12:123946349(+) A-I      intronic chr12:123943973(+) A-I      intronic chr12:123943586(+) A-I      intronic chr12:123944647(+) A-I      intronic chr12:123947799(+) A-I      intronic chr12:123947312(+) A-I      intronic chr12:123948988(+) A-I      intronic chr12:123943979(+) A-I      intronic chr12:123945198(+) A-I      intronic chr12:123947701(+) A-I      intronic chr12:123948575(+) A-I      intronic chr12:123945308(+) A-I      intronic chr12:123945161(+) A-I      intronic chr12:123945335(+) A-I      intronic chr12:123945122(+) A-I      intronic chr12:123947818(+) A-I      intronic chr12:123945405(+) A-I      intronic chr12:123945345(+) A-I      intronic chr12:123947221(+) A-I      intronic chr12:123945049(+) A-I      intronic chr12:123945103(+) A-I      intronic chr12:123945199(+) A-I      intronic chr12:123946426(+) A-I      intronic chr12:123943672(+) A-I      intronic chr12:123943608(+) A-I      intronic chr12:123947789(+) A-I      intronic chr12:123943622(+) A-I      intronic chr12:123948127(+) A-I      intronic chr12:123947734(+) A-I      intronic chr12:123943682(+) A-I      intronic chr12:123943671(+) A-I      intronic chr12:123946348(+) A-I      intronic chr12:123948567(+) A-I      intronic chr12:123948043(+) A-I      intronic chr12:123943942(+) A-I      intronic chr12:123947874(+) A-I      intronic chr12:123945278(+) A-I      intronic chr12:123946421(+) A-I      intronic chr12:123948620(+) A-I      intronic chr12:123945283(+) A-I      intronic chr12:123947747(+) A-I      intronic chr12:123947165(+) A-I      intronic chr12:123948926(+) A-I      intronic chr12:123951235(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SNRNP35	chr12:123944149(+) A-I intron -    22327324 chr12:123945051(+) A-I intron -    22327324 chr12:123946338(+) A-I intron -    22327324 chr12:123947661(+) A-I intron -    21960545 chr12:123944214(+) A-G intron -    21725310   //22484847 chr12:123943534(+) A-G intron -    22484847 chr12:123943536(+) A-G intron -    22484847 chr12:123943582(+) A-G intron -    22484847 chr12:123943583(+) A-G intron -    22484847 chr12:123943586(+) A-G intron -    22484847 chr12:123943600(+) A-G intron -    22484847 chr12:123943671(+) A-G intron -    22484847 chr12:123943937(+) A-G intron -    22484847 chr12:123943942(+) A-G intron -    22484847 chr12:123944173(+) A-G intron -    22484847 chr12:123944174(+) A-G intron -    22484847 chr12:123944176(+) A-G intron -    22484847 chr12:123944188(+) A-G intron -    22484847 chr12:123944215(+) A-G intron -    22484847 chr12:123945049(+) A-G intron -    22484847 chr12:123945051(+) A-G intron -    22484847 chr12:123945057(+) A-G intron -    22484847 chr12:123945058(+) A-G intron -    22484847 chr12:123945199(+) A-G intron -    22484847 chr12:123945212(+) A-G intron -    22484847 chr12:123946338(+) A-G intron -    22484847 chr12:123947661(+) A-G intron -    22484847 chr12:123947701(+) A-G intron -    22484847 chr12:123948988(+) A-G intron -    22484847 chr12:123948996(+) A-G intron -    22484847 chr12:123943608(+) A-G intron -    22484847 chr12:123943672(+) A-G intron -    22484847 chr12:123943682(+) A-G intron -    22484847 chr12:123943938(+) A-G intron -    22484847 chr12:123943973(+) A-G intron -    22484847 chr12:123944079(+) A-G intron -    22484847 chr12:123944080(+) A-G intron -    22484847 chr12:123944148(+) A-G intron -    22484847 chr12:123944175(+) A-G intron -    22484847 chr12:123944220(+) A-G intron -    22484847 chr12:123944241(+) A-G intron -    22484847 chr12:123944255(+) A-G intron -    22484847 chr12:123944267(+) A-G intron -    22484847 chr12:123944276(+) A-G intron -    22484847 chr12:123945122(+) A-G intron -    22484847 chr12:123945220(+) A-G intron -    22484847 chr12:123945278(+) A-G intron -    22484847 chr12:123945280(+) A-G intron -    22484847 chr12:123945345(+) A-G intron -    22484847 chr12:123945719(+) A-G intron -    22484847 chr12:123946333(+) A-G intron -    22484847 chr12:123947818(+) A-G intron -    22484847 chr12:123948043(+) A-G intron -    22484847 chr12:123948557(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SNRNP35	chr12:123943512-123943513(+) m6A exon//intron       24284625//25456834//24981863 chr12:123943618-123943619(+) m6A exon//intron       24284625 chr12:123950160-123950161(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr12:123950257-123950258(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr12:123950262-123950263(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:123950270-123950271(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:123950280-123950281(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:123950340-123950341(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:123950460-123950461(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:123950477-123950478(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:123950562-123950563(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:123950578-123950579(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:123950662-123950663(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:123950670-123950671(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:123950678-123950679(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:123950691-123950692(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:123950775-123950776(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:123950810-123950811(+) m1A CDS//intron       26863196 chr12:123950843-123950844(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:123950922-123950923(+) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22608085 chr12:123950970-123950971(+) m6A 3'UTR//intron       24981863 chr12:123955940-123955941(+) m6A exon       - chr12:123955975-123955976(+) m6A exon       - chr12:123956739-123956740(+) m6A exon       24284625//27773535//22608085 chr12:123956871-123956872(+) m6A exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:123956897-123956898(+) m6A exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:123956948-123956949(+) m6A exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:123957161-123957162(+) m6A exon       24284625//24209618//25456834//24981863//27773535//22608085 chr12:123957227-123957228(+) m6A exon       24284625//24209618//27773535 chr12:123957247-123957248(+) m6A exon       24284625//24209618//27773535 chr12:123957305-123957306(+) m6A exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SNRNP35	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: SNRNP35

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.