Basic Information:

  VIRBase ID:  

VHID00375270

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9928

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          MAP3K2:  NM_006609     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	MAP3K2
miRBase Accession/Entrez ID	MIMAT0003717	10746
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	MEKK2//MEKK2B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MAP3K2	chr2:128113339(-) A-I      intronic chr2:128092221(-) A-I      intronic chr2:128113341(-) A-I      intronic chr2:128113340(-) A-I      intronic chr2:128113329(-) A-I      intronic chr2:128085794(-) A-I      intronic chr2:128113328(-) A-I      intronic chr2:128113327(-) A-I      intronic chr2:128092289(-) A-I      intronic chr2:128092224(-) A-I      intronic chr2:128092223(-) A-I      intronic chr2:128092181(-) A-I      intronic chr2:128092170(-) A-I      intronic chr2:128092166(-) A-I      intronic chr2:128070151(-) A-I      intronic chr2:128125954(-) A-I      intronic chr2:128090549(-) A-I      intronic chr2:128126076(-) A-I      intronic chr2:128126079(-) A-I      intronic chr2:128126086(-) A-I      intronic chr2:128126450(-) A-I      intronic chr2:128133022(-) A-I      intronic chr2:128133074(-) A-I      intronic chr2:128134468(-) A-I      intronic chr2:128134491(-) A-I      intronic chr2:128134509(-) A-I      intronic chr2:128135543(-) A-I      intronic chr2:128098633(-) A-I      intronic chr2:128092625(-) A-I      intronic chr2:128085837(-) A-I      intronic chr2:128125789(-) A-I      intronic chr2:128085729(-) A-I      intronic chr2:128098694(-) A-I      intronic chr2:128105881(-) A-I      intronic chr2:128085727(-) A-I      intronic chr2:128085702(-) A-I      intronic chr2:128085671(-) A-I      intronic chr2:128080910(-) A-I      intronic chr2:128080875(-) A-I      intronic chr2:128080308(-) A-I      intronic chr2:128098385(-) A-I      intronic chr2:128098384(-) A-I      intronic chr2:128098187(-) A-I      intronic chr2:128092616(-) A-I      intronic chr2:128133221(-) A-I      intronic chr2:128092316(-) A-I      intronic chr2:128092215(-) A-I      intronic chr2:128092198(-) A-I      intronic chr2:128098698(-) A-I      intronic chr2:128098730(-) A-I      intronic chr2:128101373(-) A-I      intronic chr2:128101447(-) A-I      intronic chr2:128102146(-) A-I      intronic chr2:128102524(-) A-I      intronic chr2:128105864(-) A-I      intronic chr2:128105878(-) A-I      intronic chr2:128105888(-) A-I      intronic chr2:128105901(-) A-I      intronic chr2:128114136(-) A-I      intronic chr2:128118807(-) A-I      intronic chr2:128121446(-) A-I      intronic chr2:128122487(-) A-I      intronic chr2:128122500(-) A-I      intronic chr2:128122501(-) A-I      intronic chr2:128125152(-) A-I      intronic chr2:128125241(-) A-I      intronic chr2:128125250(-) A-I      intronic chr2:128125672(-) A-I      intronic chr2:128125776(-) A-I      intronic chr2:128133155(-) A-I      intronic chr2:128089319(-) A-I      intronic chr2:128089284(-) A-I      intronic chr2:128087160(-) A-I      intronic chr2:128087159(-) A-I      intronic chr2:128087141(-) A-I      intronic chr2:128087112(-) A-I      intronic chr2:128125896(-) A-I      intronic chr2:128121397(-) A-I      intronic chr2:128133156(-) A-I      intronic chr2:128122596(-) A-I      intronic chr2:128121357(-) A-I      intronic chr2:128089352(-) A-I      intronic chr2:128090646(-) A-I      intronic chr2:128085696(-) A-I      intronic chr2:128092219(-) A-I      intronic chr2:128091492(-) A-I      intronic chr2:128121344(-) A-I      intronic chr2:128092586(-) A-I      intronic chr2:128134484(-) A-I      intronic chr2:128126661(-) A-I      intronic chr2:128126617(-) A-I      intronic chr2:128125247(-) A-I      intronic chr2:128126454(-) A-I      intronic chr2:128092572(-) A-I      intronic chr2:128080364(-) A-I      intronic chr2:128133082(-) A-I      intronic chr2:128090449(-) A-I      intronic chr2:128134513(-) A-I      intronic chr2:128091483(-) A-I      intronic chr2:128085694(-) A-I      intronic chr2:128080334(-) A-I      intronic chr2:128092297(-) A-I      intronic chr2:128102160(-) A-I      intronic chr2:128134568(-) A-I      intronic chr2:128092542(-) A-I      intronic chr2:128122582(-) A-I      intronic chr2:128091551(-) A-I      intronic chr2:128125641(-) A-I      intronic chr2:128121496(-) A-I      intronic chr2:128125309(-) A-I      intronic chr2:128087109(-) A-I      intronic chr2:128092099(-) A-I      intronic chr2:128091509(-) A-I      intronic chr2:128134525(-) A-I      intronic chr2:128125942(-) A-I      intronic chr2:128092523(-) A-I      intronic chr2:128125257(-) A-I      intronic chr2:128092565(-) A-I      intronic chr2:128091472(-) A-I      intronic chr2:128092515(-) A-I      intronic chr2:128092238(-) A-I      intronic chr2:128092581(-) A-I      intronic chr2:128092578(-) A-I      intronic chr2:128092635(-) A-I      intronic chr2:128092443(-) A-I      intronic chr2:128092401(-) A-I      intronic chr2:128136665(-) A-I      intronic chr2:128092540(-) A-I      intronic chr2:128092381(-) A-I      intronic chr2:128085849(-) A-I      intronic chr2:128107549(-) A-I      intronic chr2:128092637(-) A-I      intronic chr2:128125286(-) A-I      intronic chr2:128081089(-) A-I      intronic chr2:128102690(-) A-I      intronic chr2:128123859(-) A-I      intronic chr2:128101529(-) A-I      intronic chr2:128141288(-) A-I      intronic chr2:128116422(-) A-I      intronic chr2:128102163(-) A-I      intronic chr2:128092617(-) A-I      intronic chr2:128109712(-) A-I      intronic chr2:128092257(-) A-I      intronic chr2:128098048(-) A-I      intronic chr2:128109555(-) A-I      intronic chr2:128105816(-) A-I      intronic chr2:128125355(-) A-I      intronic chr2:128089375(-) A-I      intronic chr2:128125964(-) A-I      intronic chr2:128126115(-) A-I      intronic chr2:128085799(-) A-I      intronic chr2:128092458(-) A-I      intronic chr2:128134494(-) A-I      intronic chr2:128091614(-) A-I      intronic chr2:128124523(-) A-I      intronic chr2:128126952(-) A-I      intronic chr2:128090672(-) A-I      intronic chr2:128080291(-) A-I      intronic chr2:128126798(-) A-I      intronic chr2:128122453(-) A-I      intronic chr2:128102523(-) A-I      intronic chr2:128091613(-) A-I      intronic chr2:128126600(-) A-I      intronic chr2:128105950(-) A-I      intronic chr2:128123952(-) A-I      intronic chr2:128090597(-) A-I      intronic chr2:128116423(-) A-I      intronic chr2:128090571(-) A-I      intronic chr2:128092485(-) A-I      intronic chr2:128125841(-) A-I      intronic chr2:128133159(-) A-I      intronic chr2:128085829(-) A-I      intronic chr2:128126414(-) A-I      intronic chr2:128123877(-) A-I      intronic chr2:128126620(-) A-I      intronic chr2:128091662(-) A-I      intronic chr2:128126621(-) A-I      intronic chr2:128121479(-) A-I      intronic chr2:128092318(-) A-I      intronic chr2:128133097(-) A-I      intronic chr2:128089463(-) A-I      intronic chr2:128141276(-) A-I      intronic chr2:128085815(-) A-I      intronic chr2:128124620(-) A-I      intronic chr2:128085738(-) A-I      intronic chr2:128105957(-) A-I      intronic chr2:128085751(-) A-I      intronic chr2:128121400(-) A-I      intronic chr2:128105729(-) A-I      intronic chr2:128092160(-) A-I      intronic chr2:128106875(-) A-I      intronic chr2:128134618(-) A-I      intronic chr2:128085663(-) A-I      intronic chr2:128092239(-) A-I      intronic chr2:128122654(-) A-I      intronic chr2:128125312(-) A-I      intronic chr2:128132993(-) A-I      intronic chr2:128121451(-) A-I      intronic chr2:128136440(-) A-I      intronic chr2:128092263(-) A-I      intronic chr2:128141287(-) A-I      intronic chr2:128105692(-) A-I      intronic chr2:128134490(-) A-I      intronic chr2:128122592(-) A-I      intronic chr2:128105761(-) A-I      intronic chr2:128105737(-) A-I      intronic chr2:128125816(-) A-I      intronic chr2:128134631(-) A-I      intronic chr2:128126731(-) A-I      intronic chr2:128091453(-) A-I      intronic chr2:128090594(-) A-I      intronic chr2:128126964(-) A-I      intronic chr2:128091642(-) A-I      intronic chr2:128091458(-) A-I      intronic chr2:128092311(-) A-I      intronic chr2:128090447(-) A-I      intronic chr2:128085788(-) A-I      intronic chr2:128126460(-) A-I      intronic chr2:128092110(-) A-I      intronic chr2:128092202(-) A-I      intronic chr2:128121432(-) A-I      intronic chr2:128102537(-) A-I      intronic chr2:128125815(-) A-I      intronic chr2:128136501(-) A-I      intronic chr2:128092422(-) A-I      intronic chr2:128092252(-) A-I      intronic chr2:128091471(-) A-I      intronic chr2:128085845(-) A-I      intronic chr2:128141588(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MAP3K2	chr2:128091642(-) A-I intron -    22327324 chr2:128092160(-) A-I intron -    22327324 chr2:128092311(-) A-I intron -    22327324 chr2:128092485(-) A-I intron -    22028664   //22327324 chr2:128092381(-) A-I intron -    22028664 chr2:128092399(-) A-I intron -    22028664 chr2:128092401(-) A-I intron -    22028664 chr2:128092422(-) A-I intron -    22028664 chr2:128092443(-) A-I intron -    22028664 chr2:128092458(-) A-I intron -    22028664 chr2:128092515(-) A-I intron -    22028664 chr2:128092523(-) A-I intron -    22028664 chr2:128092540(-) A-I intron -    22028664 chr2:128092541(-) A-I intron -    22028664 chr2:128092542(-) A-I intron -    22028664 chr2:128092543(-) A-I intron -    22028664 chr2:128092565(-) A-I intron -    22028664 chr2:128092572(-) A-I intron -    22028664 chr2:128092578(-) A-I intron -    22028664 chr2:128092581(-) A-I intron -    22028664 chr2:128092586(-) A-I intron -    22028664 chr2:128092617(-) A-I intron -    22028664 chr2:128092635(-) A-I intron -    22028664 chr2:128092637(-) A-I intron -    22028664 chr2:128080291(-) A-G intron -    22484847 chr2:128080334(-) A-G intron -    22484847 chr2:128080364(-) A-G intron -    22484847 chr2:128085663(-) A-G intron -    22484847 chr2:128085694(-) A-G intron -    22484847 chr2:128085696(-) A-G intron -    22484847 chr2:128085738(-) A-G intron -    22484847 chr2:128085741(-) A-G intron -    22484847 chr2:128085751(-) A-G intron -    22484847 chr2:128085768(-) A-G intron -    22484847 chr2:128085788(-) A-G intron -    22484847 chr2:128085799(-) A-G intron -    22484847 chr2:128085815(-) A-G intron -    22484847 chr2:128085849(-) A-G intron -    22484847 chr2:128087043(-) A-G intron -    22484847 chr2:128087071(-) A-G intron -    22484847 chr2:128087097(-) A-G intron -    22484847 chr2:128087109(-) A-G intron -    22484847 chr2:128087137(-) A-G intron -    22484847 chr2:128087217(-) A-G intron -    22484847 chr2:128089376(-) A-G intron -    22484847 chr2:128090597(-) A-G intron -    22484847 chr2:128090672(-) A-G intron -    22484847 chr2:128091472(-) A-G intron -    22484847 chr2:128091492(-) A-G intron -    22484847 chr2:128091642(-) A-G intron -    22484847 chr2:128091662(-) A-G intron -    22484847 chr2:128092085(-) A-G intron -    22484847 chr2:128092099(-) A-G intron -    22484847 chr2:128092110(-) A-G intron -    22484847 chr2:128092160(-) A-G intron -    22484847 chr2:128092202(-) A-G intron -    22484847 chr2:128092311(-) A-G intron -    22484847 chr2:128092422(-) A-G intron -    22484847 chr2:128092458(-) A-G intron -    22484847 chr2:128092485(-) A-G intron -    22484847 chr2:128092541(-) A-G intron -    22484847 chr2:128092542(-) A-G intron -    22484847 chr2:128092543(-) A-G intron -    22484847 chr2:128098133(-) A-G intron -    22484847 chr2:128098181(-) A-G intron -    22484847 chr2:128098704(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MAP3K2	chr2:128058051-128058052(-) m6A 3'UTR       27773535 chr2:128058068-128058069(-) m6A 3'UTR       27773535 chr2:128058090-128058091(-) m6A 3'UTR       27773535 chr2:128060392-128060393(-) m6A 3'UTR       24981863 chr2:128060413-128060414(-) m6A 3'UTR       24981863 chr2:128060436-128060437(-) m6A 3'UTR       24981863 chr2:128060878-128060879(-) m6A 3'UTR       27773535 chr2:128060981-128060982(-) m6A 3'UTR       27773535 chr2:128060999-128061000(-) m6A 3'UTR       27773535 chr2:128061047-128061048(-) m6A 3'UTR       27773535 chr2:128062314-128062315(-) m6A 3'UTR       24981863 chr2:128062352-128062353(-) m6A 3'UTR       24981863 chr2:128062392-128062393(-) m6A 3'UTR       24981863//27773535 chr2:128062401-128062402(-) m6A 3'UTR       24981863//27773535 chr2:128062429-128062430(-) m6A 3'UTR       24981863//27773535 chr2:128063398-128063399(-) m6A 3'UTR       24981863 chr2:128063403-128063404(-) m6A 3'UTR       24981863 chr2:128063418-128063419(-) m6A 3'UTR       24981863//28052920 chr2:128063495-128063496(-) m6A 3'UTR       24981863 chr2:128063796-128063797(-) m6A 3'UTR       24981863 chr2:128063803-128063804(-) m6A 3'UTR       24981863 chr2:128063834-128063835(-) m6A 3'UTR       24981863 chr2:128064366-128064367(-) m6A 3'UTR       27773535 chr2:128064374-128064375(-) m6A 3'UTR       27773535 chr2:128064417-128064418(-) m6A 3'UTR       27773535 chr2:128064450-128064451(-) m6A 3'UTR       27773535 chr2:128064478-128064479(-) m6A 3'UTR       27773535 chr2:128065044-128065045(-) m6A 3'UTR       24981863//27773535//22608085 chr2:128065187-128065188(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr2:128065202-128065203(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr2:128065208-128065209(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr2:128065251-128065252(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr2:128065278-128065279(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr2:128066166-128066167(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr2:128066248-128066249(-) m6A CDS       24209618//24981863//27773535//27371828//22608085 chr2:128066266-128066267(-) m6A CDS       24209618//24981863//27773535//27371828//22608085 chr2:128066300-128066301(-) m6A CDS       24209618//27371828 chr2:128079641-128079642(-) m6A CDS       27773535 chr2:128079665-128079666(-) m6A CDS       27773535 chr2:128079789-128079790(-) m6A CDS       27773535 chr2:128079798-128079799(-) m6A CDS       27773535 chr2:128079819-128079820(-) m6A CDS       - chr2:128093478-128093479(-) m6A CDS       24981863 chr2:128093517-128093518(-) m6A CDS       24981863 chr2:128093526-128093527(-) m6A CDS       24981863 chr2:128095330-128095331(-) m6A CDS       24981863 chr2:128096510-128096511(-) m6A CDS       24981863 chr2:128096542-128096543(-) m6A CDS       24981863 chr2:128145272-128145273(-) m6A 5'UTR//intron       27773536 chr2:128145430-128145431(-) m6A 5'UTR//intron       24284625//27773536 chr2:128145831-128145832(-) m6A 5'UTR       27773536 chr2:128145888-128145889(-) m6A 5'UTR       27773536 chr2:128146008-128146009(-) m6A 5'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MAP3K2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: MAP3K2

Evidence Support:

Strong-Evidence	Ago2-IP//Luciferase reporter assay//RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.