Detail Information

Basic Information:


  VIRBase ID:  

VHID00375169

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9070

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:           G3BP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART18-5p G3BP2
miRBase
Accession/Entrez ID		 MIMAT0003717 9908
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR G3BP2
chr4:76588608(-) A-I      intronic
chr4:76592962(-) A-I      intronic
chr4:76592974(-) A-I      intronic
chr4:76575031(-) A-I      intronic
chr4:76588517(-) A-I      intronic
chr4:76588590(-) A-I      intronic
chr4:76588592(-) A-I      intronic
chr4:76588839(-) A-I      intronic
chr4:76588925(-) A-I      intronic
chr4:76589216(-) A-I      intronic
chr4:76589218(-) A-I      intronic
chr4:76589232(-) A-I      intronic
chr4:76589241(-) A-I      intronic
chr4:76589263(-) A-I      intronic
chr4:76589339(-) A-I      intronic
chr4:76575542(-) A-I      intronic
chr4:76573339(-) A-I      intronic
chr4:76586759(-) A-I      intronic
chr4:76590027(-) A-I      intronic
chr4:76592942(-) A-I      intronic
chr4:76589137(-) A-I      intronic
chr4:76588981(-) A-I      intronic
chr4:76588659(-) A-I      intronic
chr4:76590019(-) A-I      intronic
chr4:76590149(-) A-I      intronic
chr4:76588944(-) A-I      intronic
chr4:76590191(-) A-I      intronic
chr4:76589250(-) A-I      intronic
chr4:76590025(-) A-I      intronic
chr4:76590686(-) A-I      intronic
chr4:76588604(-) A-I      intronic
chr4:76575535(-) A-I      intronic
chr4:76590794(-) A-I      intronic
chr4:76589970(-) A-I      intronic
chr4:76575555(-) A-I      intronic
chr4:76589155(-) A-I      intronic
chr4:76587619(-) A-I      intronic
chr4:76588802(-) A-I      intronic
chr4:76592988(-) A-I      intronic
chr4:76587518(-) A-I      intronic
chr4:76581339(-) A-I      intronic
chr4:76588705(-) A-I      intronic
chr4:76586525(-) A-I      intronic
chr4:76595110(-) A-I      intronic
chr4:76590700(-) A-I      intronic
chr4:76589262(-) A-I      intronic
chr4:76575916(-) A-I      intronic
chr4:76589206(-) A-I      intronic
chr4:76589920(-) A-I      intronic
chr4:76588483(-) A-I      intronic
chr4:76589590(-) A-I      intronic
chr4:76576025(-) A-I      intronic
chr4:76589295(-) A-I      intronic
chr4:76575979(-) A-I      intronic
chr4:76575965(-) A-I      intronic
chr4:76588922(-) A-I      intronic
chr4:76575917(-) A-I      intronic
chr4:76589200(-) A-I      intronic
chr4:76588501(-) A-I      intronic
chr4:76589196(-) A-I      intronic
chr4:76581403(-) A-I      intronic
chr4:76588980(-) A-I      intronic
chr4:76589556(-) A-I      intronic
chr4:76587609(-) A-I      intronic
chr4:76586550(-) A-I      intronic
chr4:76589247(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED G3BP2
chr4:76573549(-) G-T intron -    22484847
chr4:76575535(-) A-G intron -    22484847
chr4:76575613(-) T-G intron -    22484847
chr4:76575916(-) A-G intron -    22484847
chr4:76575917(-) A-G intron -    22484847
chr4:76575965(-) A-G intron -    22484847
chr4:76588483(-) A-G intron -    22484847
chr4:76588604(-) A-G intron -    22484847
chr4:76588655(-) A-G intron -    22484847
chr4:76588659(-) A-G intron -    22484847
chr4:76588705(-) A-G intron -    22484847
chr4:76588802(-) A-G intron -    22484847
chr4:76588922(-) A-G intron -    22484847
chr4:76588956(-) A-G intron -    22484847
chr4:76588957(-) A-G intron -    22484847
chr4:76588980(-) A-G intron -    22484847
chr4:76588981(-) A-G intron -    22484847
chr4:76589137(-) A-G intron -    22484847
chr4:76589196(-) A-G intron -    22484847
chr4:76589200(-) A-G intron -    22484847
chr4:76589206(-) A-G intron -    22484847
chr4:76589247(-) A-G intron -    22484847
chr4:76589250(-) A-G intron -    22484847
chr4:76589261(-) A-G intron -    22484847
chr4:76589295(-) A-G intron -    22484847
chr4:76589312(-) A-G intron -    22484847
chr4:76589338(-) A-G intron -    22484847
chr4:76589590(-) A-C intron -    22484847
chr4:76589920(-) A-G intron -    22484847
chr4:76590019(-) A-G intron -    22484847
chr4:76590719(-) A-G intron -    22484847
chr4:76593034(-) A-G intron -    22484847
chr4:76595034(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase G3BP2
chr4:76569891-76569892(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr4:76569920-76569921(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr4:76569940-76569941(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr4:76569980-76569981(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr4:76569991-76569992(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr4:76570122-76570123(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr4:76570164-76570165(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr4:76570174-76570175(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr4:76570242-76570243(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr4:76570337-76570338(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr4:76570347-76570348(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr4:76570366-76570367(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr4:76570389-76570390(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr4:76570405-76570406(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr4:76570459-76570460(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr4:76570625-76570626(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr4:76570654-76570655(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr4:76570673-76570674(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr4:76570703-76570704(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr4:76570813-76570814(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr4:76570837-76570838(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr4:76571548-76571549(-) m6A CDS       24981863//26404942//27773535
chr4:76571620-76571621(-) m6A CDS       27773535
chr4:76574023-76574024(-) m6A exon//intron       27371828
chr4:76574030-76574031(-) m6A exon//intron       27371828
chr4:76580258-76580259(-) m6A 3'UTR//CDS//exon       24981863
chr4:76580279-76580280(-) m6A 3'UTR//CDS//exon       24981863
chr4:76580315-76580316(-) m6A 3'UTR//CDS//exon       24981863
chr4:76580325-76580326(-) m6A 3'UTR//CDS//exon       24981863
chr4:76580345-76580346(-) m6A 3'UTR//CDS//exon       24981863
chr4:76580359-76580360(-) m6A 3'UTR//CDS//exon       24981863
chr4:76580362-76580363(-) Am 3'UTR//CDS//exon       -
chr4:76580365-76580366(-) m6A 3'UTR//CDS//exon       24981863
chr4:76580384-76580385(-) m6A 3'UTR//CDS//exon       24981863
chr4:76580390-76580391(-) m6A 3'UTR//CDS//exon       24981863
chr4:76581001-76581002(-) m6A 3'UTR//CDS//exon       24981863
chr4:76581016-76581017(-) m6A 3'UTR//CDS//exon       24981863
chr4:76581028-76581029(-) m6A 3'UTR//CDS//exon       24981863
chr4:76598462-76598463(-) m6A 5'UTR//exon//intron       24284625//24981863//27773536
chr4:76598527-76598528(-) m6A 5'UTR//exon//intron       24284625//24981863
chr4:76598628-76598629(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate G3BP2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART18-5p
Interactor2: G3BP2

Evidence Support:


Strong-Evidence RT-PCR//Western blot
Prediction-Evidence miRanda//Targetscan
Support Database VIRmiRNA//VmiReg

References:


PMID 25012295 Target region 3'UTR
Source VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BL2 cells//BJAB cells Interactor2 expression None
Description BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.

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