Basic Information:

  VIRBase ID:  

VHID00375126

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          RUBCN:  NM_014687     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	RUBCN
miRBase Accession/Entrez ID	MIMAT0003717	9711
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA0226//RUBICON//SCAR15

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RUBCN	chr3:197459385(-) A-I      intronic chr3:197459356(-) A-I      intronic chr3:197459354(-) A-I      intronic chr3:197459349(-) A-I      intronic chr3:197459345(-) A-I      intronic chr3:197459333(-) A-I      intronic chr3:197459323(-) A-I      intronic chr3:197459313(-) A-I      intronic chr3:197459296(-) A-I      intronic chr3:197459282(-) A-I      intronic chr3:197456723(-) A-I      intronic chr3:197456397(-) A-I      intronic chr3:197456388(-) A-I      intronic chr3:197461269(-) A-I      intronic chr3:197462083(-) A-I      intronic chr3:197462515(-) A-I      intronic chr3:197462676(-) A-I      intronic chr3:197462695(-) A-I      intronic chr3:197462734(-) A-I      intronic chr3:197474373(-) A-I      intronic chr3:197455986(-) A-I      intronic chr3:197455890(-) A-I      intronic chr3:197455060(-) A-I      intronic chr3:197455037(-) A-I      intronic chr3:197454106(-) A-I      intronic chr3:197454042(-) A-I      intronic chr3:197474364(-) A-I      intronic chr3:197466727(-) A-I      intronic chr3:197454037(-) A-I      intronic chr3:197453595(-) A-I      intronic chr3:197444143(-) A-I      intronic chr3:197444076(-) A-I      intronic chr3:197444061(-) A-I      intronic chr3:197453471(-) A-I      intronic chr3:197453390(-) A-I      intronic chr3:197453389(-) A-I      intronic chr3:197474359(-) A-I      intronic chr3:197472791(-) A-I      intronic chr3:197415019(-) A-I      intronic chr3:197443880(-) A-I      intronic chr3:197443870(-) A-I      intronic chr3:197415035(-) A-I      intronic chr3:197415125(-) A-I      intronic chr3:197417209(-) A-I      intronic chr3:197443864(-) A-I      intronic chr3:197417223(-) A-I      intronic chr3:197432768(-) A-I      intronic chr3:197432769(-) A-I      intronic chr3:197432787(-) A-I      intronic chr3:197453278(-) A-I      intronic chr3:197453256(-) A-I      intronic chr3:197453210(-) A-I      intronic chr3:197432795(-) A-I      intronic chr3:197432888(-) A-I      intronic chr3:197433970(-) A-I      intronic chr3:197434599(-) A-I      intronic chr3:197451884(-) A-I      intronic chr3:197434617(-) A-I      intronic chr3:197434653(-) A-I      intronic chr3:197450857(-) A-I      intronic chr3:197434707(-) A-I      intronic chr3:197434753(-) A-I      intronic chr3:197434778(-) A-I      intronic chr3:197434808(-) A-I      intronic chr3:197434816(-) A-I      intronic chr3:197434824(-) A-I      intronic chr3:197434829(-) A-I      intronic chr3:197435185(-) A-I      intronic chr3:197436376(-) A-I      intronic chr3:197436433(-) A-I      intronic chr3:197436452(-) A-I      intronic chr3:197436483(-) A-I      intronic chr3:197436518(-) A-I      intronic chr3:197436523(-) A-I      intronic chr3:197436796(-) A-I      intronic chr3:197436798(-) A-I      intronic chr3:197436857(-) A-I      intronic chr3:197443843(-) A-I      intronic chr3:197443800(-) A-I      intronic chr3:197460253(-) A-I      intronic chr3:197460231(-) A-I      intronic chr3:197460229(-) A-I      intronic chr3:197460172(-) A-I      intronic chr3:197443218(-) A-I      intronic chr3:197460126(-) A-I      intronic chr3:197460096(-) A-I      intronic chr3:197436861(-) A-I      intronic chr3:197443217(-) A-I      intronic chr3:197443202(-) A-I      intronic chr3:197443181(-) A-I      intronic chr3:197436869(-) A-I      intronic chr3:197436875(-) A-I      intronic chr3:197436917(-) A-I      intronic chr3:197437035(-) A-I      intronic chr3:197437371(-) A-I      intronic chr3:197437388(-) A-I      intronic chr3:197437389(-) A-I      intronic chr3:197437456(-) A-I      intronic chr3:197437789(-) A-I      intronic chr3:197437799(-) A-I      intronic chr3:197437802(-) A-I      intronic chr3:197437835(-) A-I      intronic chr3:197450820(-) A-I      intronic chr3:197450783(-) A-I      intronic chr3:197450721(-) A-I      intronic chr3:197443178(-) A-I      intronic chr3:197443163(-) A-I      intronic chr3:197437879(-) A-I      intronic chr3:197450348(-) A-I      intronic chr3:197447559(-) A-I      intronic chr3:197437924(-) A-I      intronic chr3:197437967(-) A-I      intronic chr3:197439868(-) A-I      intronic chr3:197440683(-) A-I      intronic chr3:197440701(-) A-I      intronic chr3:197447471(-) A-I      intronic chr3:197447443(-) A-I      intronic chr3:197447407(-) A-I      intronic chr3:197446346(-) A-I      intronic chr3:197446267(-) A-I      intronic chr3:197446225(-) A-I      intronic chr3:197446131(-) A-I      intronic chr3:197440702(-) A-I      intronic chr3:197440703(-) A-I      intronic chr3:197440711(-) A-I      intronic chr3:197460087(-) A-I      intronic chr3:197443131(-) A-I      intronic chr3:197443127(-) A-I      intronic chr3:197443114(-) A-I      intronic chr3:197443096(-) A-I      intronic chr3:197442078(-) A-I      intronic chr3:197442038(-) A-I      intronic chr3:197442016(-) A-I      intronic chr3:197441412(-) A-I      intronic chr3:197441395(-) A-I      intronic chr3:197446122(-) A-I      intronic chr3:197444307(-) A-I      intronic chr3:197444193(-) A-I      intronic chr3:197441393(-) A-I      intronic chr3:197441381(-) A-I      intronic chr3:197441356(-) A-I      intronic chr3:197468519(-) A-I      intronic chr3:197444150(-) A-I      intronic chr3:197468611(-) A-I      intronic chr3:197472663(-) A-I      intronic chr3:197472673(-) A-I      intronic chr3:197472745(-) A-I      intronic chr3:197440900(-) A-I      intronic chr3:197440895(-) A-I      intronic chr3:197440890(-) A-I      intronic chr3:197440823(-) A-I      intronic chr3:197440752(-) A-I      intronic chr3:197440716(-) A-I      intronic chr3:197415062(-) A-I      intronic chr3:197415065(-) A-I      intronic chr3:197415067(-) A-I      intronic chr3:197415073(-) A-I      intronic chr3:197415075(-) A-I      intronic chr3:197415077(-) A-I      intronic chr3:197415091(-) A-I      intronic chr3:197415101(-) A-I      intronic chr3:197415959(-) A-I      intronic chr3:197416012(-) A-I      intronic chr3:197416028(-) A-I      intronic chr3:197440909(-) A-I      intronic chr3:197459435(-) A-I      intronic chr3:197461126(-) A-I      intronic chr3:197461042(-) A-I      intronic chr3:197461006(-) A-I      intronic chr3:197461004(-) A-I      intronic chr3:197459387(-) A-I      intronic chr3:197460984(-) A-I      intronic chr3:197460980(-) A-I      intronic chr3:197460979(-) A-I      intronic chr3:197460970(-) A-I      intronic chr3:197460908(-) A-I      intronic chr3:197460860(-) A-I      intronic chr3:197460317(-) A-I      intronic chr3:197462102(-) A-I      intronic chr3:197399757(-) A-I      3'UTR chr3:197399649(-) A-I      3'UTR chr3:197453549(-) A-I      intronic chr3:197443247(-) A-I      intronic chr3:197462175(-) A-I      intronic chr3:197433390(-) A-I      intronic chr3:197456209(-) A-I      intronic chr3:197450221(-) A-I      intronic chr3:197455983(-) A-I      intronic chr3:197450749(-) A-I      intronic chr3:197472664(-) A-I      intronic chr3:197440772(-) A-I      intronic chr3:197445423(-) A-I      intronic chr3:197462492(-) A-I      intronic chr3:197442100(-) A-I      intronic chr3:197416034(-) A-I      intronic chr3:197417246(-) A-I      intronic chr3:197468897(-) A-I      intronic chr3:197474972(-) A-I      intronic chr3:197465709(-) A-I      intronic chr3:197469242(-) A-I      intronic chr3:197443735(-) A-I      intronic chr3:197443844(-) A-I      intronic chr3:197449106(-) A-I      intronic chr3:197441473(-) A-I      intronic chr3:197454943(-) A-I      intronic chr3:197460141(-) A-I      intronic chr3:197447461(-) A-I      intronic chr3:197467771(-) A-I      intronic chr3:197416173(-) A-I      intronic chr3:197460237(-) A-I      intronic chr3:197462666(-) A-I      intronic chr3:197450256(-) A-I      intronic chr3:197452480(-) A-I      intronic chr3:197432763(-) A-I      intronic chr3:197441474(-) A-I      intronic chr3:197437968(-) A-I      intronic chr3:197465949(-) A-I      intronic chr3:197443876(-) A-I      intronic chr3:197436989(-) A-I      intronic chr3:197416033(-) A-I      intronic chr3:197465686(-) A-I      intronic chr3:197414995(-) A-I      intronic chr3:197456526(-) A-I      intronic chr3:197462187(-) A-I      intronic chr3:197443285(-) A-I      intronic chr3:197441465(-) A-I      intronic chr3:197468514(-) A-I      intronic chr3:197453948(-) A-I      intronic chr3:197451794(-) A-I      intronic chr3:197440756(-) A-I      intronic chr3:197450336(-) A-I      intronic chr3:197433415(-) A-I      intronic chr3:197435104(-) A-I      intronic chr3:197416098(-) A-I      intronic chr3:197450182(-) A-I      intronic chr3:197456553(-) A-I      intronic chr3:197462275(-) A-I      intronic chr3:197450812(-) A-I      intronic chr3:197459457(-) A-I      intronic chr3:197434783(-) A-I      intronic chr3:197447430(-) A-I      intronic chr3:197456467(-) A-I      intronic chr3:197452459(-) A-I      intronic chr3:197417143(-) A-I      intronic chr3:197399702(-) A-I      3'UTR chr3:197416079(-) A-I      intronic chr3:197455075(-) A-I      intronic chr3:197462725(-) A-I      intronic chr3:197462517(-) A-I      intronic chr3:197455973(-) A-I      intronic chr3:197440825(-) A-I      intronic chr3:197456657(-) A-I      intronic chr3:197454083(-) A-I      intronic chr3:197416125(-) A-I      intronic chr3:197445399(-) A-I      intronic chr3:197454084(-) A-I      intronic chr3:197446113(-) A-I      intronic chr3:197443269(-) A-I      intronic chr3:197432802(-) A-I      intronic chr3:197472807(-) A-I      intronic chr3:197436797(-) A-I      intronic chr3:197417126(-) A-I      intronic chr3:197415930(-) A-I      intronic chr3:197441330(-) A-I      intronic chr3:197450801(-) A-I      intronic chr3:197433958(-) A-I      intronic chr3:197472442(-) A-I      intronic chr3:197443909(-) A-I      intronic chr3:197462096(-) A-I      intronic chr3:197450804(-) A-I      intronic chr3:197443203(-) A-I      intronic chr3:197461068(-) A-I      intronic chr3:197443757(-) A-I      intronic chr3:197462158(-) A-I      intronic chr3:197435103(-) A-I      intronic chr3:197435144(-) A-I      intronic chr3:197450814(-) A-I      intronic chr3:197437990(-) A-I      intronic chr3:197461044(-) A-I      intronic chr3:197441361(-) A-I      intronic chr3:197436871(-) A-I      intronic chr3:197450227(-) A-I      intronic chr3:197443822(-) A-I      intronic chr3:197436390(-) A-I      intronic chr3:197460161(-) A-I      intronic chr3:197437027(-) A-I      intronic chr3:197455092(-) A-I      intronic chr3:197474272(-) A-I      intronic chr3:197432767(-) A-I      intronic chr3:197417270(-) A-I      intronic chr3:197440002(-) A-I      intronic chr3:197455878(-) A-I      intronic chr3:197451816(-) A-I      intronic chr3:197416172(-) A-I      intronic chr3:197461019(-) A-I      intronic chr3:197439933(-) A-I      intronic chr3:197460870(-) A-I      intronic chr3:197466689(-) A-I      intronic chr3:197443136(-) A-I      intronic chr3:197462742(-) A-I      intronic chr3:197441290(-) A-I      intronic chr3:197433433(-) A-I      intronic chr3:197433549(-) A-I      intronic chr3:197445498(-) A-I      intronic chr3:197436919(-) A-I      intronic chr3:197436892(-) A-I      intronic chr3:197452434(-) A-I      intronic chr3:197414932(-) A-I      intronic chr3:197456567(-) A-I      intronic chr3:197455976(-) A-I      intronic chr3:197461258(-) A-I      intronic chr3:197474319(-) A-I      intronic chr3:197460351(-) A-I      intronic chr3:197453535(-) A-I      intronic chr3:197435145(-) A-I      intronic chr3:197449014(-) A-I      intronic chr3:197466586(-) A-I      intronic chr3:197462222(-) A-I      intronic chr3:197462631(-) A-I      intronic chr3:197443826(-) A-I      intronic chr3:197460081(-) A-I      intronic chr3:197461071(-) A-I      intronic chr3:197451859(-) A-I      intronic chr3:197462018(-) A-I      intronic chr3:197415994(-) A-I      intronic chr3:197456612(-) A-I      intronic chr3:197417137(-) A-I      intronic chr3:197442077(-) A-I      intronic chr3:197443906(-) A-I      intronic chr3:197432841(-) A-I      intronic chr3:197456396(-) A-I      intronic chr3:197441299(-) A-I      intronic chr3:197436429(-) A-I      intronic chr3:197461090(-) A-I      intronic chr3:197436941(-) A-I      intronic chr3:197462076(-) A-I      intronic chr3:197442098(-) A-I      intronic chr3:197453684(-) A-I      intronic chr3:197455954(-) A-I      intronic chr3:197415975(-) A-I      intronic chr3:197445521(-) A-I      intronic chr3:197417222(-) A-I      intronic chr3:197436958(-) A-I      intronic chr3:197459434(-) A-I      intronic chr3:197435195(-) A-I      intronic chr3:197437861(-) A-I      intronic chr3:197449095(-) A-I      intronic chr3:197462122(-) A-I      intronic chr3:197453550(-) A-I      intronic chr3:197444125(-) A-I      intronic chr3:197462232(-) A-I      intronic chr3:197440689(-) A-I      intronic chr3:197436954(-) A-I      intronic chr3:197435183(-) A-I      intronic chr3:197462162(-) A-I      intronic chr3:197460084(-) A-I      intronic chr3:197437808(-) A-I      intronic chr3:197456566(-) A-I      intronic chr3:197456589(-) A-I      intronic chr3:197453539(-) A-I      intronic chr3:197438538(-) A-I      intronic chr3:197459456(-) A-I      intronic chr3:197475001(-) A-I      intronic chr3:197437851(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RUBCN	chr3:197398432-197398433(-) m6A 3'UTR       27773535 chr3:197398459-197398460(-) m6A 3'UTR       27773535 chr3:197401168-197401169(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:197401173-197401174(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:197401293-197401294(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:197401304-197401305(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:197401323-197401324(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:197401375-197401376(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:197401408-197401409(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:197401419-197401420(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:197401587-197401588(-) m6A 3'UTR       24284625//24209618//24981863//27773535 chr3:197401595-197401596(-) m6A 3'UTR       24284625//24209618//24981863//27773535 chr3:197401648-197401649(-) m6A 3'UTR       24209618//24981863//27773535 chr3:197401669-197401670(-) m6A 3'UTR       24209618//24981863//27773535 chr3:197401818-197401819(-) m6A 3'UTR       25456834//24981863//27371828 chr3:197401838-197401839(-) m6A 3'UTR       24209618//25456834//24981863//27371828 chr3:197401949-197401950(-) m6A CDS       24209618//24981863//27371828 chr3:197421349-197421350(-) m6A CDS       24981863 chr3:197427632-197427633(-) m6A CDS       27371828 chr3:197427738-197427739(-) m6A CDS       24284625//25456834//24981863//27371828//22608085 chr3:197427752-197427753(-) m6A CDS       24284625//25456834//24981863//27371828//22608085 chr3:197427930-197427931(-) m6A CDS       24284625//24981863//27773535 chr3:197427973-197427974(-) m6A CDS       24981863//27773535 chr3:197428649-197428650(-) m6A CDS//exon       27773535 chr3:197430455-197430456(-) m6A CDS//exon       27773535 chr3:197430460-197430461(-) m6A CDS//exon       27773535 chr3:197475105-197475106(-) m6A exon//intron       24981863 chr3:197475114-197475115(-) m6A exon//intron       24981863 chr3:197475124-197475125(-) m6A exon//intron       24284625//24981863 chr3:197475222-197475223(-) m6A exon//intron       24284625 chr3:197475230-197475231(-) m6A exon//intron       24284625 chr3:197475238-197475239(-) m6A exon//intron       24981863 chr3:197475263-197475264(-) m6A exon//intron       24981863 chr3:197475291-197475292(-) m6A exon//intron       24981863 chr3:197476160-197476161(-) m6A 5'UTR//exon       - chr3:197476192-197476193(-) m6A 5'UTR//exon       - chr3:197476390-197476391(-) m6A 5'UTR//exon       - chr3:197476458-197476459(-) m6A 5'UTR//exon       - chr3:197476531-197476532(-) m6A 5'UTR//exon       - chr3:197476546-197476547(-) m6A 5'UTR//exon       - chr3:197476580-197476581(-) m6A exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RUBCN	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: RUBCN

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.