Detail Information

Basic Information:


  VIRBase ID:  

VHID00374939

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9523

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:           CCDC6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART18-5p CCDC6
miRBase
Accession/Entrez ID		 MIMAT0003717 8030
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - D10S170//H4//PTC//TPC//TST1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCDC6
chr10:61555080(-) A-I      intronic
chr10:61591901(-) A-I      intronic
chr10:61555079(-) A-I      intronic
chr10:61555069(-) A-I      intronic
chr10:61555085(-) A-I      intronic
chr10:61555068(-) A-I      intronic
chr10:61580470(-) A-I      intronic
chr10:61577141(-) A-I      intronic
chr10:61653153(-) A-I      intronic
chr10:61657259(-) A-I      intronic
chr10:61577017(-) A-I      intronic
chr10:61593098(-) A-I      intronic
chr10:61601932(-) A-I      intronic
chr10:61653146(-) A-I      intronic
chr10:61580325(-) A-I      intronic
chr10:61577067(-) A-I      intronic
chr10:61577023(-) A-I      intronic
chr10:61653165(-) A-I      intronic
chr10:61577077(-) A-I      intronic
chr10:61653246(-) A-I      intronic
chr10:61653356(-) A-I      intronic
chr10:61653140(-) A-I      intronic
chr10:61613040(-) A-I      intronic
chr10:61653092(-) A-I      intronic
chr10:61580454(-) A-I      intronic
chr10:61653082(-) A-I      intronic
chr10:61657302(-) A-I      intronic
chr10:61593085(-) A-I      intronic
chr10:61593095(-) A-I      intronic
chr10:61653276(-) A-I      intronic
chr10:61657250(-) A-I      intronic
chr10:61653122(-) A-I      intronic
chr10:61657150(-) A-I      intronic
chr10:61577111(-) A-I      intronic
chr10:61608252(-) A-I      intronic
chr10:61660740(-) A-I      intronic
chr10:61608674(-) A-I      intronic
chr10:61577108(-) A-I      intronic
chr10:61608324(-) A-I      intronic
chr10:61653241(-) A-I      intronic
chr10:61657309(-) A-I      intronic
chr10:61577133(-) A-I      intronic
chr10:61582406(-) A-I      intronic
chr10:61653239(-) A-I      intronic
chr10:61608668(-) A-I      intronic
chr10:61602077(-) A-I      intronic
chr10:61580394(-) A-I      intronic
chr10:61662290(-) A-I      intronic
chr10:61577210(-) A-I      intronic
chr10:61608257(-) A-I      intronic
chr10:61653127(-) A-I      intronic
chr10:61608691(-) A-I      intronic
chr10:61608340(-) A-I      intronic
chr10:61577161(-) A-I      intronic
chr10:61608711(-) A-I      intronic
chr10:61608755(-) A-I      intronic
chr10:61569477(-) A-I      intronic
chr10:61556315(-) A-I      intronic
chr10:61556844(-) A-I      intronic
chr10:61556333(-) A-I      intronic
chr10:61556259(-) A-I      intronic
chr10:61653139(-) A-I      intronic
chr10:61569638(-) A-I      intronic
chr10:61569443(-) A-I      intronic
chr10:61569603(-) A-I      intronic
chr10:61569604(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CCDC6
chr10:61556844(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCDC6
chr10:61548549-61548550(-) m6A 3'UTR       27773535
chr10:61548616-61548617(-) m6A 3'UTR       27773535
chr10:61548800-61548801(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr10:61548824-61548825(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr10:61548836-61548837(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr10:61548917-61548918(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:61548934-61548935(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:61549920-61549921(-) m6A 3'UTR       27773535
chr10:61549991-61549992(-) m6A 3'UTR       27773535
chr10:61549997-61549998(-) m6A 3'UTR       27773535
chr10:61552422-61552423(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960
chr10:61552642-61552643(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:61552793-61552794(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr10:61554247-61554248(-) m6A CDS//exon       24284625//24209618//24981863//27773535
chr10:61564244-61564245(-) m6A CDS//exon       27773535
chr10:61564337-61564338(-) m6A exon//intron       27773535
chr10:61566781-61566782(-) m6A CDS//exon       24981863//27773535//27371828
chr10:61592285-61592286(-) m6A CDS       24981863//27773535
chr10:61592324-61592325(-) m6A CDS       24981863//27773535//27371828
chr10:61592345-61592346(-) m6A CDS       24981863//27773535//27371828
chr10:61592356-61592357(-) Cm CDS       -
chr10:61592372-61592373(-) m6A CDS       24981863//27773535//27371828
chr10:61592384-61592385(-) m6A CDS       24981863//27773535
chr10:61592390-61592391(-) m6A CDS       24981863//27773535
chr10:61612378-61612379(-) m6A CDS       24981863//27773535
chr10:61665910-61665911(-) m6A CDS       24209618//24981863
chr10:61665939-61665940(-) m6A CDS       24209618//24981863
chr10:61665947-61665948(-) m6A CDS       24209618//24981863
chr10:61665973-61665974(-) m6A CDS       24209618//24981863//27773536
chr10:61666174-61666175(-) m6A CDS       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CCDC6
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART18-5p
Interactor2: CCDC6

Evidence Support:


Strong-Evidence RT-PCR//Western blot
Weak-Evidence Microarray
Prediction-Evidence cRep//miRanda//Targetscan
Support Database RepTar//VIRmiRNA//VmiReg

References:


PMID 25012295 Target region 3'UTR
Source RepTar//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BL2 cells//BJAB cells Interactor2 expression None
Description BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.

Starting a new search, please wait ...