Basic Information:

  VIRBase ID:  

VHID00374869

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          TPR:  NM_003292     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	TPR
miRBase Accession/Entrez ID	MIMAT0003717	7175
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TPR	chr1:186281707-186281708(-) m6A 3'UTR       27773535 chr1:186281713-186281714(-) m6A 3'UTR       27773535 chr1:186281822-186281823(-) Y 3'UTR       26075521 chr1:186283011-186283012(-) m6A 3'UTR       24981863//27773535 chr1:186283027-186283028(-) m6A 3'UTR       24981863//27773535 chr1:186283090-186283091(-) m6A 3'UTR       24981863//28052920//27773535 chr1:186283121-186283122(-) m6A CDS       24981863//28052920//27773535 chr1:186283767-186283768(-) m6A CDS       24981863//26404942//27773535 chr1:186283797-186283798(-) m6A CDS       24981863//27773535 chr1:186283808-186283809(-) m6A CDS       24981863//27773535 chr1:186283815-186283816(-) m6A CDS       24981863//27773535 chr1:186287630-186287631(-) m6A CDS       27773535 chr1:186287694-186287695(-) m6A CDS//exon       27773535 chr1:186292829-186292830(-) m6A CDS       - chr1:186292862-186292863(-) m6A CDS       - chr1:186292919-186292920(-) m6A CDS       - chr1:186292946-186292947(-) m6A CDS       - chr1:186294667-186294668(-) m6A exon//intron       - chr1:186294900-186294901(-) m6A CDS//exon       24981863//28052920//27773535 chr1:186294955-186294956(-) m6A CDS//exon       24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr1:186294973-186294974(-) m6A CDS//exon       24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr1:186295282-186295283(-) m6A CDS//exon       24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:186296597-186296598(-) m6A CDS       24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:186296625-186296626(-) m1A CDS       26863196 chr1:186296746-186296747(-) m6A CDS       24981863//27773535 chr1:186296757-186296758(-) m6A CDS       24981863//26404942//27773535 chr1:186300670-186300671(-) m6A CDS       26404942//27773535 chr1:186301331-186301332(-) m6A CDS       26404942//27773535 chr1:186302500-186302501(-) m6A CDS       27773535 chr1:186303650-186303651(-) m6A CDS       24981863//27773535 chr1:186304227-186304228(-) m6A CDS       24981863//27773535 chr1:186304243-186304244(-) m6A CDS       24981863//27773535 chr1:186304252-186304253(-) m6A CDS       24981863//27773535 chr1:186304481-186304482(-) m6A CDS       24981863//27773535 chr1:186304511-186304512(-) m6A CDS       24981863//27773535 chr1:186304525-186304526(-) Gm CDS       - chr1:186304532-186304533(-) m6A CDS       24981863//27773535 chr1:186304634-186304635(-) m6A CDS       24981863//27773535//22575960 chr1:186305675-186305676(-) m6A CDS       24981863//27773535 chr1:186305726-186305727(-) m6A CDS       24981863//27773535 chr1:186305760-186305761(-) m6A CDS       24981863//27773535//27371828 chr1:186305784-186305785(-) m6A CDS       24981863//27773535//27371828 chr1:186305807-186305808(-) m6A CDS       24981863//27773535//27371828 chr1:186306188-186306189(-) m6A CDS       24981863//27773535//27371828 chr1:186306216-186306217(-) m6A CDS       24981863//27773535//27371828 chr1:186306256-186306257(-) m6A CDS       24981863//27773535 chr1:186306278-186306279(-) m6A CDS       24981863//27773535 chr1:186307185-186307186(-) m6A CDS       24981863//27773535 chr1:186307199-186307200(-) m6A CDS       24981863//27773535 chr1:186307238-186307239(-) m6A CDS       24981863//27773535 chr1:186307279-186307280(-) m6A CDS       24981863//27773535 chr1:186307292-186307293(-) m6A CDS       24981863//27773535 chr1:186307304-186307305(-) m6A CDS       24981863//27773535//22575960 chr1:186307345-186307346(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186308793-186308794(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186310282-186310283(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310410-186310411(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310416-186310417(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310448-186310449(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310469-186310470(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310475-186310476(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310488-186310489(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310508-186310509(-) m6A CDS//exon       24981863//27773535//27371828//22575960 chr1:186310571-186310572(-) m6A exon//intron       24981863//27773535//27371828 chr1:186310579-186310580(-) m6A exon//intron       24981863//27773535//27371828 chr1:186312496-186312497(-) m6A CDS//exon       24981863 chr1:186312520-186312521(-) m6A CDS//exon       24981863 chr1:186312573-186312574(-) m6A CDS//exon       24981863//22575960 chr1:186313057-186313058(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186313172-186313173(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186313177-186313178(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186313577-186313578(-) m6A CDS       24981863//27773535//22575960 chr1:186314809-186314810(-) m6A CDS       27773535 chr1:186315272-186315273(-) m6A CDS       24981863//27773535 chr1:186315311-186315312(-) m6A CDS       24981863//27773535 chr1:186315317-186315318(-) m6A CDS       24981863//27773535 chr1:186315358-186315359(-) m6A CDS       24981863//27773535//22575960 chr1:186316426-186316427(-) m6A CDS       24981863//27773535//22575960 chr1:186316436-186316437(-) m6A CDS       24981863//27773535//22575960 chr1:186316477-186316478(-) m6A CDS       24981863//28052920//27773535//22575960 chr1:186316497-186316498(-) m6A CDS       24981863//28052920//27773535//22575960 chr1:186316504-186316505(-) m6A CDS       24981863//28052920//27773535//22575960 chr1:186316540-186316541(-) m6A CDS       24981863//28052920//27773535//22575960 chr1:186319363-186319364(-) m6A CDS       24981863//28052920//26404942//27773535//22575960 chr1:186319415-186319416(-) m6A CDS       24981863//26404942//27773535 chr1:186319454-186319455(-) m6A CDS       24981863//26404942//27773535//22575960 chr1:186319480-186319481(-) m6A CDS       24981863//27773535//22575960 chr1:186319496-186319497(-) m6A CDS       24981863//27773535//22575960 chr1:186320491-186320492(-) m6A CDS       24981863//27773535//22575960 chr1:186320536-186320537(-) m6A CDS       24981863//27773535//22575960 chr1:186320542-186320543(-) m6A CDS       24981863//27773535//22575960 chr1:186320569-186320570(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186320574-186320575(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186320580-186320581(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186321115-186321116(-) m6A CDS//exon       27773535 chr1:186321138-186321139(-) m6A CDS//exon       27773535 chr1:186321152-186321153(-) m6A CDS//exon       27773535//27371828 chr1:186322882-186322883(-) m6A CDS//exon       26404942//27773535//27371828//22575960 chr1:186322909-186322910(-) m6A CDS//exon       26404942//27773535//27371828//22575960 chr1:186324606-186324607(-) m6A CDS//exon       24981863 chr1:186324615-186324616(-) m6A CDS//exon       24981863 chr1:186326541-186326542(-) m6A CDS//exon       24981863 chr1:186326548-186326549(-) m6A CDS//exon       24981863 chr1:186326565-186326566(-) m6A CDS//exon       24981863 chr1:186327759-186327760(-) m6A CDS//exon       22575960 chr1:186328942-186328943(-) m6A CDS//exon       24981863//22575960 chr1:186329072-186329073(-) m6A CDS//exon       22575960 chr1:186329080-186329081(-) m6A CDS//exon       22575960 chr1:186329106-186329107(-) m6A CDS//exon       22575960 chr1:186330775-186330776(-) m6A CDS//exon       24981863//27773535 chr1:186330784-186330785(-) m6A CDS//exon       24981863//27773535 chr1:186330805-186330806(-) m6A CDS//exon       24981863//27773535 chr1:186330938-186330939(-) m6A CDS//exon       24981863//26404942//27773535 chr1:186330992-186330993(-) m6A CDS//exon       24981863//26404942//27773535 chr1:186331464-186331465(-) m6A CDS//exon       24981863//27773535 chr1:186331475-186331476(-) m6A CDS//exon       24981863//27773535 chr1:186331494-186331495(-) m6A CDS//exon       24981863//27773535 chr1:186331503-186331504(-) m6A CDS//exon       24981863//27773535 chr1:186332043-186332044(-) m6A CDS//exon       24981863//27773535 chr1:186332051-186332052(-) m6A CDS//exon       24981863//27773535 chr1:186332057-186332058(-) m6A CDS//exon       24981863//27773535 chr1:186332500-186332501(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186332521-186332522(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186332551-186332552(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186337033-186337034(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186337045-186337046(-) m6A CDS//exon       24981863//27773535 chr1:186337056-186337057(-) m6A CDS//exon       24981863//27773535 chr1:186337067-186337068(-) m6A CDS//exon       24981863//27773535 chr1:186337098-186337099(-) m6A CDS//exon       24981863//27773535 chr1:186340137-186340138(-) m6A CDS//exon       24981863//27773535 chr1:186340144-186340145(-) m6A CDS//exon       24981863//27773535 chr1:186342494-186342495(-) m6A CDS//exon       24981863//27773535 chr1:186342532-186342533(-) m6A CDS//exon       24981863//27773535 chr1:186342545-186342546(-) m6A CDS//exon       24981863//27773535 chr1:186344021-186344022(-) Am CDS//exon       - chr1:186344092-186344093(-) m6A CDS//exon       27773535 chr1:186344116-186344117(-) m6A CDS//exon       27773535//27773536 chr1:186344331-186344332(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//27773536//22608085 chr1:186344763-186344764(-) m6A 5'UTR       25456834//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TPR	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: TPR

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.