Basic Information:

  VIRBase ID:  

VHID00374853

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9523

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          GPR137B:  NM_003272     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	GPR137B
miRBase Accession/Entrez ID	MIMAT0003717	7107
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TM7SF1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GPR137B	chr1:236334026(+) A-I      intronic chr1:236334021(+) A-I      intronic chr1:236334020(+) A-I      intronic chr1:236321605(+) A-I      intronic chr1:236320796(+) A-I      intronic chr1:236340973(+) A-I      intronic chr1:236340995(+) A-I      intronic chr1:236321604(+) A-I      intronic chr1:236341030(+) A-I      intronic chr1:236341091(+) A-I      intronic chr1:236321546(+) A-I      intronic chr1:236307552(+) A-I      intronic chr1:236308771(+) A-I      intronic chr1:236341095(+) A-I      intronic chr1:236341125(+) A-I      intronic chr1:236345927(+) A-I      intronic chr1:236345955(+) A-I      intronic chr1:236348111(+) A-I      intronic chr1:236321538(+) A-I      intronic chr1:236348147(+) A-I      intronic chr1:236328322(+) A-I      intronic chr1:236308839(+) A-I      intronic chr1:236315513(+) A-I      intronic chr1:236320722(+) A-I      intronic chr1:236334241(+) A-I      intronic chr1:236315914(+) A-I      intronic chr1:236315642(+) A-I      intronic chr1:236321681(+) A-I      intronic chr1:236348184(+) A-I      intronic chr1:236366471(+) A-I      intronic chr1:236314817(+) A-I      intronic chr1:236315612(+) A-I      intronic chr1:236314984(+) A-I      intronic chr1:236334051(+) A-I      intronic chr1:236315506(+) A-I      intronic chr1:236334089(+) A-I      intronic chr1:236328394(+) A-I      intronic chr1:236334212(+) A-I      intronic chr1:236334236(+) A-I      intronic chr1:236316102(+) A-I      intronic chr1:236315507(+) A-I      intronic chr1:236336487(+) A-I      intronic chr1:236336411(+) A-I      intronic chr1:236316003(+) A-I      intronic chr1:236309341(+) A-I      intronic chr1:236315803(+) A-I      intronic chr1:236315886(+) A-I      intronic chr1:236333206(+) A-I      intronic chr1:236321669(+) A-I      intronic chr1:236328274(+) A-I      intronic chr1:236336124(+) A-I      intronic chr1:236321563(+) A-I      intronic chr1:236321637(+) A-I      intronic chr1:236336227(+) A-I      intronic chr1:236321572(+) A-I      intronic chr1:236320784(+) A-I      intronic chr1:236336392(+) A-I      intronic chr1:236361608(+) A-I      intronic chr1:236333085(+) A-I      intronic chr1:236321684(+) A-I      intronic chr1:236336070(+) A-I      intronic chr1:236321699(+) A-I      intronic chr1:236320730(+) A-I      intronic chr1:236345950(+) A-I      intronic chr1:236336498(+) A-I      intronic chr1:236333229(+) A-I      intronic chr1:236341130(+) A-I      intronic chr1:236336519(+) A-I      intronic chr1:236345968(+) A-I      intronic chr1:236336062(+) A-I      intronic chr1:236320350(+) A-I      intronic chr1:236321560(+) A-I      intronic chr1:236307581(+) A-I      intronic chr1:236336266(+) A-I      intronic chr1:236315656(+) A-I      intronic chr1:236336244(+) A-I      intronic chr1:236336011(+) A-I      intronic chr1:236308931(+) A-I      intronic chr1:236315848(+) A-I      intronic chr1:236307594(+) A-I      intronic chr1:236336338(+) A-I      intronic chr1:236336391(+) A-I      intronic chr1:236336213(+) A-I      intronic chr1:236345273(+) A-I      intronic chr1:236336454(+) A-I      intronic chr1:236334117(+) A-I      intronic chr1:236316100(+) A-I      intronic chr1:236348341(+) A-I      intronic chr1:236307608(+) A-I      intronic chr1:236335260(+) A-I      intronic chr1:236336059(+) A-I      intronic chr1:236340956(+) A-I      intronic chr1:236334231(+) A-I      intronic chr1:236345960(+) A-I      intronic chr1:236315744(+) A-I      intronic chr1:236336407(+) A-I      intronic chr1:236315560(+) A-I      intronic chr1:236320734(+) A-I      intronic chr1:236336181(+) A-I      intronic chr1:236361609(+) A-I      intronic chr1:236334195(+) A-I      intronic chr1:236336422(+) A-I      intronic chr1:236336337(+) A-I      intronic chr1:236336201(+) A-I      intronic chr1:236315625(+) A-I      intronic chr1:236336175(+) A-I      intronic chr1:236336596(+) A-I      intronic chr1:236377573(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GPR137B	chr1:236307581(+) A-G intron -    22484847 chr1:236307594(+) A-G intron -    22484847 chr1:236307608(+) A-G intron -    22484847 chr1:236309341(+) A-G intron -    22484847 chr1:236315625(+) A-G intron -    22484847 chr1:236315656(+) A-G intron -    22484847 chr1:236315803(+) A-G intron -    22484847 chr1:236320730(+) A-G intron -    22484847 chr1:236320734(+) A-G intron -    22484847 chr1:236321560(+) A-G intron -    22484847 chr1:236321669(+) A-G intron -    22484847 chr1:236321684(+) A-G intron -    22484847 chr1:236336124(+) A-G intron -    22484847 chr1:236336244(+) A-G intron -    22484847 chr1:236336454(+) A-G intron -    22484847 chr1:236344106(+) T-C intron -    22484847 chr1:236345198(+) T-A intron -    22484847 chr1:236345199(+) T-A intron -    22484847 chr1:236345200(+) T-C intron -    22484847 chr1:236345201(+) T-C intron -    22484847 chr1:236361672(+) C-T intron -    22484847 chr1:236366628(+) C-T intron -    22484847

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GPR137B	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 ER-bound ribosome Cutaneous T-cell lymphoma cell lines (HuT78|SeAx)     19175411 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: GPR137B

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.