Basic Information:

  VIRBase ID:  

VHID00374727

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          PTPN7:  NR_037664     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	PTPN7
miRBase Accession/Entrez ID	MIMAT0003717	5778
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BPTP-4//HEPTP//LC-PTP//LPTP//PTPNI

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PTPN7	chr1:202118660(-) A-I      intronic chr1:202118681(-) A-I      intronic chr1:202118294(-) A-I      intronic chr1:202118659(-) A-I      intronic chr1:202118251(-) A-I      intronic chr1:202118264(-) A-I      intronic chr1:202118286(-) A-I      intronic chr1:202118727(-) A-I      intronic chr1:202118738(-) A-I      intronic chr1:202124966(-) A-I      intronic chr1:202118724(-) A-I      intronic chr1:202118680(-) A-I      intronic chr1:202118256(-) A-I      intronic chr1:202125181(-) A-I      intronic chr1:202118210(-) A-I      intronic chr1:202118255(-) A-I      intronic chr1:202118668(-) A-I      intronic chr1:202118250(-) A-I      intronic chr1:202125133(-) A-I      intronic chr1:202125129(-) A-I      intronic chr1:202126598(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PTPN7	chr1:202118000(-) C-A intron -    22484847 chr1:202118184(-) T-C intron -    22484847 chr1:202118210(-) A-G intron -    22484847 chr1:202118250(-) A-G intron -    22484847 chr1:202118256(-) A-G intron -    22484847 chr1:202118668(-) A-G intron -    22484847 chr1:202118680(-) A-G intron -    22484847 chr1:202118724(-) A-G intron -    22484847 chr1:202126598(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PTPN7	chr1:202116159-202116160(-) m6A 3'UTR       28052920//27371828 chr1:202116184-202116185(-) m6A 3'UTR       28052920//27371828 chr1:202116388-202116389(-) m6A 3'UTR       28052920//27371828 chr1:202116463-202116464(-) m6A 3'UTR       28052920//27371828 chr1:202116478-202116479(-) m6A 3'UTR       28052920//27371828 chr1:202116494-202116495(-) m6A 3'UTR       28052920//27371828 chr1:202116517-202116518(-) m6A 3'UTR       28052920//27371828 chr1:202116542-202116543(-) m6A 3'UTR       28052920//27371828 chr1:202116638-202116639(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202116680-202116681(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202116699-202116700(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202116768-202116769(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202116774-202116775(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202116792-202116793(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202116820-202116821(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202116876-202116877(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202117005-202117006(-) m6A 3'UTR       28052920//27371828 chr1:202117015-202117016(-) m6A 3'UTR       28052920//27371828 chr1:202117104-202117105(-) m6A 3'UTR       28052920//27371828 chr1:202117110-202117111(-) m6A 3'UTR       28052920//27371828 chr1:202117362-202117363(-) m6A 3'UTR       27371828 chr1:202117402-202117403(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202117440-202117441(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202117463-202117464(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202117471-202117472(-) m6A 3'UTR       28052920//26404942//27371828 chr1:202117490-202117491(-) m6A 3'UTR       28052920//27371828 chr1:202117502-202117503(-) m6A 3'UTR       28052920//27371828 chr1:202117569-202117570(-) m6A 3'UTR       27371828 chr1:202119056-202119057(-) m6A exon//intron       - chr1:202119068-202119069(-) m6A exon//intron       - chr1:202119152-202119153(-) m6A exon//intron       - chr1:202119176-202119177(-) m6A exon//intron       - chr1:202126878-202126879(-) m6A 5'UTR//CDS//exon//intron       - chr1:202126889-202126890(-) m6A 5'UTR//CDS//exon//intron       - chr1:202126913-202126914(-) m6A 5'UTR//CDS//exon//intron       - chr1:202126919-202126920(-) m6A 5'UTR//CDS//exon//intron       - chr1:202126937-202126938(-) m6A 5'UTR//CDS//exon//intron       - chr1:202127125-202127126(-) m6A exon//intron       - chr1:202127183-202127184(-) m6A exon//intron       - chr1:202127314-202127315(-) m6A CDS//exon//intron       - chr1:202127357-202127358(-) m6A CDS//exon//intron       27371828 chr1:202127374-202127375(-) m6A CDS//exon//intron       27371828 chr1:202127514-202127515(-) m6A exon//intron       27371828 chr1:202127533-202127534(-) m6A exon//intron       27371828 chr1:202128577-202128578(-) m6A 5'UTR//CDS//exon//intron       27371828 chr1:202128608-202128609(-) m6A CDS//intron       27371828 chr1:202128658-202128659(-) m6A 5'UTR//intron       27371828 chr1:202128669-202128670(-) m6A 5'UTR//intron       27371828 chr1:202128690-202128691(-) m6A 5'UTR//intron       27371828 chr1:202129075-202129076(-) m6A 5'UTR//intron       - chr1:202129095-202129096(-) m6A 5'UTR//intron       27371828 chr1:202129112-202129113(-) m6A 5'UTR//intron       27371828 chr1:202129711-202129712(-) m6A 5'UTR//CDS//exon//intron       27371828 chr1:202129719-202129720(-) m6A 5'UTR//CDS//exon//intron       27371828 chr1:202129731-202129732(-) m6A 5'UTR//CDS//exon//intron       27371828 chr1:202129976-202129977(-) m6A 5'UTR//intron       27371828 chr1:202129989-202129990(-) m6A 5'UTR//intron       27371828 chr1:202130055-202130056(-) m6A 5'UTR//intron       - chr1:202130419-202130420(-) m6A 5'UTR//intron       - chr1:202130437-202130438(-) m6A 5'UTR//intron       - chr1:202130527-202130528(-) m6A 5'UTR//CDS       - chr1:202130558-202130559(-) m6A 5'UTR//CDS       27371828 chr1:202130613-202130614(-) m6A 5'UTR//CDS       - chr1:202130683-202130684(-) m6A 5'UTR//CDS       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PTPN7	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: PTPN7

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.